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Hepatocyte nuclear factor 4, alpha

TCF, HNF4alpha, HNF-4, MODY, hepatocyte nuclear factor 4alpha
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, TCF4, HAD, c-Myc
Papers using TCF antibodies
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
Supplier
Wang Cun-Yu et al., In The Journal of Cell Biology, 1997
... For stable transfection, Rat-1/Wnt-1 cells were cotransfected with pcDNA3-flag-DN-Tcf-4, encoding the dominant-negative mutant (DN) of Tcf-4, or control empty vector and pBabe vector, containing a puromycin selectable marker, with Superfect (QIAGEN), according to the manufacturer's ...
Papers on TCF
Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.
New
Krappmann et al., München, Germany. In Oncogene, Feb 2016
Increased β-catenin amounts alone were not sufficient to induce classical WNT target gene signatures, but could augment TCF/LEF-dependent transcriptional activation in response to WNT signaling.
Norcantharidin blocks Wnt/β-catenin signaling via promoter demethylation of WIF-1 in glioma.
New
Yang et al., Hangzhou, China. In Oncol Rep, Feb 2016
Additionally, more investigation revealed that NCTD suppressed activity of Wnt/β-catenin signaling and transcription of β-catenin/TCF-4.
The tumor suppressive role of RASSF1A in osteosarcoma through the Wnt signaling pathway.
New
Zang et al., Changsha, China. In Tumour Biol, Feb 2016
Wnt/β-catenin activity was measured by TCF reporter dual-luciferase assay.
Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling.
New
Wang et al., Xiamen, China. In Biosci Rep, Feb 2016
Further examination demonstrated that SNX27 inhibits the Wnt regulated transcription activity of TCF/LEF.
Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity.
New
Impact
Pasini et al., Milano, Italy. In Cell Stem Cell, Feb 2016
By dissecting the PRC1-dependent transcription program in intestinal stem cells, we demonstrate that PRC1 represses a large number of non-lineage-specific transcription factors that directly affect β-catenin/Tcf transcriptional activity.
A family with the Arg103Pro mutation in the NEUROD1 gene detected by Next-Generation Sequencing - clinical characteristics of mutation carriers.
New
Malecki et al., Kraków, Poland. In Eur J Med Genet, Feb 2016
Interestingly, one mutation carrier had a history of transient neonatal hypoglycemia, of which the clinical course resembled episodes typical for HNF4A-MODY.
TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.
New
Impact
Bhandoola et al., Bethesda, United States. In Nat Immunol, Oct 2015
We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors.
LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
New
Impact
Crotty et al., Los Angeles, United States. In Nat Immunol, Sep 2015
Here we report that selective loss of Lef1 or Tcf7 (which encode the transcription factor LEF-1 or TCF-1, respectively) resulted in T(FH) cell defects, while deletion of both Lef1 and Tcf7 severely impaired the differentiation of T(FH) cells and the formation of GCs.
The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection.
New
Impact
Wu et al., Chongqing, China. In Nat Immunol, Sep 2015
Here we found that the transcription factor TCF-1 was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection.
Recognition and Management of Individuals With Hyperglycemia Because of a Heterozygous Glucokinase Mutation.
Review
New
Hattersley et al., Exeter, United Kingdom. In Diabetes Care, Jul 2015
Glucokinase-maturity-onset diabetes of the young (GCK-MODY), also known as MODY2, is caused by heterozygous inactivating mutations in the GCK gene.
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.
New
Impact
Clevers et al., Utrecht, Netherlands. In Cell Stem Cell, Mar 2015
In turn, Ascl2, together with β-catenin/Tcf, activates the genes fundamental to the stem cell state.
Polyphenol Compound as a Transcription Factor Inhibitor.
Review
Park, Seoul, South Korea. In Nutrients, 2014
In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and β-catenin/T cell factor (Tcf)).
Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells.
Review
Zhu et al., Bethesda, United States. In Mediators Inflamm, 2014
Regulators such as Id2, GATA-3, Nfil3, TOX, and TCF-1 are expressed and function at various stages of ILC development.
The role of human cervical cancer oncogene in cancer progression.
Review
Wang et al., Jinan, China. In Int J Clin Exp Med, 2014
The HCCR manifests as a negative regulator of the p53 tumor suppressor gene, and its expression is regulated by the PI3K/Akt signaling pathway, modulated by TCF/β-catenin, it also participates in induction of the c-kit proto-oncogene, in activation of PKC and telomerase activities, but the accurate biochemical mechanisms of how HCCR contributes to the malignancies is still unknown.
The twisted survivin connection to angiogenesis.
Review
Quest et al., Santiago, Chile. In Mol Cancer, 2014
Mechanistically, we propose the existence of a positive feed-back loop involving PI3-kinase/Akt activation and enhanced β-Catenin-TCF/LEF-dependent VEGF expression followed by secretion.
Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4α in vitro and in vivo.
GeneRIF
Cao et al., Wuhan, China. In J Biol Chem, 2012
Mucroporin-M1 peptide can activate the MAPK pathway and then reduce the expression of HNF4alpha, resulting in the inhibition of HBV replication in vitro and in vivo.
Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors.
GeneRIF
Sladek et al., Riverside, United States. In Nucleic Acids Res, 2012
HNF4-specific DNA recognition and transactivation are mediated by residues Asp69 and Arg76 in the DNA-binding domain.
The transcription factor HNF-4α: a key factor of the intestinal uptake of fatty acids in mouse.
GeneRIF
Lacorte et al., Paris, France. In Am J Physiol Gastrointest Liver Physiol, 2012
We conclude that the transcription factor HNF-4alpha is a key factor of the intestinal absorption of dietary lipids, which controls this process as early as in the initial step of fatty acid uptake by enterocytes.
Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the young.
GeneRIF
Owen et al., Oxford, United Kingdom. In Diabetes Care, 2012
In the type 1 diabetic group, two HNF1A mutations were found (0.8% prevalence). In type 2 diabetic subjects, 10 HNF1A, two HNF4A, and one GCK mutation were identified
Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.
GeneRIF
van Vlijmen et al., Leiden, Netherlands. In Plos One, 2011
In the mouse, HNF4alpha has a direct and essential regulatory role for multiple hepatic coagulation genes, while a role for C/EBPalpha is more restricted.
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