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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ras homolog gene family, member Q

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: Insulin, Rhodopsin, Cdc42, Akt, Actin
Papers on TC10
The effect of antithyroid drug use on delaying remission in high uptake Graves' disease following radioiodine ablation.
Seshadri et al., Chennai, India. In Endocr Connect, Feb 2016
Surprisingly, a directly proportional linear relationship(R2=0.92) was established between time to cure and radioiodine uptake(TC>30%=172days,TC10-30%=105days,p<0.001).Patients who used ATD medications took a proportionately longer duration to achieve remission (TCNO ATD=102days, TCATD=253days,p<0.001).
Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma.
Lu et al., Beijing, China. In Oncotarget, Jan 2016
IL-6, AP3B1, TC10, ONECUT2, IGF2BP1, MYO1D, and ANXA2 were confirmed to be miR-9 targets in HCC.
Down-regulation of microRNA-9 leads to activation of IL-6/Jak/STAT3 pathway through directly targeting IL-6 in HeLa cell.
Lu et al., Beijing, China. In Mol Carcinog, Apr 2015
Dual-luciferase reporting assay, real-time qPCR, and ELISA or Western blot confirmed four genes (CKAP2, HSPC159, IL-6, and TC10) to be novel direct target genes of miR-9.
The golgi-associated PDZ domain protein PIST/GOPC stabilizes the β1-adrenergic receptor in intracellular compartments after internalization.
Kreienkamp et al., Hamburg, Germany. In J Biol Chem, Apr 2015
The protein interacting specifically with Tc10 (PIST; also known as GOPC) is a trans-Golgi-associated protein that interacts through its single PDZ domain with a variety of cell surface receptors.
Modulation of glucose transporter protein by dietary flavonoids in type 2 diabetes mellitus.
Arya et al., Kuala Lumpur, Malaysia. In Int J Biol Sci, 2014
The antidiabetic potential of flavonoids are mainly through their modulatory effects on glucose transporter by enhancing GLUT-2 expression in pancreatic β cells and increasing expression and promoting translocation of GLUT-4 via PI3K/AKT, CAP/Cb1/TC10 and AMPK pathways.
The Rho GTPase Family Genes in Bivalvia Genomes: Sequence, Evolution and Expression Analysis.
Bao et al., Qingdao, China. In Plos One, 2014
RESULTS: In this study, we systematically identified and characterized a total set (Rho, Rac, Mig, Cdc42, Tc10, Rnd, RhoU, RhoBTB and Miro) of thirty Rho GTPase genes in three bivalve species, including nine in the Yesso scallop Patinopecten yessoensis, nine in the Zhikong scallop Chlamys farreri, and twelve in the Pacific oyster Crassostrea gigas.
Synaptic activity regulates AMPA receptor trafficking through different recycling pathways.
Green et al., Chicago, United States. In Elife, 2014
AMPAR recycling was blocked by alterations in the GTPase, TC10, which co-localized with Arf6 endosomes.
Global analyses of Chromosome 17 and 18 genes of lung telocytes compared with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes.
Wang et al., Shanghai, China. In Biol Direct, 2014
RESULTS: We compared gene expression profiles of murine pulmonary TCs on days 5 (TC5) and days 10 (TC10) with mesenchymal stem cells (MSCs), fibroblasts (Fbs), alveolar type II cells (ATII), airway basal cells (ABCs), proximal airway cells (PACs), CD8(+) T cells from bronchial lymph nodes (T-BL), and CD8(+) T cells from lungs (T-LL).
Rho GTPases in insulin-stimulated glucose uptake.
Satoh, Ōsaka, Japan. In Small Gtpases, 2013
In addition, the role for another Rho family member TC10 and its regulatory mechanism in adipocyte insulin signaling are described.
The role of small GTPases in neuronal morphogenesis and polarity.
Caceres et al., Santiago, Chile. In Cytoskeleton (hoboken), 2012
In this review we will comprehensively analyze findings that support the participation of RhoA, Rac, Cdc42, and TC10 in different neuronal morphogenetic events ranging from migration to synaptic plasticity.
Signalling to actin: role of C3G, a multitasking guanine-nucleotide-exchange factor.
Sasikumar et al., Hyderābād, India. In Biosci Rep, 2011
C3G is spatially and temporally regulated to act on Ras family GTPases Rap1, Rap2, R-Ras, TC21 and Rho family member TC10.
TC10 controls human myofibril organization and is activated by the sarcomeric RhoGEF obscurin.
Philips et al., Montpellier, France. In J Cell Sci, 2009
These findings reveal a novel signaling pathway in human skeletal muscle that involves obscurin and the Rho GTPase TC10 and implicate this pathway in new sarcomere formation.
CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation.
Mori et al., Maebashi, Japan. In J Biol Chem, 2009
CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation
Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5.
Saltiel et al., Ann Arbor, United States. In Mol Biol Cell, 2008
the TC10/GAPEX-5/Rab5 axis mediates insulin-stimulated production of PI(3)P, which regulates trafficking of Glut4 vesicles
TC10alpha is required for insulin-stimulated glucose uptake in adipocytes.
Saltiel et al., Ann Arbor, United States. In Endocrinology, 2007
TC10alpha is specifically required for insulin-stimulated glucose uptake in adipocytes
Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes.
Saltiel et al., Ann Arbor, United States. In Cell Metab, 2007
Using the TC10-interacting protein CIP4 as bait in a yeast two-hybrid screen, we cloned a RasGAP and VPS9 domain-containing protein, Gapex-5/RME-6.
Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking.
Ridley, London, United Kingdom. In Trends Cell Biol, 2006
However, recent research indicates that several other members of the Rho family, including Rif, RhoD, TC10 and Wrch1, and also related Rho-of-plants proteins (ROPs) in plants, stimulate actin polymerization and affect plasma membrane protrusion and/or vesicular traffic.
GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion.
Matsuda et al., Ōsaka, Japan. In Dev Cell, 2006
We propose that an EGF-stimulated GAP accelerates GTP hydrolysis of TC10, thereby promoting vesicle fusion.
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.
Saltiel et al., Ann Arbor, United States. In Nature, 2003
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin
Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10.
Saltiel et al., Ann Arbor, United States. In Nature, 2001
Here we show that phosphorylated Cbl recruits the CrkII-C3G complex to lipid rafts, where C3G specifically activates the small GTP-binding protein TC10.
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