LGR5/GPR49 is implicated in motor neuron specification in nervous system.
Tianjin, China. In Neurosci Lett, 2015
Furthermore, knockdown of LGR5 inhibited the expression of neuronal markers MAP2, NeuN, GAP43, SYP and CHRM3, and also reduced the expression of genes that program the identity of motor neurons, including Isl1, Lhx3, PHOX2A, TBX20 and NEUROG2.
Functionally significant, rare transcription factor variants in tetralogy of Fallot.
Newcastle upon Tyne, United Kingdom. In Plos One, 2013
GATA4, ISL1, TBX20, MEF2C, BOP/SMYD1, HAND2, FOXC1, FOXC2, FOXH, FOXA2 and TBX1) in 93 non-syndromic, non-Mendelian TOF cases.
Alternative splicing of T-box transcription factor genes.
Birmingham, United States. In Biochem Biophys Res Commun, 2011
Currently, TBX3, TBX5, and TBX20 are TBX genes defined to have multiple protein isoforms created by alternative splicing and characterized by expression and functional studies.