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Hepatocyte nuclear factor 4, alpha

TCF, HNF4alpha, HNF-4, MODY, hepatocyte nuclear factor 4alpha
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, TCF4, HAD, c-Myc
Papers using TCF antibodies
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
Wang Cun-Yu et al., In The Journal of Cell Biology, 1997
... For stable transfection, Rat-1/Wnt-1 cells were cotransfected with pcDNA3-flag-DN-Tcf-4, encoding the dominant-negative mutant (DN) of Tcf-4, or control empty vector and pBabe vector, containing a puromycin selectable marker, with Superfect (QIAGEN), according to the manufacturer's ...
Papers on TCF
Human Cytomegalovirus modulates Expression of non-canonical Wnt receptor ROR2 to Alter Trophoblast Migration.
Rawlinson et al., Sydney, Australia. In J Virol, 11 Dec 2015
Mimicking the CMV-induced ROR2 protein expression via ectopic expression inhibited Wnt5a-induced trophoblast migration and reduced TCF/LEF-mediated transcription as measured using luciferase reporter assays.
Genetic testing for monogenic diabetes using targeted next-generation sequencing in the MODY cohort from Poland.
Małecki et al., In Pol Arch Med Wewn, 09 Dec 2015
Objectives We aimed to assess the feasibility of using NGS for detecting mutations in a set of known monogenic diabetes genes in a cohort of patients from Poland with earlier negative Sanger sequencing results for HNF1A-MODY or/and GCK-MODY.
Serum and glucocorticoid kinase 1 promoted the growth and migration of non-small cell lung cancer cells.
Zhengjian et al., Shanghai, China. In Gene, 06 Dec 2015
SGK1 promoted the phosphorylation of GSK3 beta and the accumulation of beta-catenin, up-regulation of the target genes downstream of beta-catenin/TCF signaling, and activating the transcriptional activity of beta-catenin/TCF complex.
Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity.
Pasini et al., Milano, Italy. In Cell Stem Cell, 28 Nov 2015
By dissecting the PRC1-dependent transcription program in intestinal stem cells, we demonstrate that PRC1 represses a large number of non-lineage-specific transcription factors that directly affect β-catenin/Tcf transcriptional activity.
TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow.
Bhandoola et al., Bethesda, United States. In Nat Immunol, 31 Oct 2015
We show that the transcription factor TCF-1 is required for the efficient generation of all known adult ILC subsets and their precursors.
LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
Crotty et al., Los Angeles, United States. In Nat Immunol, Sep 2015
Here we report that selective loss of Lef1 or Tcf7 (which encode the transcription factor LEF-1 or TCF-1, respectively) resulted in T(FH) cell defects, while deletion of both Lef1 and Tcf7 severely impaired the differentiation of T(FH) cells and the formation of GCs.
The transcription factor TCF-1 initiates the differentiation of T(FH) cells during acute viral infection.
Wu et al., Chongqing, China. In Nat Immunol, Sep 2015
Here we found that the transcription factor TCF-1 was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection.
Recognition and Management of Individuals With Hyperglycemia Because of a Heterozygous Glucokinase Mutation.
Hattersley et al., Exeter, United Kingdom. In Diabetes Care, Jul 2015
Glucokinase-maturity-onset diabetes of the young (GCK-MODY), also known as MODY2, is caused by heterozygous inactivating mutations in the GCK gene.
The Critical Role of Akt in Cardiovascular Function.
Su et al., Augusta, United States. In Vascul Pharmacol, Jun 2015
beta-catenin/Tcf-4, GLI1 and Stat-3 are some of few known transcriptional regulators of AKT gene.
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.
Clevers et al., Utrecht, Netherlands. In Cell Stem Cell, Mar 2015
In turn, Ascl2, together with β-catenin/Tcf, activates the genes fundamental to the stem cell state.
Wnt/β-catenin up-regulates Midkine expression in glioma cells.
Chen et al., Kaifeng, China. In Int J Clin Exp Med, Dec 2014
We further identified a TCF/LEF binding site, with which beta-catenin interacts, on the proximal promoter region of Midkine gene, by luciferase reporter and chromatin immunoprecipitation assays.
Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells.
Zhu et al., Bethesda, United States. In Mediators Inflamm, Dec 2014
Regulators such as Id2, GATA-3, Nfil3, TOX, and TCF-1 are expressed and function at various stages of ILC development.
The role of human cervical cancer oncogene in cancer progression.
Wang et al., Jinan, China. In Int J Clin Exp Med, Dec 2014
The HCCR manifests as a negative regulator of the p53 tumor suppressor gene, and its expression is regulated by the PI3K/Akt signaling pathway, modulated by TCF/β-catenin, it also participates in induction of the c-kit proto-oncogene, in activation of PKC and telomerase activities, but the accurate biochemical mechanisms of how HCCR contributes to the malignancies is still unknown.
Polyphenol Compound as a Transcription Factor Inhibitor.
Park, Seoul, South Korea. In Nutrients, Dec 2014
In this review, we focus on polyphenol compound inhibitors against dimeric forms of transcription factor components of intracellular signaling pathways (for instance, c-jun/c-fos (Activator Protein-1; AP-1), c-myc/max, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and β-catenin/T cell factor (Tcf)).
Retinoic Acid Ameliorates Pancreatic Fibrosis and Inhibits the Activation of Pancreatic Stellate Cells in Mice with Experimental Chronic Pancreatitis via Suppressing the Wnt/β-Catenin Signaling Pathway.
Wan et al., Shanghai, China. In Plos One, Dec 2014
Furthermore, RA induced significant PSC apoptosis, inhibited proliferation, suppressed TCF/LEF-dependent transcriptional activity and ECM production of PSC via down-regulation of TGFβRII, PDGFRβ and collagen 1α1 in vitro.
Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4α in vitro and in vivo.
Cao et al., Wuhan, China. In J Biol Chem, 2012
Mucroporin-M1 peptide can activate the MAPK pathway and then reduce the expression of HNF4alpha, resulting in the inhibition of HBV replication in vitro and in vivo.
Identification of a binding motif specific to HNF4 by comparative analysis of multiple nuclear receptors.
Sladek et al., Riverside, United States. In Nucleic Acids Res, 2012
HNF4-specific DNA recognition and transactivation are mediated by residues Asp69 and Arg76 in the DNA-binding domain.
The transcription factor HNF-4α: a key factor of the intestinal uptake of fatty acids in mouse.
Lacorte et al., Paris, France. In Am J Physiol Gastrointest Liver Physiol, 2012
We conclude that the transcription factor HNF-4alpha is a key factor of the intestinal absorption of dietary lipids, which controls this process as early as in the initial step of fatty acid uptake by enterocytes.
Systematic assessment of etiology in adults with a clinical diagnosis of young-onset type 2 diabetes is a successful strategy for identifying maturity-onset diabetes of the young.
Owen et al., Oxford, United Kingdom. In Diabetes Care, 2012
In the type 1 diabetic group, two HNF1A mutations were found (0.8% prevalence). In type 2 diabetic subjects, 10 HNF1A, two HNF4A, and one GCK mutation were identified
Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.
van Vlijmen et al., Leiden, Netherlands. In Plos One, 2011
In the mouse, HNF4alpha has a direct and essential regulatory role for multiple hepatic coagulation genes, while a role for C/EBPalpha is more restricted.
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