Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
In The Journal of Cell Biology, 1997
... For stable transfection, Rat-1/Wnt-1 cells were cotransfected with pcDNA3-flag-DN-Tcf-4, encoding the dominant-negative mutant (DN) of Tcf-4, or control empty vector and pBabe vector, containing a puromycin selectable marker, with Superfect (QIAGEN), according to the manufacturer's ...
Targeting the β-catenin nuclear transport pathway in cancer.
Sydney, Australia. In Semin Cancer Biol, Aug 2014
In response to a wnt stimulus or specific gene mutations, β-catenin is stabilized and translocates to the nucleus where it binds TCF/LEF-1 transcription factors to transactivate genes that drive tumor formation.
Insulin gene mutations and diabetes.
Wakayama, Japan. In J Diabetes Investig, 2011
Maturity-onset diabetes of the young (MODY) or an autoantibody-negative type 1-like phenotype has also been reported.