Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
In The Journal of Cell Biology, 1997
... For stable transfection, Rat-1/Wnt-1 cells were cotransfected with pcDNA3-flag-DN-Tcf-4, encoding the dominant-negative mutant (DN) of Tcf-4, or control empty vector and pBabe vector, containing a puromycin selectable marker, with Superfect (QIAGEN), according to the manufacturer's ...
TERT promoter mutations in cancer development.
Heidelberg, Germany. In Curr Opin Genet Dev, Feb 2014
The newly described germline and recurrent somatic mutations in melanoma and other cancers in the TERT promoter that create de novo E-twenty six/ternary complex factors (Ets/TCF) binding sites, provide an insight into the possible cause of tumor-specific increased TERT expression.
Insulin gene mutations and diabetes.
Wakayama, Japan. In J Diabetes Investig, 2011
Maturity-onset diabetes of the young (MODY) or an autoantibody-negative type 1-like phenotype has also been reported.