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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

TBC1 domain family, member 3

TBC1D3, prostate cancer gene 17
Papers on TBC1D3
TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity.
Stahl et al., Saint Louis, United States. In Plos One, 2011
TBC1D3 plays an unanticipated and potentially unique role in the fine-tuning of insulin/IGF-1 signaling
The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking.
Stahl et al., Saint Louis, United States. In J Biol Chem, 2008
Altered growth factor receptor trafficking and GTP-Ras turnover may be sites where recently evolved genes such as TBC1D3 selectively modulate signaling in hominoids and humans
TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.
Stahl et al., Saint Louis, United States. In Genomics, 2006
We describe eight highly related TBC1D3 paralogues located on Chromosome 17q12 that display specific transcription patterns in human tissues, and that pattern is altered in several primary prostate tumors in comparison to healthy prostate tissues.
PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.
Li et al., San Francisco, United States. In Cancer Res, 2002
PRC17 is amplified in 15% of prostate cancers, it is highly overexpressed in approximately one-half of metastatic prostate tumors.
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