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Hepatocyte nuclear factor 4, alpha

TCF, HNF4alpha, HNF-4, MODY, hepatocyte nuclear factor 4alpha
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, TCF4, HAD, c-Myc
Papers using TCF antibodies
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
Supplier
Wang Cun-Yu et al., In The Journal of Cell Biology, 1997
... For stable transfection, Rat-1/Wnt-1 cells were cotransfected with pcDNA3-flag-DN-Tcf-4, encoding the dominant-negative mutant (DN) of Tcf-4, or control empty vector and pBabe vector, containing a puromycin selectable marker, with Superfect (QIAGEN), according to the manufacturer's ...
Papers on TCF
β-catenin is regulated by USP9x and mediates resistance to TRAIL-induced apoptosis in breast cancer.
New
Xie et al., Wuhan, China. In Oncol Rep, 29 Feb 2016
Luciferase reporter assays showed induction of DcR1/DcR2/OPG reporter activity observed upon co-transfection of β-catenin and Tcf-4.
Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.
New
Krappmann et al., München, Germany. In Oncogene, 18 Feb 2016
Increased β-catenin amounts alone were not sufficient to induce classical WNT target gene signatures, but could augment TCF/LEF-dependent transcriptional activation in response to WNT signaling.
Norcantharidin blocks Wnt/β-catenin signaling via promoter demethylation of WIF-1 in glioma.
New
Yang et al., Hangzhou, China. In Oncol Rep, 14 Feb 2016
Additionally, more investigation revealed that NCTD suppressed activity of Wnt/β-catenin signaling and transcription of β-catenin/TCF-4.
The tumor suppressive role of RASSF1A in osteosarcoma through the Wnt signaling pathway.
New
Zang et al., Changsha, China. In Tumour Biol, 11 Feb 2016
Wnt/β-catenin activity was measured by TCF reporter dual-luciferase assay.
A family with the Arg103Pro mutation in the NEUROD1 gene detected by Next-Generation Sequencing - clinical characteristics of mutation carriers.
New
Malecki et al., Kraków, Poland. In Eur J Med Genet, 07 Feb 2016
Interestingly, one mutation carrier had a history of transient neonatal hypoglycemia, of which the clinical course resembled episodes typical for HNF4A-MODY.
Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity.
New
Impact
Pasini et al., Milano, Italy. In Cell Stem Cell, 07 Feb 2016
By dissecting the PRC1-dependent transcription program in intestinal stem cells, we demonstrate that PRC1 represses a large number of non-lineage-specific transcription factors that directly affect β-catenin/Tcf transcriptional activity.
Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling.
New
Wang et al., Xiamen, China. In Biosci Rep, 07 Feb 2016
Further examination demonstrated that SNX27 inhibits the Wnt regulated transcription activity of TCF/LEF.
FOXC2 is up-regulated in pancreatic ductal adenocarcinoma and promotes the growth and migration of cancer cells.
New
Chen et al., Zhenjiang, China. In Tumour Biol, 06 Feb 2016
Moreover, FOXC2 was found to interact with beta-catenin and promote cell growth by activating beta-catenin/TCF signaling.
Comparison of the Expression of Hepatic Genes by Human Wharton's Jelly Mesenchymal Stem Cells Cultured in 2D and 3D Collagen Culture Systems.
New
Bahmanpour et al., Shīrāz, Iran. In Iran J Med Sci, 31 Jan 2016
The expression of the hepatic nuclear factor 4 (HNF4) was very low.
Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells.
New
Cheng et al., Wuhan, China. In Oncotarget, 31 Jan 2016
Ectopic expression of NICD with LV-Notch1 in LCSCs attenuated β-catenin/TCF dependent luciferase activity significantly.
Snail1 is required for the maintenance of the pancreatic acinar phenotype.
New
García de Herreros et al., Barcelona, Spain. In Oncotarget, 29 Jan 2016
Snail1 ablation in cultured PMCs downregulated the expression of several β-catenin/Tcf-4 target genes, modified the secretome of these cells and decreased their ability to maintain acinar markers in cultured pancreas cells.
TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.
New
Impact
Bhandoola et al., Bethesda, United States. In Nat Immunol, Oct 2015
We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors.
LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
New
Impact
Crotty et al., Los Angeles, United States. In Nat Immunol, Sep 2015
Here we report that selective loss of Lef1 or Tcf7 (which encode the transcription factor LEF-1 or TCF-1, respectively) resulted in T(FH) cell defects, while deletion of both Lef1 and Tcf7 severely impaired the differentiation of T(FH) cells and the formation of GCs.
The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection.
New
Impact
Wu et al., Chongqing, China. In Nat Immunol, Sep 2015
Here we found that the transcription factor TCF-1 was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection.
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.
New
Impact
Clevers et al., Utrecht, Netherlands. In Cell Stem Cell, Mar 2015
In turn, Ascl2, together with β-catenin/Tcf, activates the genes fundamental to the stem cell state.
Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4α in vitro and in vivo.
GeneRIF
Cao et al., Wuhan, China. In J Biol Chem, 2012
Mucroporin-M1 peptide can activate the MAPK pathway and then reduce the expression of HNF4alpha, resulting in the inhibition of HBV replication in vitro and in vivo.
Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors.
GeneRIF
Sladek et al., Riverside, United States. In Nucleic Acids Res, 2012
HNF4-specific DNA recognition and transactivation are mediated by residues Asp69 and Arg76 in the DNA-binding domain.
The transcription factor HNF-4α: a key factor of the intestinal uptake of fatty acids in mouse.
GeneRIF
Lacorte et al., Paris, France. In Am J Physiol Gastrointest Liver Physiol, 2012
We conclude that the transcription factor HNF-4alpha is a key factor of the intestinal absorption of dietary lipids, which controls this process as early as in the initial step of fatty acid uptake by enterocytes.
Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the young.
GeneRIF
Owen et al., Oxford, United Kingdom. In Diabetes Care, 2012
In the type 1 diabetic group, two HNF1A mutations were found (0.8% prevalence). In type 2 diabetic subjects, 10 HNF1A, two HNF4A, and one GCK mutation were identified
Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.
GeneRIF
van Vlijmen et al., Leiden, Netherlands. In Plos One, 2011
In the mouse, HNF4alpha has a direct and essential regulatory role for multiple hepatic coagulation genes, while a role for C/EBPalpha is more restricted.
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