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Hepatocyte nuclear factor 4, alpha

TCF, HNF4alpha, HNF-4, MODY, hepatocyte nuclear factor 4alpha
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, TCF4, V1a, HAD, c-Myc
Papers using TCF antibodies
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
Supplier
Wang Cun-Yu et al., In The Journal of Cell Biology, 1997
... For stable transfection, Rat-1/Wnt-1 cells were cotransfected with pcDNA3-flag-DN-Tcf-4, encoding the dominant-negative mutant (DN) of Tcf-4, or control empty vector and pBabe vector, containing a puromycin selectable marker, with Superfect (QIAGEN), according to the manufacturer's ...
Papers on TCF
Mutation of β-catenin in a radiation and estrogen breast cancer model.
New
Calaf et al., New York City, United States. In Int J Oncol, 22 Nov 2014
However, β-catenin/TCF-4 complex was found only in Alpha5 and Tumor2.
TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations.
New
Sanson et al., Paris, France. In Br J Cancer, 14 Nov 2014
TERTp-mut creates a binding site for Ets/TCF transcription factors, whereas the common rs2853669 polymorphism disrupts another Ets/TCF site on TERT promoter.Methods:We sequenced for TERTp-mut in 807 glioma DNAs and in 235 blood DNAs and analysed TERT expression by RT-PCR in 151 samples.
Phenotypic heterogeneity in monogenic diabetes: The clinical and diagnostic utility of a gene panel-based next-generation sequencing approach.
New
Del Gaudio et al., Chicago, United States. In Mol Genet Metab, 28 Oct 2014
We thus developed a targeted next-generation sequencing (NGS) assay for the detection of mutations in 36 genes known to cause monogenic forms of diabetes, including transient or permanent neonatal diabetes mellitus (TNDM or PNDM), maturity-onset diabetes of the young (MODY) and rare syndromic forms of diabetes.
TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells.
New
Impact
Xue et al., Iowa City, United States. In Nat Immunol, Jul 2014
The transcription factors TCF-1 and LEF-1 are essential for early T cell development, but their roles beyond the CD4(+)CD8(+) double-positive (DP) stage are unknown.
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
New
Impact
Powell et al., Baltimore, United States. In Nat Immunol, May 2014
Simultaneously, SGK1 repressed the production of interferon-γ (IFN-γ) by controlling expression of the long isoform of the transcription factor TCF-1.
CCM1 and the second life of proteins in adhesion complexes.
Review
New
Burgering et al., Utrecht, Netherlands. In Cell Adh Migr, May 2014
In this respect, β-catenin is a well-known example of an adhesion protein present both in cadherin complexes and in the nucleus where it regulates the TCF transcription factor.
Oncogenic mechanisms in Burkitt lymphoma.
Review
New
Staudt et al., Bethesda, United States. In Cold Spring Harb Perspect Med, Feb 2014
The transcription factor TCF-3 is central to Burkitt lymphoma pathogenesis.
Plakophilins in desmosomal adhesion and signaling.
Review
New
Keil et al., Halle, Germany. In Cell Commun Adhes, Feb 2014
β-catenin (armadillo in Drosophila) is the prototype of a multifunctional molecule that regulates cell adhesion via adherens junctions and cell signaling via LEF/TCF transcription factors.
Role and regulation of β-catenin signaling during physiological liver growth.
Review
New
Monga, Pittsburgh, United States. In Gene Expr, Dec 2013
Such activation of this progrowth protein is observed as nuclear translocation of β-catenin and formation of its complex with the T-cell factor (TCF) family of transcription factors.
Systematic analysis of blood cell transcriptome in end-stage chronic respiratory diseases.
New
COLT Consortium et al., Nantes, France. In Plos One, Dec 2013
With the common signature, we validated T-Cell Factor 7 (TCF-7) and Interleukin 7 Receptor (IL-7R), two genes related to T lymphocyte activation, as being under-expressed.
MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/β-catenin signaling.
New
Kim et al., Seoul, South Korea. In Cell Death Dis, Dec 2013
Inactivation of glycogen synthase kinase (GSK)-3β leads to β-catenin accumulation in the nucleus, where it couples with T-cell factor (TCF), an association that is disrupted by ICAT (inhibitor of β-catenin and T cell factor).
Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes.
New
Impact
Altshuler et al., Cambridge, United States. In Nat Genet, Nov 2013
We sequenced seven genes for maturity-onset diabetes of the young (MODY) in well-phenotyped population samples (n = 4,003).
Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells.
New
Impact
Grosschedl et al., Freiburg, Germany. In Nat Immunol, Aug 2013
In particular, genes encoding the transcription factors Id2 and TCF-1 were bound and repressed by EBF1.
T cell factor 1 is required for group 2 innate lymphoid cell generation.
New
Impact
Bhandoola et al., Philadelphia, United States. In Immunity, May 2013
Here we report that ILC2 development required T cell factor 1 (TCF-1, the product of the Tcf7 gene), a transcription factor also implicated in T cell lineage specification.
Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4α in vitro and in vivo.
GeneRIF
Cao et al., Wuhan, China. In J Biol Chem, 2012
Mucroporin-M1 peptide can activate the MAPK pathway and then reduce the expression of HNF4alpha, resulting in the inhibition of HBV replication in vitro and in vivo.
Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors.
GeneRIF
Sladek et al., Riverside, United States. In Nucleic Acids Res, 2012
HNF4-specific DNA recognition and transactivation are mediated by residues Asp69 and Arg76 in the DNA-binding domain.
The transcription factor HNF-4α: a key factor of the intestinal uptake of fatty acids in mouse.
GeneRIF
Lacorte et al., Paris, France. In Am J Physiol Gastrointest Liver Physiol, 2012
We conclude that the transcription factor HNF-4alpha is a key factor of the intestinal absorption of dietary lipids, which controls this process as early as in the initial step of fatty acid uptake by enterocytes.
Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the young.
GeneRIF
Owen et al., Oxford, United Kingdom. In Diabetes Care, 2012
In the type 1 diabetic group, two HNF1A mutations were found (0.8% prevalence). In type 2 diabetic subjects, 10 HNF1A, two HNF4A, and one GCK mutation were identified
Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.
GeneRIF
van Vlijmen et al., Leiden, Netherlands. In Plos One, 2011
In the mouse, HNF4alpha has a direct and essential regulatory role for multiple hepatic coagulation genes, while a role for C/EBPalpha is more restricted.
Insulin gene mutations and diabetes.
Review
Nanjo et al., Wakayama, Japan. In J Diabetes Investig, 2011
Maturity-onset diabetes of the young (MODY) or an autoantibody-negative type 1-like phenotype has also been reported.
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