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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ras homolog gene family, member J

TCL
This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: CAN, HAD, TCL1, IFN-gamma, ACID
Papers on TCL
Romidepsin in relapsed/refractory T-cell lymphomas: Italian experience and results of a named patient program.
New
Argnani et al., Bologna, Italy. In Leuk Lymphoma, Feb 2016
UNASSIGNED: Clinical trial results indicate that romidepsin, a histone deacetylase inhibitor, is a promising treatment in relapsed/refractory T-cell lymphomas (TCL).
Comprehensive serum cytokine analysis identifies IL-1RA and soluble IL-2Rα as predictors of event-free survival in T-cell lymphoma.
New
Witzig et al., Rochester, United States. In Ann Oncol, Jan 2016
In the angioimmunoblastic subset, all seven cytokines except IP-10 and in the peripheral T-cell lymphoma (TCL)-not otherwise specified subset, only IP-10, sIL-2Rα, MIG, and IL-8 were statistically elevated compared with control.
Functional studies of miR-130a on the inhibitory pathways of apoptosis in patients with chronic myeloid leukemia.
New
Zhang et al., Beijing, China. In Cancer Gene Ther, Dec 2015
The p53 mutation in chronic myeloid leukemia (CML) led to decreased overall survival and therapy resistance which was also closely correlated with the downstream proto-oncogenes BCL-2, TCL-1 and MCL-1.
Triclosan and bisphenol a affect decidualization of human endometrial stromal cells.
New
Crispi et al., Italy. In Mol Cell Endocrinol, Dec 2015
In this work, we studied the effects of triclosan (TCL) and bisphenol A (BPA), two widespread EDCs, on human endometrial stromal cells (ESCs), derived from endometrial biopsies from woman not affected by endometriosis.
Dual-Loop Bi-Atrial Macroreentrant Atrial Tachycardia in a Patient with Modified Cox Maze IV: Where is the Initial Ablation Target?
New
Momomura et al., Saitama, Japan. In J Cardiovasc Electrophysiol, Dec 2015
At the beginning of the procedure, the baseline tachycardia cycle length (TCL) was 300 ms.
Intrathecal CD4(+) and CD8(+) T cell responses to endogenously synthesized candidate disease-associated human autoantigens in multiple sclerosis patients.
New
Hintzen et al., Rotterdam, Netherlands. In Eur J Immunol, Nov 2015
Whereas all CSF-TCL responded strongly to mitogenic stimulation, no substantial T cell reactivity to cMSAg was observed.
[Expressions of Maspin and Ki67 in extranodal nasal type NK/T-cell lymphoma and the significance].
New
Gu et al., In Lin Chuang Er Bi Yan Hou Ke Za Zhi, Jul 2015
OBJECTIVE: To analyze the expression of Maspin and Ki67 in EN-NK/TCL and the significance.
TREC Based Newborn Screening for Severe Combined Immunodeficiency Disease: A Systematic Review.
Review
New
van Montfrans et al., Utrecht, Netherlands. In J Clin Immunol, May 2015
We extracted TREC content and cut-off values, number of retests, repeat DBS and referrals, and type and number of typical SCID and other T cell lymphopenia (TCL) cases.
Cladribine Analogues via O⁶-(Benzotriazolyl) Derivatives of Guanine Nucleosides.
Lakshman et al., New York City, United States. In Molecules, 2014
Against hairy cell leukemia (HCL), T-cell lymphoma (TCL) and chronic lymphocytic leukemia (CLL), cladribine was the most active against all.
Keratin and S100 calcium-binding proteins are major constituents of the bovine teat canal lining.
Wheeler et al., Hamilton, New Zealand. In Vet Res, 2014
The bovine teat canal provides the first-line of defence against pathogenic bacteria infecting the mammary gland, yet the protein composition and host-defence functionality of the teat canal lining (TCL) are not well characterised.
The role of miR-29 family members in malignant hematopoiesis.
Review
Modriansky et al., Olomouc, Czech Republic. In Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2014
In our view regulation of Tcl-1, Mcl-1 and DNA methyltransferases is relevant in case of hematological malignancies, hence these are the focus of this review.
Cladribine Analogues via O⁶-(Benzotriazolyl) Derivatives of Guanine Nucleosides.
Lakshman et al., New York City, United States. In Molecules, 2014
Against hairy cell leukemia (HCL), T-cell lymphoma (TCL) and chronic lymphocytic leukemia (CLL), cladribine was the most active against all.
Cutaneous peripheral T-cell lymphomas, unspecified/NOS and rare subtypes: a heterogeneous group of challenging cutaneous lymphomas.
Review
Dummer et al., Zürich, Switzerland. In G Ital Dermatol Venereol, 2012
In the WHO-EORTC classification as well as the WHO classification, three entities have been delineated as provisional rare subtypes of PTL based on their characteristic clinico-pathological, immunophenotypic and prognostic features and have been separated out from PTL, NOS: Primary cutaneous CD4-positive small/medium T-cell lymphoma (CD4+ SMTL), primary cutaneous CD8-positive aggressive epidermotropic T-cell lymphoma (CD8+ AECTCL), and primary cutaneous gamma/delta T-cell lymphoma (CGD-TCL).
RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG.
GeneRIF
Oettgen et al., Boston, United States. In Blood, 2011
Our study supports a novel role for the Rho family member RhoJ in ednothelial cell morphogenesis and in particular in lumen formation
RhoJ/TCL regulates endothelial motility and tube formation and modulates actomyosin contractility and focal adhesion numbers.
GeneRIF
Heath et al., Birmingham, United Kingdom. In Arterioscler Thromb Vasc Biol, 2011
RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers.
Two atypical cases of cutaneous gamma/delta T-cell lymphomas.
Review
Bagot et al., Paris, France. In Dermatology, 2010
Cutaneous γ/δ T-cell lymphoma (CGD-TCL) is a recent entity described in the newly revised World Health Organization-European Organization for Research and Treatment of Cancer classification of cutaneous lymphomas, and is characterized by the γ/δ T-cell receptor expression on atypical lymphocytes.
TC10-like/TC10betaLong regulates adipogenesis by controlling mitotic clonal expansion.
GeneRIF
Imagawa et al., Nagoya, Japan. In Biol Pharm Bull, 2009
The results strongly suggest that TCL/TC10betaL regulates adipocyte differentiation by controlling mitotic clonal expansion and this regulatory effect is closely linked to C/EBPbeta and C/EBPdelta expression.
Thermally cross-linked superparamagnetic iron oxide nanoparticle-A10 RNA aptamer-doxorubicin conjugate
Review
Zhang, Bethesda, United States. In Unknown Journal, 2008
This coating becomes highly stabilized by simple heat treatment through condensation of hydrolyzed silane group (Si(OH)3) to form a thermally cross-linked (TCL) polymer.
The GTP/GDP cycling of rho GTPase TCL is an essential regulator of the early endocytic pathway.
GeneRIF
Blangy et al., Montpellier, France. In Mol Biol Cell, 2003
TCL is essential for clathrin-dependent endocytosed receptors to enter the early/sorting endosomes
Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation.
GeneRIF
Falasca et al., London, United Kingdom. In Embo J, 2003
Insulin induces phosphatidylinositol 3-phosphate formation through TC10 activation.
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