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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TBC1

TBC
TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: HAD, Rab5, CAN, GAP, TRE2
Papers on TBC
TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic.
New
Tooze et al., Frankfurt am Main, Germany. In Embo J, Jan 2016
We have previously identified the TBC domain-containing protein, TBC1D14, as a negative regulator of autophagy that controls delivery of membranes from RAB11-positive recycling endosomes to forming autophagosomes.
The evolutionarily conserved Tre2/Bub2/Cdc16 (TBC), Lysin motif (LysM), Domain catalytic (TLDc) domain is neuroprotective against oxidative stress.
New
Oliver et al., Oxford, United Kingdom. In J Biol Chem, Jan 2016
OXR1 contains the Tre2/Bub2/Cdc16 (TBC), Lysin motif (LysM), Domain catalytic (TLDC) domain, a motif present in a family of proteins including TBC1 domain family member 24 (TBC1D24), a protein mutated in a range of disorders characterized by seizures, hearing loss and neurodegeneration.
Expression study of GLUT4 translocation-related genes in a porcine pre-diabetic model.
New
Cirera et al., Frederiksberg, Denmark. In Mamm Genome, Dec 2015
Three of the genes, TBC (Tre-2, BUB2, CDC16) 1 Domain Family Member 4 (TBC1D4), insulin receptor and GLUT4 showed altered expression in some of the tissues.
The integration of autophagy and cellular trafficking pathways via RAB GAPs.
New
Behl et al., Mainz, Germany. In Autophagy, Nov 2015
A role in macroautophagy regulation for different TRE2-BUB2-CDC16 (TBC) domain-containing RAB GAPs has been established.
Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes.
New
Grant et al., United States. In Plos Genet, Sep 2015
Here we focused on the recycling function of the early endosome and the regulation of RAB-5 by GAP protein TBC-2 in the basolateral C. elegans intestine.
Effect of farm characteristics and practices on hygienic quality of ovine raw milk used for artisan cheese production in central Italy.
Review
New
Tonucci et al., Urbino, Italy. In Anim Sci J, Sep 2015
Analyzed variables were: (i) chemical parameters such as fat, protein and lactose content, dry matter and pH; and (ii) total bacterial (TBC) and somatic cell counts (SCC).
[Isolation, Identification of a p-tert-Butylcatechol-Degradaing Strains and Optimization for Its Degradation by Response Surface Methodology].
New
Huang et al., In Huan Jing Ke Xue, Jul 2015
A bacterial strain YHl that used p-tert-Butylcatechol (TBC) as the sole carbon and energy source was isolated from the activated sludge of the wastewater treatment plant of a chemical factory.
Cell mechanisms of gustatory lipids perception and modulation of the dietary fat preference.
Review
Khan et al., Dijon, France. In Biochimie, 2014
We demonstrate that linoleic acid (LA) by activating sPLA2, cPLA2 and iPLA2 via CD36, produced arachidonic acid (AA) and lyso-phosphatidylcholine (Lyso-PC) which triggered Ca(2+) influx in CD36-positive taste bud cells (TBC), purified from mouse CVP.
Toxicants target cell junctions in the testis: Insights from the indazole-carboxylic acid model.
Review
Cheng, New York City, United States. In Spermatogenesis, 2014
These include the basal tight junctions between Sertoli cells that form the main component of the blood-testis barrier, the basal ectoplasmic specializations (basal ES) and basal tubulobulbar complexes (basal TBC) between Sertoli cells; as well as apical ES and apical TBC between Sertoli cells and the developing spermatids that orchestrate spermiogenesis and spermiation.
Current models of mammalian target of rapamycin complex 1 (mTORC1) activation by growth factors and amino acids.
Review
Wang et al., Hohhot, China. In Int J Mol Sci, 2013
The mTOR-Rheb-TSC-TBC complex co-localizes to the lysosome and the phosphorylation of TSC-TBC effects the dissociation of the complex from the lysosome and activates Rheb.
[Screening for opportunistic infections and vaccination before introduction of biologic therapy].
Review
Vince et al., Zagreb, Croatia. In Acta Med Croatica, 2013
In order to introduce anti-TNFalpha therapy, screening for hepatitis viruses B and C, HIV, EBV, HPV, TBC, bacterial, fungal and parasitic infections should be performed.
Illuminating the functional and structural repertoire of human TBC/RABGAPs.
Review
Impact
Braga et al., London, United Kingdom. In Nat Rev Mol Cell Biol, 2012
The Tre2-Bub2-Cdc16 (TBC) domain-containing RAB-specific GTPase-activating proteins (TBC/RABGAPs) are characterized by the presence of highly conserved TBC domains and act as negative regulators of RABs.
Exercise increases TBC1D1 phosphorylation in human skeletal muscle.
GeneRIF
Goodyear et al., Boston, United States. In Am J Physiol Endocrinol Metab, 2011
A single bout of exercise regulates TBC1D1 and AS160 phosphorylation on multiple sites in human skeletal muscle.
Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
GeneRIF
Shoelson et al., Boston, United States. In J Biol Chem, 2011
Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
Enhancing Milk Preservation with Esterified Legume Proteins.
Osman et al., Az Zaqāzīq, Egypt. In Probiotics Antimicrob Proteins, 2011
Supplementation of raw milk with esterified legume proteins could ameliorate its preservation quality at 4 °C for 5 days, based on the total bacterial count (TBC) or the titratable acidity levels.
Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle.
GeneRIF
Wojtaszewski et al., Copenhagen, Denmark. In J Physiol, 2010
TBC1D1 is Ser237 phosphorylated and binding capacity to 14-3-3 protein is increased in skeletal muscle following exercise.
Of mice and men: filling gaps in the TBC1D1 story.
GeneRIF
Cartee, Ann Arbor, United States. In J Physiol, 2010
[review] The question of a mechanism for increased phosphorylation of Ser237-TBC1D1 after exercise has, so far, not had a straightforward experimental approach for a direct answer in humans undergoing in vivo exercise.
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity.
Impact
Al-Hasani et al., Potsdam, Germany. In Nat Genet, 2008
Here we identify a SJL-specific mutation in the Tbc1d1 gene that results in a truncated protein lacking the TBC Rab-GTPase-activating protein domain.
R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population.
GeneRIF
Froguel et al., Lille, France. In Hum Mol Genet, 2008
These results confirm a putative role of TBC1D1 R125W variant in familial obesity predisposition.
TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.
Impact
Lambright et al., Worcester, United States. In Nature, 2006
Proteins containing TBC (Tre-2, Bub2 and Cdc16) domains are broadly conserved in eukaryotic organisms and function as GAPs for Rab GTPases as well as GTPases that control cytokinesis.
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