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proteins. Page last changed on 19 Aug 2016.
T-box brain gene 1
Tbr1, T brain, T-brain-1
This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Jul 2008] (from
NCBI)
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HAD, AGE, Brn-1, CAN, Eomes
Papers using
Tbr1
antibodies
Development of the catecholamine neurons in the human embryos and fetuses, with special emphasis on the innervation of the cerebral cortex
Supplier
In Cerebral Cortex (New York, NY), 1994
... TBR1Abcam, Cambridge, UK ...
Autolytic transition of mu-calpain upon activation as resolved by antibodies distinguishing between the pre- and post-autolysis forms.
Supplier
In PLoS ONE, 1991
... (1∶100, Abnova, Taipei, Taiwan), rabbit anti-Satb2 (1∶1000, Abcam, Cambridge, UK), rat anti-Ctip2 (1∶500, Abcam), rabbit anti-Tbr1 (1∶500, Abcam), rabbit anti-vGlut1 (1∶1000, Synaptic ...
Papers on
Tbr1
Speciation of two gobioid species, Pterogobius elapoides and Pterogobius zonoleucus revealed by multi-locus nuclear and mitochondrial DNA analyses.
New
Tokyo, Japan. In Gene, Mar 2016
Because morphological classification clearly distinguish these two species and a gene tree may differ from a population tree, we examined three nuclear genes, S7RP, RAG1, and TBR1, in this work, in order to determine whether nuclear and mitochondrial trees are concordant, thus shedding light on the evolutionary history of this group of fishes.
Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon.
New
Newcastle upon Tyne, United Kingdom. In J Anat, Dec 2015
In the cortex, TOP2B is expressed in cell nuclei in both proliferative (SVZ) and post-mitotic compartments (intermediate zone and cortical plate) as revealed by comparison with immunostaining for PAX6 and the post-mitotic neuron marker TBR1.
Distinct calcium signals in developing cortical interneurons persist despite disorganization of cortex by Tbr1 KO.
New
Seattle, United States. In Dev Neurobiol, Nov 2015
We examine Ca(2+) fluctuations in the first postnatal week of normal mouse neocortex and that expressing knockout of the transcription factor T-brain-1 (Tbr1): a signaling molecule in cortical patterning and differentiation of excitatory neurons.
Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes.
New
Leiden, Netherlands. In Age (dordr), Aug 2015
3-T brain MRI was used to detect macro-structural damage (atrophy, white matter hyper-intensities, infarcts and/or micro-bleeds) and magnetization transfer imaging (MTI) to detect loss of micro-structural homogeneity that remains otherwise invisible on conventional MRI.
Signal-to-noise ratio and parallel imaging performance of commercially available phased array coils in 3.0 T brain magnetic resonance imaging.
New
Shizuoka, Japan. In Radiol Phys Technol, Jul 2015
The signal-to-noise ratio (SNR) and parallel imaging (PI) performance of two commercial phased-array coils (PACs) were examined in magnetic resonance imaging (MRI) of the brain.
Brain-specific transcriptional regulator T-brain-1 controls brain wiring and neuronal activity in autism spectrum disorders.
Review
Taipei, Taiwan. In Front Neurosci, 2014
T-brain-1 (TBR1) is a brain-specific T-box transcription factor.
Parasitological, serological and molecular survey of Trypanosoma evansi infection in dromedary camels from Cholistan Desert, Pakistan.
Lahore, Pakistan. In Parasit Vectors, 2014
evansi, ELISA/VSG RoTat 1.2, immune trypanolysis) and molecular tests (TBR1/2 PCR and RoTat 1.2 PCR).
Tumor-to-background ratio to predict response to chemotherapy of osteosarcoma better than standard uptake values.
Review
Wuhan, China. In Orthop Surg, 2014
RESULTS: It was found that good responses are achieved in patients with TBR after chemotherapy (TBR2)/TBR before chemotherapy (TBR1) < 0.470 (positive predictive value [PPV] = 92.31%,
Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.
Impact
Seattle, United States. In Science, 2013
We estimate that recurrent disruptive mutations in six genes-CHD8, DYRK1A, GRIN2B, TBR1, PTEN, and TBL1XR1-may contribute to 1% of sporadic ASDs.
Transcriptional dysregulation of neocortical circuit assembly in ASD.
Review
Ann Arbor, United States. In Int Rev Neurobiol, 2012
Many of these TFs (TBR1, SOX5, FEZF2, and SATB2) have been implicated in ASD.
Dissecting the genomic complexity underlying medulloblastoma.
Impact
Heidelberg, Germany. In Nature, 2012
Several recurrent mutations were identified, both in known medulloblastoma-related genes (CTNNB1, PTCH1, MLL2, SMARCA4) and in genes not previously linked to this tumour (DDX3X, CTDNEP1, KDM6A, TBR1), often in subgroup-specific patterns.
TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract.
GeneRIF
New Haven, United States. In Proc Natl Acad Sci U S A, 2011
TBR1 is a direct transcriptional repressor of Fezf2 and a negative regulator of CS tract formation that restricts the laminar origin of CS axons specifically to L5.
Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development.
GeneRIF
Santa Cruz, United States. In J Neurosci, 2011
TBR1 promotes the identity of corticothalamic neurons and represses subcerebral fates through reducing expression of Fezf2 and CTIP2.
The T-box brain 1 (Tbr1) transcription factor inhibits astrocyte formation in the olfactory bulb and regulates neural stem cell fate.
GeneRIF
Madrid, Spain. In Mol Cell Neurosci, 2011
Results show that the expression of Tbr1 in neural stem and progenitor cells prevents them from following an astrocyte fate during olfactory bulb development.
Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.
GeneRIF
Seattle, United States. In Proc Natl Acad Sci U S A, 2010
Tbr1 coordinately regulates regional and laminar identity of postmitotic cortical neurons.
Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.
GeneRIF
Göttingen, Germany. In Proc Natl Acad Sci U S A, 2010
Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex
Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum.
Impact
Hamburg, Germany. In Nat Genet, 2008
CASK is a multi-domain scaffolding protein that interacts with the transcription factor TBR1 and regulates expression of genes involved in cortical development such as RELN.
How neuronal migration contributes to the morphogenesis of the CNS: insights from the zebrafish.
Review
Milano, Italy. In Dev Neurosci, 2007
The migration of a subgroup of mitral cell precursors from the dorsocaudal telencephalon to the olfactory bulb, visualized in the tg(tbr1:YFP) transgenic line, is coupled with morphogenetic transformation of the dorsal telencephalon.
The role of the MAGUK protein CASK in neural development and synaptic function.
Review
Taipei, Taiwan. In Curr Med Chem, 2005
These proteins, whose interactions with CASK are reviewed here, include the Parkinson's disease molecule parkin, the adhesion molecule neurexin, syndecans, calcium channel proteins, the cytoplasmic adaptor protein Mint1, Veli/mLIN-7/MALS, SAP97, caskin and CIP98, transcription factor Tbr-1, and nucleosome assembly protein CINAP.
Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2.
Impact
Boston, United States. In Nature, 2000
Here we report that, through its guanylate kinase domain, CASK interacts with Tbr-1, a T-box transcription factor that is involved in forebrain development.
