Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
In The Journal of Cell Biology, 1997
... For stable transfection, Rat-1/Wnt-1 cells were cotransfected with pcDNA3-flag-DN-Tcf-4, encoding the dominant-negative mutant (DN) of Tcf-4, or control empty vector and pBabe vector, containing a puromycin selectable marker, with Superfect (QIAGEN), according to the manufacturer's ...
Modulating and measuring wingless signalling.
London, United Kingdom. In Methods, 24 Apr 2014
Various reporters have been devised by placing TCF-binding sites or DNA fragments from known target genes upstream of luciferase-coding sequences.
Wnt signaling pathway in non-small cell lung cancer.
Ottawa, Canada. In J Natl Cancer Inst, Jan 2014
Overexpression of Wnt-1, -2, -3, and -5a and of Wnt-pathway components Frizzled-8, Dishevelled, Porcupine, and TCF-4 is common in resected NSCLC and is associated with poor prognosis.
TERT promoter mutations in cancer development.
Heidelberg, Germany. In Curr Opin Genet Dev, Jan 2014
The newly described germline and recurrent somatic mutations in melanoma and other cancers in the TERT promoter that create de novo E-twenty six/ternary complex factors (Ets/TCF) binding sites, provide an insight into the possible cause of tumor-specific increased TERT expression.
Collagen VI in cancer and its biological mechanisms.
Padova, Italy. In Trends Mol Med, Jul 2013
A growing number of studies indicate that collagen VI directly affects malignant cells by acting on the Akt-GSK-3β-β-catenin-TCF/LEF axis, enhancing the production of protumorigenic factors and inducing epithelial-mesenchymal transition.
Recent progresses in identifying nuclear receptors and their families.
Jingdezhen, China. In Curr Top Med Chem, 2012
According to their different action mechanisms or functions, NR superfamily has been classified into seven families: NR1 (thyroid hormone like), NR2 (HNF4-like), NR3 (estrogen like), NR4 (nerve growth factor IB-like), NR5 (fushi tarazu-F1 like), NR6 (germ cell nuclear factor like), and NR0 (knirps or DAX like).