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TBC1 domain family, member 3

TBC1D3, prostate cancer gene 17
Top mentioned proteins: Rab5, TBC, fibrillin-1, p185, GAP
Papers on TBC1D3
Crystal structure of a Chlamydomonas reinhardtii flagellar RabGAP TBC-domain at 1.8 Å resolution.
Lorentzen et al., Martinsried, Germany. In Proteins, 2014
BLAST searches revealed potential human orthologues of CrfRabGAP as TBC1D3 and TBC1D26.
Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling.
Shen et al., Nanjing, China. In Plos One, 2013
The hominoid oncogene TBC1D3 enhances epidermal growth factor receptor (EGFR) signaling and induces cell transformation.
Genomic DNA in human blastocoele fluid.
Bulletti et al., Cattolica, Italy. In Reprod Biomed Online, 2013
Moreover, the potential for determining embryo sex directly from blastocoele fluid is demonstrated by amplifying the multicopy genes TSPY1 (on the Y chromosome) and TBC1D3 (on chromosome 17).
Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylation.
Stahl et al., Saint Louis, United States. In Biochem Biophys Res Commun, 2013
Expression of the hominoid-specific oncoprotein TBC1D3 promotes enhanced cell growth and proliferation by increased activation of signal transduction through several growth factors.
TBC1D3, a hominoid-specific gene, delays IRS-1 degradation and promotes insulin signaling by modulating p70 S6 kinase activity.
GeneRIF
Stahl et al., Saint Louis, United States. In Plos One, 2011
TBC1D3 plays an unanticipated and potentially unique role in the fine-tuning of insulin/IGF-1 signaling
Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is mediated by CUL7 E3 ligase.
Stahl et al., Saint Louis, United States. In Plos One, 2011
Expression of the hominoid-specific TBC1D3 oncoprotein enhances growth factor receptor signaling and subsequently promotes cellular proliferation and survival.
Human-specific genes may offer a unique window into human cell signaling.
Review
Wainszelbaum et al., Saint Louis, United States. In Sci Signal, 2008
Investigation of the gene encoding TBC1D3 is one example of a search that may lead to understanding the evolution and the function of human-specific genes, because it is absent in lower species and present in high copy number in the human genome.
The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking.
GeneRIF
Stahl et al., Saint Louis, United States. In J Biol Chem, 2008
Altered growth factor receptor trafficking and GTP-Ras turnover may be sites where recently evolved genes such as TBC1D3 selectively modulate signaling in hominoids and humans
The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway.
Confalonieri et al., Milano, Italy. In Mol Biol Cell, 2008
One such case is represented by TBC1D3, a primate-specific gene, harboring a TBC domain.
TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.
GeneRIF
Stahl et al., Saint Louis, United States. In Genomics, 2006
We describe eight highly related TBC1D3 paralogues located on Chromosome 17q12 that display specific transcription patterns in human tissues, and that pattern is altered in several primary prostate tumors in comparison to healthy prostate tissues.
The Tre2 (USP6) oncogene is a hominoid-specific gene.
Haber et al., United States. In Proc Natl Acad Sci U S A, 2003
We report here that the Tre2 (USP6) oncogene is derived from the chimeric fusion of two genes, USP32 (NY-REN-60), and TBC1D3.
PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.
GeneRIF
Li et al., San Francisco, United States. In Cancer Res, 2002
PRC17 is amplified in 15% of prostate cancers, it is highly overexpressed in approximately one-half of metastatic prostate tumors.
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