gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Oct 2015.

Hepatocyte nuclear factor 4, alpha

TCF, HNF4alpha, HNF-4, MODY, hepatocyte nuclear factor 4alpha
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, TCF4, HAD, c-Myc
Papers using TCF antibodies
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
Wang Cun-Yu et al., In The Journal of Cell Biology, 1997
... For stable transfection, Rat-1/Wnt-1 cells were cotransfected with pcDNA3-flag-DN-Tcf-4, encoding the dominant-negative mutant (DN) of Tcf-4, or control empty vector and pBabe vector, containing a puromycin selectable marker, with Superfect (QIAGEN), according to the manufacturer's ...
Papers on TCF
Simvastatin inhibits neural cell apoptosis and promotes locomotor recovery via activation of Wnt/β-catenin signaling pathway after spinal cord injury.
Mei et al., Jinzhou, China. In J Neurochem, 07 Nov 2015
In specific, simvastatin administration after SCI significantly upregulated the expression of low-density lipoprotein receptor-related protein-6 (LRP-6) phosphorylation and β-catenin protein, increased the mRNA expression of lymphoid enhancer factor-1 (LEF-1) and T-cell factor-1 (TCF-1), and suppressed the expression of β-catenin phosphorylation in the spinal cord neurons.
Estradiol promotes cells invasion by activating Beta-catenin Signaling Pathway in endometriosis.
Liu et al., Wuhan, China. In Reproduction, 02 Nov 2015
Moreover, co-immunoprecipitation (COIP) and dual immunofluorescence studies confirmed ESR1, β-catenin and lymphoid enhancer factor-1/T cell factor-3 (LEF-1/TCF-3) co-localization in the nucleus in HESCs after E2 treatment.
TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.
Bhandoola et al., Bethesda, United States. In Nat Immunol, 31 Oct 2015
We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors.
Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling.
Padmanabhan et al., Tampa, United States. In Oncotarget, 30 Oct 2015
This will subsequently diminish β-catenin intracellular signaling and repress TCF/LEF target gene expression.
The transcription factor TCF-1 initiates the differentiation of TFH cells during acute viral infection.
Wu et al., Chongqing, China. In Nat Immunol, 30 Sep 2015
Here we found that the transcription factor TCF-1 was essential for both the initiation of TFH differentiation and the effector function of differentiated TFH cells during acute viral infection.
LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
Crotty et al., Los Angeles, United States. In Nat Immunol, 30 Sep 2015
Here we report that selective loss of Lef1 or Tcf7 (which encode the transcription factor LEF-1 or TCF-1, respectively) resulted in TFH cell defects, while deletion of both Lef1 and Tcf7 severely impaired the differentiation of TFH cells and the formation of GCs.
Recognition and Management of Individuals With Hyperglycemia Because of a Heterozygous Glucokinase Mutation.
Hattersley et al., Exeter, United Kingdom. In Diabetes Care, Jul 2015
Glucokinase-maturity-onset diabetes of the young (GCK-MODY), also known as MODY2, is caused by heterozygous inactivating mutations in the GCK gene.
The Critical Role of Akt in Cardiovascular Function.
Su et al., Augusta, United States. In Vascul Pharmacol, Jun 2015
beta-catenin/Tcf-4, GLI1 and Stat-3 are some of few known transcriptional regulators of AKT gene.
Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells.
Kállay et al., Vienna, Austria. In J Steroid Biochem Mol Biol, Apr 2015
We hypothesized that 1,25-dihydroyvitamin D3 (1,25-D3), the active form of vitamin D3, promotes differentiation and reduces growth of LT97 cells by modulating β-catenin/T-cell factor (TCF) 4-mediated gene transcription.
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.
Clevers et al., Utrecht, Netherlands. In Cell Stem Cell, Mar 2015
In turn, Ascl2, together with β-catenin/Tcf, activates the genes fundamental to the stem cell state.
The role of human cervical cancer oncogene in cancer progression.
Wang et al., Jinan, China. In Int J Clin Exp Med, Dec 2014
The HCCR manifests as a negative regulator of the p53 tumor suppressor gene, and its expression is regulated by the PI3K/Akt signaling pathway, modulated by TCF/β-catenin, it also participates in induction of the c-kit proto-oncogene, in activation of PKC and telomerase activities, but the accurate biochemical mechanisms of how HCCR contributes to the malignancies is still unknown.
Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells.
Zhu et al., Bethesda, United States. In Mediators Inflamm, Dec 2014
Regulators such as Id2, GATA-3, Nfil3, TOX, and TCF-1 are expressed and function at various stages of ILC development.
Downhill Running-Based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway without Concomitant Decrease of Inflammatory Proteins.
R da Silva et al., Ribeirão Preto, Brazil. In Plos One, Dec 2014
Protein levels of peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) and hepatocyte nuclear factor 4alpha (HNF-4alpha) were higher in OTR versus CT.
Cooperative and independent functions of FGF and Wnt signaling during early inner ear development.
Shim et al., Milwaukee, United States. In Bmc Dev Biol, Dec 2014
We provide in vivo evidence that FGF signaling activates the Wnt signaling pathway upstream of TCF/Lef transcriptional activation.
TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells.
Xue et al., Iowa City, United States. In Nat Immunol, Jul 2014
The transcription factors TCF-1 and LEF-1 are essential for early T cell development, but their roles beyond the CD4(+)CD8(+) double-positive (DP) stage are unknown.
Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4α in vitro and in vivo.
Cao et al., Wuhan, China. In J Biol Chem, 2012
Mucroporin-M1 peptide can activate the MAPK pathway and then reduce the expression of HNF4alpha, resulting in the inhibition of HBV replication in vitro and in vivo.
Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors.
Sladek et al., Riverside, United States. In Nucleic Acids Res, 2012
HNF4-specific DNA recognition and transactivation are mediated by residues Asp69 and Arg76 in the DNA-binding domain.
The transcription factor HNF-4α: a key factor of the intestinal uptake of fatty acids in mouse.
Lacorte et al., Paris, France. In Am J Physiol Gastrointest Liver Physiol, 2012
We conclude that the transcription factor HNF-4alpha is a key factor of the intestinal absorption of dietary lipids, which controls this process as early as in the initial step of fatty acid uptake by enterocytes.
Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the young.
Owen et al., Oxford, United Kingdom. In Diabetes Care, 2012
In the type 1 diabetic group, two HNF1A mutations were found (0.8% prevalence). In type 2 diabetic subjects, 10 HNF1A, two HNF4A, and one GCK mutation were identified
Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.
van Vlijmen et al., Leiden, Netherlands. In Plos One, 2011
In the mouse, HNF4alpha has a direct and essential regulatory role for multiple hepatic coagulation genes, while a role for C/EBPalpha is more restricted.
share on facebooktweetadd +1mail to friends