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Transcription factor 7-like 2

TCF4, TCF7L2, transcription factor 7-like 2
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: TCF, Insulin, HAD, CAN, AGE
Papers using TCF4 antibodies
Hepatocellular carcinoma.
Guan Xin-yuan, In PLoS ONE, 2005
... Primary antibodies to KLF-8, Axin1, p300, and TCF4 were purchased from Abcam.
Papers on TCF4
Norcantharidin blocks Wnt/β-catenin signaling via promoter demethylation of WIF-1 in glioma.
Yang et al., Hangzhou, China. In Oncol Rep, Feb 2016
Additionally, more investigation revealed that NCTD suppressed activity of Wnt/β-catenin signaling and transcription of β-catenin/TCF-4.
Muc1 enhances the beta-catenin protective pathway during ischemia-reperfusion injury.
Hughey et al., Somalia. In Am J Physiol Renal Physiol, Feb 2016
We also found downstream induction of β-catenin pro-survival factors (activated Akt, survivin, transcription factor TCF4 and its downstream target cyclin D1) and repression of pro-apoptotic factors (p53, active Bax and cleaved caspase 3) in control mouse kidneys that were absent or aberrant in kidneys of Muc1 KO mice.
Identification of novel genetic causes of Rett syndrome-like phenotypes.
Maciel et al., Guimarães, Portugal. In J Med Genet, Feb 2016
deletion encompassing four exons of the TCF4 gene and a mosaic UPD of chromosome 3. Variants in genes previously implicated in neurodevelopmental disorders (NDD) were identified in six patients (32%): de novo variants in EEF1A2, STXBP1 and ZNF238 were found in three patients, maternally inherited X linked variants in SLC35A2, ZFX and SHROOM4 were detected in two male patients and one homozygous variant in EIF2B2 was detected in one patient.
Genome-Wide Association Analysis of Young Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.
Mitchell et al., Göteborg, Sweden. In Stroke, Feb 2016
The associated locus is in an intergenic region between TCF7L2 and HABP2.
A HuGE Review and Meta-Analyses of Genetic Associations in New Onset Diabetes after Kidney Transplantation.
McKnight et al., Belfast, United Kingdom. In Plos One, Dec 2015
(n = 1,270 individuals), and TCF7L2 rs7903146 p = 0.01 OR = 1.41, 95% CI = 1.07-1.85
The association between the rs11196218A/G polymorphism of the TCF7L2 gene and type 2 diabetes in the Chinese Han population: a meta-analysis.
Wei et al., Tianjin, China. In Clinics (sao Paulo), Aug 2015
Transcription factor 7-like 2 has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups in recent years.
The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis.
Mani et al., Beijing, China. In J Diabetes Res, 2014
BACKGROUND: The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive.
Fuchs Corneal Dystrophy.
Gottsch et al., Baltimore, United States. In Prog Mol Biol Transl Sci, 2014
A trinucleotide repeat in TCF4 correlates strongly with disease status and interacts in common pathways with previously identified genes.
The Utility of Next-Generation Sequencing in Gene Discovery for Mutation-Negative Patients with Rett Syndrome.
Christodoulou et al., Sydney, Australia. In Front Cell Neurosci, 2014
Over 90% of patients with classical RTT have mutations in the X-linked methyl-CpG-binding (MECP2) gene, while other genes, including cyclin-dependent kinase-like 5 (CDKL5), Forkhead box protein G1 (FOXG1), myocyte-specific enhancer factor 2C (MEF2C), and transcription factor 4 (TCF4), have been associated with phenotypes overlapping with RTT.
Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.
Amoli et al., Tehrān, Iran. In J Diabetes Res, 2014
We found significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM, HNFα and MODY, haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ERα, PPAR-γ2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, INSR, ACE, apoA-I, apo E, adiponectin, PTPN1, CETP, AT1R, resistin, MMP-3, BChE K, AT2R, SUMO4, IL-10, VEGF, MTHFR, and GSTM1 with T2DM or its complications.
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression.
Batlle et al., Barcelona, Spain. In Nat Cell Biol, 2014
In human tumours, GATA6 competes with β-catenin/TCF4 for binding to a distal regulatory region of the BMP4 locus that has been linked to increased susceptibility to development of CRC.
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Zheng et al., Nashville, United States. In Nat Genet, 2014
Two of these loci map to genes (TCF7L2 and TGFB1) with established roles in colorectal tumorigenesis.
MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells.
Yang et al., In Nat Cell Biol, 2014
Mechanistically, Snail induces the expression of microRNA-146a (miR-146a) through the β-catenin-TCF4 complex.
In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators.
Fuchs et al., New York City, United States. In Nat Cell Biol, 2014
We show that during HFSC quiescence, TCF3, TCF4 and TLE (Groucho) bind coordinately and transcriptionally repress Wnt target genes.
LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans.
Mani et al., New Haven, United States. In Cell Metab, 2013
Further investigations showed that the LRP6(R611C) mutation diminishes TCF7L2-dependent transcription of the IR while it increases the stability of IGFR and enhances mTORC1 activity.
KLF4 and SOX9 transcription factors antagonize β-catenin and inhibit TCF-activity in cancer cells.
Lincoln et al., Mobile, United States. In Biochim Biophys Acta, 2012
Both Sox9 and KLF4 interact with beta-catenin in an immunoprecipitation assay and reduce its binding to TCF4.
Identification of novel T cell factor 4 (TCF-4) binding sites on the HIV long terminal repeat which associate with TCF-4, β-catenin, and SMAR1 to repress HIV transcription.
Al-Harthi et al., Chicago, United States. In J Virol, 2012
TCF-4, beta-catenin, and SMAR1 tether at the -143-nucleotide site on the HIV LTR to inhibit HIV promoter activity.
Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling.
Zhang et al., Beijing, China. In Embo Rep, 2012
Kindlin 2 forms a tripartite complex with beta-catenin and TCF4.
TCF7L2 polymorphism and cognitive test performance in cardiovascular disease.
Cohen et al., Kent, United States. In Psychogeriatrics, 2012
Older cardiovascular disease patients with the TCF7L2 TT genotype performed worse on tests of attention/executive/ psychomotor speed than CC and CT genotype carriers.
Reduction in Tcf7l2 expression decreases diabetic susceptibility in mice.
Shu et al., Baltimore, United States. In Int J Biol Sci, 2011
The results suggest that decreased expression of Tcf7l2 confers reduction of diabetic susceptibility in mice via regulation on the metabolism of glucose and lipid.
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