Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
In The Journal of Cell Biology, 1997
... For stable transfection, Rat-1/Wnt-1 cells were cotransfected with pcDNA3-flag-DN-Tcf-4, encoding the dominant-negative mutant (DN) of Tcf-4, or control empty vector and pBabe vector, containing a puromycin selectable marker, with Superfect (QIAGEN), according to the manufacturer's ...
Group 2 innate lymphoid cells in health and disease.
New York City, United States. In Cold Spring Harb Perspect Biol, May 2015
ILC2s arise from common lymphoid progenitors in the bone marrow, are dependent on the transcription factors RORα, GATA3, and TCF-1, and produce the type 2 cytokines interleukin (IL)-4, IL-5, IL-9, and/or IL-13.
Altering cancer transcriptomes using epigenomic inhibitors.
Los Angeles, United States. In Epigenetics Chromatin, Dec 2014
The canonical WNT signaling pathway initiates when WNT ligands bind to receptors, causing the nuclear localization of the co-activator β-catenin (CTNNB1), which leads to an association of β-catenin with a member of the TCF transcription factor family at regulatory regions of WNT-responsive genes.