GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Aug 2016.
T-box 3
Tbx3, UMS
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
HOS, Tbx2, HAD, CAN, p16
Papers using
Tbx3
antibodies
Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodeling
Supplier
In Cellular and Molecular Life Sciences, 2006
... Full-length (aa 1–723/743) and T-box region (aa 94–300/320) of Tbx3 or Tbx3 isoform2 (+exon 2a) were PCR amplified from human cDNA (NM_005996/NM_016569) and cloned into pMAL2C (Clontech) to generate MBP fusion ...
p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation
Supplier
In The Journal of Cell Biology, 2005
... anti-Rac1 mAb (Millipore), mouse anti-desmoplakin mAb (Progen), mouse anti-Trio pAb (Abnova), and mouse and rabbit anti-Tbx3 pAbs (Abcam) were purchased ...
Papers on
Tbx3
Novel copy number variants and major limb reduction malformation: Report of three cases.
New
Riyadh, Saudi Arabia. In Am J Med Genet A, Feb 2016
spanning 20 genes including TBX3 and TBX5, and a third patient with acheiropodia who had a nullizygous deletion of 102 kb on 7q36.3 spanning LMBR1.
Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses.
New
Impact
Uppsala, Sweden. In Nat Genet, Jan 2016
Here we show that pigment dilution in Dun horses is due to radially asymmetric deposition of pigment in the growing hair caused by localized expression of the T-box 3 (TBX3) transcription factor in hair follicles, which in turn determines the distribution of hair follicle melanocytes.
TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle.
New
Carbondale, United States. In Oncogene, Jan 2016
We have also found that the highly related T-box family member TBX3 does not repress PTEN in the muscle lineage.
A Dynamic Role of TBX3 in the Pluripotency Circuitry.
New
Ulm, Germany. In Stem Cell Reports, Jan 2016
TBX3 is the earliest expressed member of the T-box transcription factor family and is involved in maintenance and induction of pluripotency.
Population Variation Reveals Independent Selection toward Small Body Size in Chinese Debao Pony.
New
Beijing, China. In Genome Biol Evol, Dec 2015
More interestingly, we found a candidate gene TBX3, which had not been observed in previous studies on horse body size that displayed the highest differentiation and most significant association, and thus likely is the dominating factor for the small stature of the Debao pony.
TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells.
New
Tübingen, Germany. In Stem Cells Int, Dec 2015
TBX3 is a member of the T-box transcription factor family and is involved in the core pluripotency network.
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
New
Impact
Lausanne, Switzerland. In Cell, Nov 2015
Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features.
Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast.
Impact
Singapore, Singapore. In Cell Stem Cell, 2014
Here we use a combination of three small-molecule inhibitors to sustain hESCs in a LIF signaling-dependent hESC state (3iL hESCs) with elevated expression of NANOG and epiblast-enriched genes such as KLF4, DPPA3, and TBX3.
The T-box transcription factors TBX2 and TBX3 in mammary gland development and breast cancer.
Review
New York City, United States. In J Mammary Gland Biol Neoplasia, 2013
Ulnar mammary syndrome (UMS), an autosomal dominant disorder caused by mutations in TBX3, underscores the importance of TBX3 in human breast development, while abnormal mammary gland development in Tbx2 or Tbx3 mutant mice provides models for experimental investigation.
The landscape of cancer genes and mutational processes in breast cancer.
Impact
Sanger, United States. In Nature, 2012
Driver mutations were identified in several new cancer genes including AKT2, ARID1B, CASP8, CDKN1B, MAP3K1, MAP3K13, NCOR1, SMARCD1 and TBX3.
T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells.
GeneRIF
Amsterdam, Netherlands. In Cardiovasc Res, 2012
TBX3 reprogrammes terminally differentiated working cardiomyocytes and induces important pacemaker properties.
The ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb development.
GeneRIF
Cape Town, South Africa. In Mol Biol Cell, 2012
Data indicate the role and regulation of T-box transcription factor TBX3 in limb development.
Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation.
GeneRIF
Hannover, Germany. In Cell Mol Life Sci, 2012
Tbx2 and Tbx3 trigger development of the endocardial cushions through a regulatory feed-forward loop with Bmp2, thus providing a mechanism for the co-localization and coordination of these important processes in heart development.
Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells.
GeneRIF
San Francisco, United States. In Exp Cell Res, 2012
Tbx3 overexpression promotes squamous carcinoma cell survival displaying an epithelial-mesenchymal transition phenotype.
Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis.
GeneRIF
Salt Lake City, United States. In Proc Natl Acad Sci U S A, 2012
Tbx3 is required for the functional development, maturation, and homeostasis of the conduction system in a highly dosage-sensitive manner.
Alternative splicing of T-box transcription factor genes.
Review
Birmingham, United States. In Biochem Biophys Res Commun, 2011
Currently, TBX3, TBX5, and TBX20 are TBX genes defined to have multiple protein isoforms created by alternative splicing and characterized by expression and functional studies.
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
Impact
Tokyo, Japan. In Nat Genet, 2011
We identified genome-wide significant (P < 5 × 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3.
TBX2 and TBX3: the special value for anticancer drug targets.
Review
Guangzhou, China. In Biochim Biophys Acta, 2010
TBX2 and TBX3 are members of the T-box family of transcription factors, which are implicated in embryonic development.
omb and circumstance.
Review
Mainz, Germany. In J Neurogenet, 2008
The orthologous genes, TBX2 and TBX3, are found overexpressed or amplified in an increasing number of human cancers, emphasizing the importance of Tbx genes also in postdevelopmental processes.
Novel TBX3 mutation data in families with ulnar-mammary syndrome indicate a genotype-phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects.
Review
GeneRIF
Milano, Italy. In Eur J Med Genet, 2006
A literature review of TBX3 combined with a novel TBX3 mutation in a family with ulnar-mammary syndrome finds an association in mutations that disrupt the TBX3 DNA-binding domain and a higher frequency of severe upper limb malformations and teeth defects.
