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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tafazzin

TAZ, G4.5, G-4
This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: YAP, CAN, ACID, V1a, HAD
Papers on TAZ
Surface topography of hydroxyapatite promotes osteogenic differentiation of human bone marrow mesenchymal stem cells.
New
Qian et al., Shaoxing, China. In Mater Sci Eng C Mater Biol Appl, Apr 2016
On this surface configuration of HA, hBMSCs showed oriented attachment, F-actin arrangement, and a peak in the expression of Yes-associated protein (YAP) and PDZ binding motif (TAZ) (YAP/TAZ).
The Hippo pathway as drug targets in cancer therapy and regenerative medicine.
New
Hata et al., Tokyo, Japan. In Curr Drug Targets, Feb 2016
UNASSIGNED: Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ) co-operate with numerous transcription factors to regulate gene transcriptions.
MYC Indirectly Represses YAP/TAZ Activity in Mammary Tumors.
New
In Cancer Discov, Feb 2016
UNASSIGNED: MYC indirectly inhibits YAP/TAZ activity to promote growth of mammary tumors.
Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.
New
Suzuki et al., Fukuoka, Japan. In Proc Natl Acad Sci U S A, Feb 2016
These changes are strongly dependent on Yes-Associated Protein-1 (Yap1) and partially dependent on PDZ-binding motif (Taz) and Tgfbr2, but independent of connective tissue growth factor (Ctgf).
Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling.
New
Cunningham et al., San Francisco, United States. In Structure, Feb 2016
TEADs, with their co-activators YAP/TAZ, are critical for controlling cell differentiation and organ size through their transcriptional activation of genes involved in cell growth and proliferation.
Yap and Taz play a crucial role in neural crest-derived craniofacial development.
New
Martin et al., Houston, United States. In Development, Jan 2016
We used the Wnt1(Cre) and Wnt1(Cre2SOR) drivers to conditionally ablate both Yap and Taz in the CNC of mice.
Hippo pathway and breast cancer stem cells.
Review
New
De Maria et al., Roma, Italy. In Crit Rev Oncol Hematol, Jan 2016
Altered Hippo activity, or Hippo-independent mechanisms, mediate the activation of the Hippo transducers TAZ and YAP.
A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.
New
Impact
Eilers et al., Würzburg, Germany. In Cancer Cell, Jan 2016
This change in gene expression indirectly inhibits the YAP/TAZ co-activators, which maintain the clonogenic potential of these cells.
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer.
Review
New
Impact
Guan et al., Shanghai, China. In Cell, Dec 2015
By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status.
YAP and TAZ Take Center Stage in Cancer.
Review
New
Hong et al., Tianjin, China. In Biochemistry, Dec 2015
In the Hippo pathway, MST1/2 and LATS1/2 regulate downstream transcription coactivators YAP and TAZ, which mainly interact with TEAD family transcription factors to promote tissue proliferation, self-renewal of normal and cancer stem cells, migration, and carcinogenesis.
Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction.
Review
New
Dupont, Padova, Italy. In Exp Cell Res, Nov 2015
We here discuss recent advances on how mechanical signals intersect nuclear transcription and in particular the activity of YAP/TAZ transcriptional coactivators, known downstream transducers of the Hippo pathway and important effectors of ECM mechanical cues.
Control of proliferation and cancer growth by the Hippo signaling pathway.
Review
New
Sage et al., Stanford, United States. In Mol Cancer Res, Nov 2015
Furthermore, the oncogenic and tumor suppressive attributes of YAP/TAZ are reviewed which emphasizes the relevance of the Hippo pathway in cancer.
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth.
New
Impact
Piccolo et al., Padova, Italy. In Nat Cell Biol, Sep 2015
YAP/TAZ are nuclear effectors of the Hippo pathway regulating organ growth and tumorigenesis.
Alternative Wnt Signaling Activates YAP/TAZ.
New
Impact
Guan et al., San Diego, United States. In Cell, Sep 2015
The transcriptional co-activators YAP and TAZ are key regulators of organ size and tissue homeostasis, and their dysregulation contributes to human cancer.
The emerging roles of YAP and TAZ in cancer.
Review
New
Impact
Guan et al., San Diego, United States. In Nat Rev Cancer, Feb 2015
Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis.
Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
Impact
GeneRIF
Piccolo et al., Leuven, Belgium. In Nat Rev Mol Cell Biol, 2012
Studies indicate that the transcriptional co-activators YAP and TAZ recently emerged as key mediators of the biological effects that are observed in response to extracellular matrix (ECM) elasticity and cell shape.
The N-terminal phosphodegron targets TAZ/WWTR1 protein for SCFβ-TrCP-dependent degradation in response to phosphatidylinositol 3-kinase inhibition.
GeneRIF
Guan et al., Shanghai, China. In J Biol Chem, 2012
a novel mechanism of TAZ regulation and role of TAZ in modulating tissue growth and tumor development in response to PI3K signaling.
Lentivirus-mediated RNA interference targeting WWTR1 in human colorectal cancer cells inhibits cell proliferation in vitro and tumor growth in vivo.
GeneRIF
Huang et al., Fuzhou, China. In Oncol Rep, 2012
WWTR1 is an oncogene and has an important role in the proliferation of colorectal cancer cells and in tumor growth in vivo.
Prognostic significance of TAZ expression in resected non-small cell lung cancer.
GeneRIF
Zhao et al., Guangzhou, China. In J Thorac Oncol, 2012
High TAZ expression is associated with non-small cell lung cancer.
Monoclonality of multifocal epithelioid hemangioendothelioma of the liver by analysis of WWTR1-CAMTA1 breakpoints.
GeneRIF
Antonescu et al., New York City, United States. In Cancer Genet, 2012
Using reverse transcription-polymerase chain reaction (RT-PCR) and subsequent sequencing, we confirmed an identical WWTR1-CAMTA1 fusion transcript product from different nodules in each patient.
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