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Ras homolog gene family, member Q

TC10
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011] (from NCBI)
Papers on TC10
TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin.
GeneRIF
Philips et al., Montpellier, France. In J Cell Sci, 2009
These findings reveal a novel signaling pathway in human skeletal muscle that involves obscurin and the Rho GTPase TC10 and implicate this pathway in new sarcomere formation.
CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation.
GeneRIF
Mori et al., Maebashi, Japan. In J Biol Chem, 2009
CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation
Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5.
GeneRIF
Saltiel et al., Ann Arbor, United States. In Mol Biol Cell, 2008
the TC10/GAPEX-5/Rab5 axis mediates insulin-stimulated production of PI(3)P, which regulates trafficking of Glut4 vesicles
TC10alpha is required for insulin-stimulated glucose uptake in adipocytes.
GeneRIF
Saltiel et al., Ann Arbor, United States. In Endocrinology, 2007
TC10alpha is specifically required for insulin-stimulated glucose uptake in adipocytes
GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion.
GeneRIF
Matsuda et al., Ōsaka, Japan. In Dev Cell, 2006
We propose that an EGF-stimulated GAP accelerates GTP hydrolysis of TC10, thereby promoting vesicle fusion.
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