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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TANK-binding kinase 1

TBK1, NaK, TANK-binding kinase 1
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: Interferon Regulatory Factor-3, CAN, V1a, ACID, RIG-I
Papers using TBK1 antibodies
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response
Supplier
Meurs Eliane F., In PLoS ONE, 2010
... Antibodies against TBK1 were purchased from Imgenex (San Diego, CA) and ...
MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcription.
Supplier
Rall Glenn F., In PLoS Pathogens, 2006
... The optineurin, TBK1, TRAF3 and HA antibodies were obtained from Abcam.
Negative and positive regulation of gene expression by mouse histone deacetylase 1
Supplier
Superti-Furga Giulio et al., In The EMBO Journal, 2005
... The TBK1-specific antiserum was obtained from Cell Signaling.
Summaries of Affymetrix GeneChip probe level data.
Supplier
Thiel Volker, In PLoS ONE, 2002
... The following commercially available antibodies were used for immunoblotting or immunofluorescence: anti-TBK1 (Cell Signaling), anti-Myc-IRDye 800 (Rockland), anti-Myc ...
The small envelope protein E is not essential for murine coronavirus replication.
Supplier
Ryu Wang-Shick, In PLoS ONE, 2002
... Tbk1 gene was PCR subcloned into different pCMV vectors (Clontech) in between ...
Papers on TBK1
Defects in autophagy caused by glaucoma-associated mutations in optineurin.
Review
New
Swarup et al., Hyderābād, India. In Exp Eye Res, Mar 2016
The E50K mutant also causes other changes in the cells such as altered interaction with TBK1 protein kinase, aggregate formation, generation of reactive oxygen species and inhibition of proteasome, which may contribute to pathogenesis.
Target identification in small cell lung cancer via integrated phenotypic screening and activity-based protein profiling.
New
Haura et al., Fort Lee, United States. In Mol Cancer Ther, Feb 2016
We next extended the platform to a second compound that had activity in SCLC cell lines lacking c-MYC amplification and identified TANK-binding kinase 1 (TBK1), a kinase that affects cell viability, polo-like kinase-1 signaling, G2/M arrest, and apoptosis in SCLC cells lacking MYC amplification.
Bacterial E3 Ubiquitin Ligase IpaH4.5 of Shigella flexneri Targets TBK1 To Dampen the Host Antibacterial Response.
New
He et al., Beijing, China. In J Immunol, Jan 2016
Their activation is tightly regulated by TANK-binding kinase 1 (TBK1).
[Effect of the cytoplasmic DNA sensor DAI on replication of hepatitis B virus].
New
Yang et al., China. In Zhonghua Gan Zang Bing Za Zhi, Jan 2016
Next, the HepG2 cells were triple transfected with siRNA targeting the type I interferon pathway molecule TBK1 and DAI simultaneously and HBV1.3, after which HBV viral proteins were detected.
Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort.
New
Belgian Neurology consortium et al., Edegem, Belgium. In Brain, Jan 2016
UNASSIGNED: We identified in a cohort of patients with frontotemporal dementia (n = 481) or amyotrophic lateral sclerosis (n = 147), 10 index patients carrying a TBK1 loss of function mutation reducing TBK1 expression by 50%.
TCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complex.
Review
New
Sun et al., Baoding, China. In Mol Immunol, Dec 2015
Recent evidence suggests that CARMA1 also mediates TCR/CD28-stimulated activation of the IKK-related kinase TBK1, which plays a role in regulating the homeostasis and migration of T cells.
Expanding the ubiquitin code through post-translational modification.
Review
New
Dikic et al., Frankfurt am Main, Germany. In Embo Rep, Sep 2015
Similarly, TBK1 phosphorylates the autophagy receptors OPTN and p62 to initiate feedback and feedforward programs for Ub-dependent removal of protein aggregates, mitochondria and pathogens (such as Salmonella and Mycobacterium tuberculosis).
RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity.
Review
New
Soto-Rifo et al., Santiago, Chile. In Rev Med Virol, Sep 2015
As such, DDX3 has been shown to play roles both upstream and downstream of I-kappa beta kinase ε (IKKε)/TANK-binding kinase 1, leading to IFN-β production.
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.
New
Impact
Goldstein et al., Durham, United States. In Science, Apr 2015
Several known ALS genes were found to be associated, and TBK1 (the gene encoding TANK-binding kinase 1) was identified as an ALS gene.
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation.
New
Impact
Chen et al., Dallas, United States. In Science, Apr 2015
Here we show that MAVS and STING harbor two conserved serine and threonine clusters that are phosphorylated by the kinases IKK and/or TBK1 in response to stimulation.
The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.
Impact
Wang et al., Shanghai, China. In Immunity, 2015
This modification served as an anchoring platform for recruiting TANK-binding kinase 1 (TBK1) and facilitating its translocation to the perinuclear microsomes.
Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis.
Chellappan et al., Tampa, United States. In Nat Commun, 2014
TANK Binding Kinase 1 (TBK1) is a non-canonical IκB kinase that contributes to KRAS-driven lung cancer.
An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.
Impact
Cheresh et al., San Diego, United States. In Nat Cell Biol, 2014
Mechanistically, α(v)β₃, in the unliganded state, recruits KRAS and RalB to the tumour cell plasma membrane, leading to the activation of TBK1 and NF-κB.
TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.
Impact
Pearce et al., Saint Louis, United States. In Nat Immunol, 2014
Signaling via the kinases TBK1, IKKɛ and Akt was essential for the TLR-induced increase in glycolysis by promoting the association of the glycolytic enzyme HK-II with mitochondria.
Innate Immune Signaling by, and Genetic Adjuvants for DNA Vaccination.
Review
Ishii et al., Ibaraki, Japan. In Vaccines (basel), 2012
Recent studies have shown that immunogenicity of DNA vaccines are regulated by innate immune responses via plasmid DNA recognition through the STING-TBK1 signaling cascade.
ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.
GeneRIF
Zhu et al., Tallahassee, United States. In J Virol, 2012
phosphorylation of IRF7 on Ser477 and Ser479 by IKKepsilon or TBK1 is inhibited by KSHV ORF45
Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood.
GeneRIF
Casanova et al., New York City, United States. In J Exp Med, 2012
TBK1 is essential for the TLR3- and IFN-dependent control of HSV-1 in the central nervous system
TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation.
Impact
GeneRIF
Deretic et al., Albuquerque, United States. In Immunity, 2012
TBK-1 was necessary for autophagic maturation, it coordinated assembly and function of the autophagic machinery and phosphorylated the autophagic adaptor p62 (sequestosome 1) on Ser-403, a residue essential for its role in autophagic clearance.
Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
GeneRIF
Dueber et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2012
TBK1 autoactivation and substrate specificity are likely driven by signal-dependent colocalization events
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.
GeneRIF
Chen et al., Dallas, United States. In Sci Signal, 2012
results suggest that STING functions as a scaffold protein to specify and promote the phosphorylation of IRF3 by TBK1.
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