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Hepatocyte nuclear factor 4, alpha

TCF, HNF4alpha, HNF-4, MODY, hepatocyte nuclear factor 4alpha
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, TCF4, V1a, HAD, c-Myc
Papers using TCF antibodies
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
Supplier
Wang Cun-Yu et al., In The Journal of Cell Biology, 1997
... For stable transfection, Rat-1/Wnt-1 cells were cotransfected with pcDNA3-flag-DN-Tcf-4, encoding the dominant-negative mutant (DN) of Tcf-4, or control empty vector and pBabe vector, containing a puromycin selectable marker, with Superfect (QIAGEN), according to the manufacturer's ...
Papers on TCF
Krüppel-like factor 5 incorporates into the β-catenin/TCF complex in response to LPA in colon cancer cells.
New
Chris Yun et al., Atlanta, United States. In Cell Signal, 12 Mar 2015
We found that LPA and Wnt3 additively activated the β-catenin/TCF (T cell factor) reporter activity in HCT116 cells.
The Tumor Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the Beta-catenin Coactivator BCL9-2 in Breast Cancer Cells.
New
Lallemand et al., Saint-Pierre-des-Corps, France. In Mol Cancer Res, 12 Mar 2015
Here, it is revealed that WWOX also interacts with the BCL9-2, a cofactor of the Wnt/beta-catenin pathway, to enhance the activity of the beta-catenin-TCF/LEF transcription factor complexes.
Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts.
New
Impact
Clevers et al., Utrecht, Netherlands. In Cell Stem Cell, 05 Mar 2015
In turn, Ascl2, together with β-catenin/Tcf, activates the genes fundamental to the stem cell state.
A Novel Mutation of the HNF1B Gene Associated With Hypoplastic Glomerulocystic Kidney Disease and Neonatal Renal Failure: A Case Report and Mutation Update.
New
Lemos et al., Lisbon, Portugal. In Medicine (baltimore), 28 Feb 2015
Affected individuals may present a variety of renal developmental abnormalities and/or maturity-onset diabetes of the young (MODY).A Portuguese 19-month-old male infant was evaluated due to hypoplastic glomerulocystic kidney disease and renal dysfunction diagnosed in the neonatal period that progressed to stage 5 chronic renal disease during the first year of life.
Identification and Functional Characterization of P159L Mutation in HNF1B in a Family with Maturity-Onset Diabetes of the Young 5 (MODY5).
New
Park et al., Seoul, South Korea. In Genomics Inform, Dec 2014
Mutation in HNF1B, the hepatocyte nuclear factor-1β (HNF-1β) gene, results in maturity-onset diabetes of the young (MODY) 5, which is characterized by gradual impairment of insulin secretion.
Ophthalmological phenotype associated with homozygous null mutation in the NEUROD1 gene.
New
Losonczy et al., Debrecen, Hungary. In Mol Vis, Dec 2014
Heterozygous loss-of-function mutations in NEUROD1 have previously been described as a cause of maturity-onset diabetes of the young (MODY) and late-onset diabetes.
Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer.
Review
New
Jiang et al., San Francisco, United States. In J Steroid Biochem Mol Biol, Dec 2014
Whereas, VDR binding to β-catenin may block its activation of TCF/LEF1 sites, β-catenin binding to VDR may enhance its activation of VDREs.
TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells.
New
Impact
Xue et al., Iowa City, United States. In Nat Immunol, Jul 2014
The transcription factors TCF-1 and LEF-1 are essential for early T cell development, but their roles beyond the CD4(+)CD8(+) double-positive (DP) stage are unknown.
Modulating and measuring Wingless signalling.
Review
New
Vincent, London, United Kingdom. In Methods, Jul 2014
Various reporters have been devised by placing TCF-binding sites or DNA fragments from known target genes upstream of luciferase-coding sequences.
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
New
Impact
Powell et al., Baltimore, United States. In Nat Immunol, May 2014
Simultaneously, SGK1 repressed the production of interferon-γ (IFN-γ) by controlling expression of the long isoform of the transcription factor TCF-1.
TERT promoter mutations in cancer development.
Review
New
Kumar et al., Heidelberg, Germany. In Curr Opin Genet Dev, Feb 2014
The newly described germline and recurrent somatic mutations in melanoma and other cancers in the TERT promoter that create de novo E-twenty six/ternary complex factors (Ets/TCF) binding sites, provide an insight into the possible cause of tumor-specific increased TERT expression.
Role and regulation of β-catenin signaling during physiological liver growth.
Review
Monga, Pittsburgh, United States. In Gene Expr, 2013
Such activation of this progrowth protein is observed as nuclear translocation of β-catenin and formation of its complex with the T-cell factor (TCF) family of transcription factors.
Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes.
Impact
Altshuler et al., Cambridge, United States. In Nat Genet, 2013
We sequenced seven genes for maturity-onset diabetes of the young (MODY) in well-phenotyped population samples (n = 4,003).
Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells.
Impact
Grosschedl et al., Freiburg, Germany. In Nat Immunol, 2013
In particular, genes encoding the transcription factors Id2 and TCF-1 were bound and repressed by EBF1.
Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4α in vitro and in vivo.
GeneRIF
Cao et al., Wuhan, China. In J Biol Chem, 2012
Mucroporin-M1 peptide can activate the MAPK pathway and then reduce the expression of HNF4alpha, resulting in the inhibition of HBV replication in vitro and in vivo.
Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors.
GeneRIF
Sladek et al., Riverside, United States. In Nucleic Acids Res, 2012
HNF4-specific DNA recognition and transactivation are mediated by residues Asp69 and Arg76 in the DNA-binding domain.
The transcription factor HNF-4α: a key factor of the intestinal uptake of fatty acids in mouse.
GeneRIF
Lacorte et al., Paris, France. In Am J Physiol Gastrointest Liver Physiol, 2012
We conclude that the transcription factor HNF-4alpha is a key factor of the intestinal absorption of dietary lipids, which controls this process as early as in the initial step of fatty acid uptake by enterocytes.
Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the young.
GeneRIF
Owen et al., Oxford, United Kingdom. In Diabetes Care, 2012
In the type 1 diabetic group, two HNF1A mutations were found (0.8% prevalence). In type 2 diabetic subjects, 10 HNF1A, two HNF4A, and one GCK mutation were identified
Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.
GeneRIF
van Vlijmen et al., Leiden, Netherlands. In Plos One, 2011
In the mouse, HNF4alpha has a direct and essential regulatory role for multiple hepatic coagulation genes, while a role for C/EBPalpha is more restricted.
Insulin gene mutations and diabetes.
Review
Nanjo et al., Wakayama, Japan. In J Diabetes Investig, 2011
Maturity-onset diabetes of the young (MODY) or an autoantibody-negative type 1-like phenotype has also been reported.
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