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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

T-box 15

Tbx15
This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.[provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: Rspo3, MD-1, fibrillin-1, IP3R2, ADAMTS9
Papers on Tbx15
Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells.
New
Velázquez et al., Barcelona, Spain. In Apoptosis, Oct 2015
TBX15 is a T-box transcription factor that, recently, has been proposed as a marker in prostate cancer, but its function in carcinogenesis is unknown.
Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach.
Chen et al., Shenzhen, China. In Clin Epigenetics, 2014
Analysis of an additional 78 HCC pairs on the Illumina MiSeq platform confirmed that 7 genes showed either promoter hyper-methylation (SMAD6, IFITM1, LRRC4, CHST4, and TBX15) or hypo-methylation (CCL20 and NQO1) in HCC.
A genome-wide association study identifies multiple loci for variation in human ear morphology.
Ruiz-Linares et al., Puerto Madryn, Argentina. In Nat Commun, 2014
Two traits are associated with SNPs in a region overlapping the T-Box Protein 15 (TBX15) gene, a major determinant of mouse skeletal development.
Genome Wide Association Analysis Reveals New Production Trait Genes in a Male Duroc Population.
Li et al., Beijing, China. In Plos One, 2014
The Gene ontology analysis identified 14 candidate genes close to significant single nucleotide polymorphisms, with growth-related functions: six for days to 100 KG (WT1, FBXO3, DOCK7, PPP3CA, AGPAT9, and NKX6-1), seven for food conversion ratio (MAP2, TBX15, IVL, ARL15, CPS1, VWC2L, and VAV3), and one for average daily gain (COL27A1).
Multi-ethnic fine-mapping of 14 central adiposity loci.
Adrienne Cupples et al., Chapel Hill, United States. In Hum Mol Genet, 2014
Trans-ethnic analyses at five loci (TBX15-WARS2, LYPLAL1, ADAMTS9, LY86 and ITPR2-SSPN) substantially narrowed the signals to smaller sets of variants, some of which are in regions that have evidence of regulatory activity.
The genetics of fat distribution.
Review
Kovacs et al., Leipzig, Germany. In Diabetologia, 2014
Indeed, genes such as TBX15 not only manifest differential expression in various fat depots, but also correlate with obesity and related traits.
Fetal baboon sex-specific outcomes in adipocyte differentiation at 0.9 gestation in response to moderate maternal nutrient reduction.
Nathanielsz et al., Baton Rouge, United States. In Int J Obes (lond), 2014
The expression of genes/proteins involved in adipogenesis (PPARγ, FABP4 and adiponectin) and brown adipose tissue development (UCP1, TBX15 and COXIV) were determined in in vitro-differentiated stromal-vascular cultures from subcutaneous abdominal, subcutaneous femoral and omental adipose tissue depots.
Fat depot-specific mRNA expression of novel loci associated with waist-hip ratio.
Kovacs et al., Leipzig, Germany. In Int J Obes (lond), 2014
METHODS: Adipose tissue (AT) mRNA expression of 6 genes (TBX15/WARS2, STAB1, PIGC, ZNRF3 and GRB14) within these loci showing coincident cis-expression quantitative trait loci was measured in 222 paired samples of human visceral (vis) and subcutaneous (sc) AT.
Homozygosity for a novel truncating mutation confirms TBX15 deficiency as the cause of Cousin syndrome.
Unger et al., Lausanne, Switzerland. In Am J Med Genet A, 2013
Following its description in two sibs in 1982, no new cases have been observed until the observation of two unrelated cases in 2008 who were homozygous for frameshift mutations in TBX15.
Myogenic differential methylation: diverse associations with chromatin structure.
Ehrlich et al., New Orleans, United States. In Biology (basel), 2013
Lastly, despite its myogenesis-associated expression, TBX15 had multiple hypermethylated myogenic DMRs framing its promoter region.
Mosaic small supernumerary marker chromosome 1 at amniocentesis: prenatal diagnosis, molecular genetic analysis and literature review.
Review
Wang et al., Taipei, Taiwan. In Gene, 2013
We discuss the genotype-phenotype correlation of the involved genes of ALX3, RBM15, NTNG1, SLC25A24, GPSM2, TBX15 and NOTCH2 in this case.
A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations.
Impact
Shen et al., Nanjing, China. In Nat Genet, 2013
The combined analyses identified significant associations (P < 5.0 × 10⁻⁸) at 1p12 (rs2474937 near TBX15; odds ratio (OR) = 1.40;
Effect of maternal methionine supplementation on the transcriptome of bovine preimplantation embryos.
Khatib et al., Madison, United States. In Plos One, 2012
Interestingly, several of the most significant genes are related to embryonic development (e.g., VIM, IFI6, BCL2A1, and TBX15) and immune response (e.g., NKG7, TYROBP, SLAMF7, LCP1, and BLA-DQB).
Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
Fox et al., Boston, United States. In Plos Genet, 2012
divided by the number of independent SNPs within the region) in AA studied here (TBX15-WARS2, GRB14, ADAMTS9, LY86, RSPO3, ITPR2-SSPN).
Control of pelvic girdle development by genes of the Pbx family and Emx2.
GeneRIF
Selleri et al., New York City, United States. In Dev Dyn, 2011
Study establish that expression of Tbx15, Prrx1, and Pax1, among other genes involved in the specification and development of select pelvic structures, is altered in our compound mutants.
Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration.
GeneRIF
Kahn et al., Boston, United States. In Proc Natl Acad Sci U S A, 2011
Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration.
Combination of promoter hypomethylation and PDX1 overexpression leads to TBX15 decrease in vascular IUGR placentas.
GeneRIF
Vaiman et al., Paris, France. In Epigenetics, 2011
TBX15 might be involved in the pathophysiology of placental diseases.
Tbx18 and Tbx15 null-like phenotypes in mouse embryos expressing Tbx6 in somitic and lateral plate mesoderm.
GeneRIF
Chapman et al., Pittsburgh, United States. In Dev Biol, 2010
phenotypes result from competition between the ectopically expressed Tbx6 and the endogenously expressed Tbx18 and Tbx15 at the binding sites of target genes
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Impact
Lindgren et al., Regensburg, Germany. In Nat Genet, 2010
We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1.
TBX15 mutations cause craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature in Cousin syndrome.
GeneRIF
Superti-Furga et al., Freiburg, Germany. In Am J Hum Genet, 2008
TBX15 mutations cause craniofacial dysmorphism, hypoplasia of scapula and pelvis, and short stature in Cousin syndrome.
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