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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

T-box 20

Tbx20, hrT, T-box transcription factor Tbx20
This gene encodes a T-box family member. The T-box family members share a common DNA binding domain, termed the T-box, and they are transcription factors involved in the regulation of developmental processes. This gene is essential for heart development. Mutations in this gene are associated with diverse cardiac pathologies, including defects in septation, valvulogenesis and cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: Nkx2.5, HOS, Chordin, GATA4, CAN
Papers on Tbx20
TBX20 loss-of-function mutation associated with familial dilated cardiomyopathy.
Yang et al., In Clin Chem Lab Med, Mar 2016
METHODS: The coding regions and splicing junction sites of the TBX20 gene were sequenced in 120 unrelated patients with idiopathic DCM.
Genetic mutation analysis in Japanese patients with non-syndromic congenital heart disease.
Morisaki et al., Suita, Japan. In J Hum Genet, Nov 2015
We conducted sequence analysis of the coding regions of NKX2.5, GATA4, TBX1, TBX5, TBX20, CFC1 and ZIC3 in 111 Japanese patients with non-syndromic CHD and 9 of their relatives.
A genome-wide association study of suicidal behavior.
Mann et al., München, Germany. In Am J Med Genet B Neuropsychiatr Genet, Oct 2015
No SNP reached genome-wide significance, but several SNPs within STK3, ADAMTS14, PSME2, and TBX20 genes reached P < 1 × 10(-5) .
TBX20 loss-of-function mutation contributes to double outlet right ventricle.
Liu et al., Shanghai, China. In Int J Mol Med, Apr 2015
In the present study, the entire coding exons and flanking introns of the TBX20 gene, which codes for a T-box transcription factor essential for the proper development of the heart, were sequenced in a cohort of 146 unrelated patients with CHD.
Association of TBX20 gene polymorphism with congenital heart disease in Han Chinese neonates.
Zhang et al., Tianjin, China. In Pediatr Cardiol, Apr 2015
As a transcription factor mainly expressed in cardiovascular system, T-box 20 (TBX20) plays an important role in embryonic cardiovascular system development and adult heart function.
Comparative transcriptome profiling in human bicuspid aortic valve disease using RNA sequencing.
Semsarian et al., Sydney, Australia. In Physiol Genomics, Mar 2015
Upregulation of TBX20 was observed exclusively in BAVr compared with BAVc.
LGR5/GPR49 is implicated in motor neuron specification in nervous system.
Xue et al., Tianjin, China. In Neurosci Lett, 2015
Furthermore, knockdown of LGR5 inhibited the expression of neuronal markers MAP2, NeuN, GAP43, SYP and CHRM3, and also reduced the expression of genes that program the identity of motor neurons, including Isl1, Lhx3, PHOX2A, TBX20 and NEUROG2.
Novel mutations in the transcriptional activator domain of the human TBX20 in patients with atrial septal defect.
Vargas-Alarcón et al., Mexico. In Biomed Res Int, 2014
BACKGROUND: The relevance of TBX20 gene in heart development has been demonstrated in many animal models, but there are few works that try to elucidate the effect of TBX20 mutations in human congenital heart diseases.
A novel variant in TBX20 (p.D176N) identified by whole-exome sequencing in combination with a congenital heart disease related gene filter is associated with familial atrial septal defect.
Yang et al., Changsha, China. In J Zhejiang Univ Sci B, 2014
Previous studies have demonstrated that mutations in the transcription factor T-box 20 (TBX20) contribute to congenital ASD.
Functionally significant, rare transcription factor variants in tetralogy of Fallot.
Goodship et al., Newcastle upon Tyne, United Kingdom. In Plos One, 2013
GATA4, ISL1, TBX20, MEF2C, BOP/SMYD1, HAND2, FOXC1, FOXC2, FOXH, FOXA2 and TBX1) in 93 non-syndromic, non-Mendelian TOF cases.
Tbx20 promotes cardiomyocyte proliferation and persistence of fetal characteristics in adult mouse hearts.
Yutzey et al., Calcutta, India. In J Mol Cell Cardiol, 2013
The T-box transcription factor Tbx20 is necessary and sufficient to promote prenatal cardiomyocyte proliferation, and Tbx20 also is required for adult cardiac homeostasis.
Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis.
Cai et al., New York City, United States. In Development, 2013
Here, we report that the T-box transcription factor Tbx20 is expressed in the developing endocardial cushions and valves throughout heart development.
Genetic analysis of the TBX20 gene promoter region in patients with ventricular septal defects.
Yan et al., Jining, China. In Gene, 2012
Study identified one novel heterozygous sequence variant within the proximal promoter region of TBX20 gene in a ventricular septal defects patient, which inhibited transcriptional activities of TBX20 gene promoter; data provide new information to help understanding of genetic causes and molecular mechanisms of congenital heart disease.
Dual transcriptional activator and repressor roles of TBX20 regulate adult cardiac structure and function.
Nobrega et al., Chicago, United States. In Hum Mol Genet, 2012
a dual role for TBX20 as both a transcriptional activator and a repressor, and that each of these functions regulates genes with very specialized and distinct molecular roles
Probing the polygenic basis of cardiomyopathies in Drosophila.
Bodmer et al., Los Angeles, United States. In J Cell Mol Med, 2012
These include interactions between tinman/Nkx2-5 and neuromancer/Tbx20, which led to the discovery of possibly disease-causing familial variants in human TBX20.
Tbx20 regulation of cardiac cell proliferation and lineage specialization during embryonic and fetal development in vivo.
Yutzey et al., Cincinnati, United States. In Dev Biol, 2012
Data show distinct functions for Tbx20 in regulation of cardiomyocyte lineage maturation and cell proliferation at embryonic and fetal stages of heart development.
Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2.
Cai et al., New York City, United States. In Dev Biol, 2012
mice lacking Tbx20 in the atrioventricular canal myocardium fail to form the atrioventricular canal constriction, and the endocardial epithelial-mesenchymal transition (EMT) is severely perturbed.
Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function.
Evans et al., Los Angeles, United States. In J Clin Invest, 2011
Genome-wide ChIP analysis of Tbx20-binding regions in the adult heart revealed that many of these genes were direct downstream targets of Tbx20 and uncovered a previously undescribed DNA-binding site for Tbx20.
Alternative splicing of T-box transcription factor genes.
Jiao et al., Birmingham, United States. In Biochem Biophys Res Commun, 2011
Currently, TBX3, TBX5, and TBX20 are TBX genes defined to have multiple protein isoforms created by alternative splicing and characterized by expression and functional studies.
The molecular genetics of congenital heart disease: a review of recent developments.
Basson et al., New York City, United States. In Curr Opin Cardiol, 2010
along with the interaction of nkx2.7 with tbx20, have been elucidated.
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