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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transducin

TBL2, WS-betaTRP
This gene encodes a member of the beta-transducin protein family. Most proteins of the beta-transducin family are involved in regulatory functions. This protein is possibly involved in some intracellular signaling pathway. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, TRIB1, Mio, UBIAD1, GCKR
Papers on TBL2
TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.
New
Tomida et al., Tokyo, Japan. In J Cell Biochem, Feb 2016
We previously showed that, upon ER stress, transducin (β)-like 2 (TBL2) was an ER-localized transmembrane protein and interacted with PERK and that TBL2 was involved in ATF4 expression and cell survival.
The endoplasmic reticulum-localized protein TBL2 interacts with the 60S ribosomal subunit.
New
Tomida et al., Tokyo, Japan. In Biochem Biophys Res Commun, Aug 2015
Transducin (beta)-like 2 (TBL2) is a poorly characterized protein comprising the N-terminal transmembrane region and the C-terminal WD40 domain.
Pleiotropic genes for metabolic syndrome and inflammation.
Borecki et al., Saint Louis, United States. In Mol Genet Metab, 2014
They map to genes MACF1, KIAA0754, GCKR, GRB14, COBLL1, LOC646736-IRS1, SLC39A8, NELFE, SKIV2L, STK19, TFAP2B, BAZ1B, BCL7B, TBL2, MLXIPL, LPL, TRIB1, ATXN2, HECTD4, PTPN11, ZNF664, PDXDC1, FTO, MC4R and TOMM40.
Study of yellow luminescence of binary terbium complexes based on 3,3',4,4'-biphthalic anhydride.
Ling et al., In Appl Opt, 2014
Three novel binary Tb(III) complexes (TbL2, TbL, and Tb2L; L=3,3',4,4'-biphenyl tetracarboxylic ligand) were synthesized by changing the molar ratio of Tb(III) to 3,3',4,4'-biphthalic anhydride (BPDA) (1∶2, 1∶1, and 2∶1, respectively).
TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress.
Tomida et al., Tokyo, Japan. In Plos One, 2013
Here we identify transducin (beta)-like 2 (TBL2) as a novel PERK-binding protein.
The TERE1 protein interacts with mitochondrial TBL2: regulation of trans-membrane potential, ROS/RNS and SXR target genes.
Malkowicz et al., Philadelphia, United States. In J Cell Biochem, 2013
To gain further insight into mechanisms of growth suppression and enzymatic regulation of TERE1 we isolated TERE1 associated proteins and identified the WD40 repeat, mitochondrial protein TBL2.
Ectopic expression of the TERE1 (UBIAD1) protein inhibits growth of renal clear cell carcinoma cells: altered metabolic phenotype associated with reactive oxygen species, nitric oxide and SXR target genes involved in cholesterol and lipid metabolism.
Malkowicz et al., Philadelphia, United States. In Int J Oncol, 2013
Based on the elevated cholesterol and altered metabolic phenotype of RCC, we also examined the effects of TERE1 and the interacting protein TBL2 on cellular cholesterol.
Association of the MLXIPL/TBL2 rs17145738 SNP and serum lipid levels in the Guangxi Mulao and Han populations.
Wang et al., Nanning, China. In Lipids Health Dis, 2012
BACKGROUND: The rs17145738 single nucleotide polymorphism (SNP) near MLX interacting protein-like/transducin (beta)-like 2 (MLXIPL/TBL2) loci is associated with serum lipid levels, but the results are inconsistent in diverse ethnic/racial groups.
RNAi-based functional profiling of loci from blood lipid genome-wide association studies identifies genes with cholesterol-regulatory function.
Runz et al., Heidelberg, Germany. In Plos Genet, 2012
CXCL12, FAM174A, PAFAH1B1, SEZ6L, TBL2, WDR12) that knockdown correlates with altered LDL-receptor levels and/or that overexpression as GFP-tagged fusion proteins inversely modifies cellular cholesterol levels.
The bladder tumor suppressor protein TERE1 (UBIAD1) modulates cell cholesterol: implications for tumor progression.
Malkowicz et al., Philadelphia, United States. In Dna Cell Biol, 2011
A role in lipid metabolism was suggested by TERE1 binding to APOE, a cholesterol carrier, and to TBL2, a candidate protein in triglyceride disorders.
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
Impact
Cho et al., South Korea. In Nat Genet, 2011
(in C12orf51 and near OAS1), 4q31.22 (in ZNF827) and 7q11.23 (near TBL2-BCL7B) for hepatic traits.
[Study on synthesis and fluorescence characterization of europium and terbium complexes of 1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl) ethanone].
Zhang et al., Nanning, China. In Guang Pu Xue Yu Guang Pu Fen Xi, 2010
Six solid complexes(TbL3 x 2H2O, TbL2 (phen) x H2O, TbL2 (TPPO), EuL3 x 2H2O, EuL2 (phen) x 2H2O and EuL2 (TPPO) x 2H2O) have been synthesized based on the pyrazole ligand(HL)(phen = 1,10-phenanthroline, TPPO = Tri-phenylphosphine oxide, HL=1-(5-(2-hydroxyphenyl)-3-methyl-4,5-dihydropyrazol-1-yl) ethanone).
A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.
GeneRIF
Wang et al., London, Canada. In Hum Mol Genet, 2009
Data show that SNPs associated with TG in normolipidemic samples, including APOA5, TRIB1, TBL2, GCKR, GALNT2 and ANGPTL3 were significantly associated with HLP types 2B, 3, 4 and 5.
Detection of nanomolar concentrations of copper(II) with a Tb-quinoline-2-one probe using luminescence quenching or luminescence decay time.
Samec et al., Regensburg, Germany. In Anal Chim Acta, 2009
TbL2 was tested for the effect of some relevant interferents and the assay was applied to the determination of copper in tap water samples.
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
Impact
Orho-Melander et al., Boston, United States. In Nat Genet, 2008
Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3).
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