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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cleavage stimulation factor, 3' pre-RNA subunit 2, tau

tauCstF-64, Cstf2t, mtauCstF-64
Top mentioned proteins: CstF-64, HAD, AGE, OUT, sp56
Papers on tauCstF-64
τCstF-64 Mediates Correct mRNA Polyadenylation and Splicing of Activator and Repressor Isoforms of the Cyclic AMP-Responsive Element Modulator (CREM) in Mouse Testis.
New
MacDonald et al., In Biol Reprod, Jan 2016
We found that the testis-expressed paralog of CstF-64, τCstF-64 (gene symbol Cstf2t) is involved in a polyadenylation site choice switch of Crem mRNA and leads to an overall decrease of the Crem mRNAs that are generated from internal promoters in Cstf2t(-/-) mice.
Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
Mayeux et al., New York City, United States. In Front Genet, 2012
These two loci harbor a number of novel candidate genes with SNPs, and our gene-wise association analysis identified multiple genes, including DCAF7, POLG2, CEP95, and SMURF2 at 17q23.2; and RASGEF1A, HNRNPF, ANF487, CSTF2T, and PRKG1 at 10q11.21.
The τCstF-64 polyadenylation protein controls genome expression in testis.
MacDonald et al., Newark, United States. In Plos One, 2011
The τCstF-64 polyadenylation protein (gene symbol Cstf2t) is a testis-expressed orthologue of CstF-64.
Spermatogenetic but not immunological defects in mice lacking the τCstF-64 polyadenylation protein.
GeneRIF
MacDonald et al., Lubbock, United States. In J Reprod Immunol, 2011
primarily supports spermatogenesis, but only incidently supports immune cell function
Infertility with impaired zona pellucida adhesion of spermatozoa from mice lacking TauCstF-64.
GeneRIF
MacDonald et al., Lubbock, United States. In Biol Reprod, 2010
tauCstF-64 is required not only for expression of genes involved in morphological differentiation of spermatids but also for genes having products that function during interaction of motile spermatozoa with eggs.
Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation.
GeneRIF
Shih et al., Taiwan. In Plos Pathog, 2009
Studied expression levels of CstF-64 in EV71-infected cells; showed reduction of CstF-64 during virus infection correlated with production of viral 3C(pro). CstF-64 was cleaved in vitro by 3C(pro) not by mutant 3C(pro) variants.
A family of splice variants of CstF-64 expressed in vertebrate nervous systems.
GeneRIF
Macdonald et al., Lubbock, United States. In Bmc Mol Biol, 2008
The Cstf2t protein contributes to proteomic diversity by regulating alternative polyadenylation of neural mRNAs.
Gene expression patterns of hippocampus and cerebral cortex of senescence-accelerated mouse treated with Huang-Lian-Jie-Du decoction.
Zhang et al., Beijing, China. In Neurosci Lett, 2008
The results showed that HL has the significant modulating effects on age-related changes of the gene expressions in the hippocampus and cerebral cortex in SAMP8, which include genes that involved in signal transduction (Dusp12, Rps6ka1, Rab26, Penk1, Nope, Leng8, Syde1, Phb, Def8, Ihpk1, Tac2, Pik3c2a), protein metabolism (Ttc3, Amfr, Prr6, Ube2d2), cell growth and development (Ngrn, Anln, Dip3b, Acrbp), nucleic acid metabolism (Fhit, Itm2c, Cstf2t, Ddx3x, Ercc5, Pcgfr6), energy metabolism (Stub1, Uqcr, Nsf), immune response (C1qb), regulation of transcription (D1ertd161e, Gcn5l2, Ssu72), transporter (Slc17a7, mt-Co1), nervous system development (Trim3), neurogila cell differentiation (Tspan2) and 24 genes whose biological function and process were still unknown.
Loss of polyadenylation protein tauCstF-64 causes spermatogenic defects and male infertility.
GeneRIF
Macdonald et al., Lubbock, United States. In Proc Natl Acad Sci U S A, 2008
Targeted disruption of Cstf2t in mice causes aberrant spermatogenesis, specifically disrupting meiotic and postmeiotic development, resulting in male infertility resembling oligoasthenoteratozoospermia.
Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers.
GeneRIF
Dass et al., Lubbock, United States. In Biochem J, 2007
tauCstF-64 promotes germ-cell-specific patterns of polyadenylation by binding to different downstream sequence elements.
The mRNA encoding tauCstF-64 is expressed ubiquitously in mouse tissues.
GeneRIF
MacDonald et al., Lubbock, United States. In Ann N Y Acad Sci, 2005
These results suggest the hypothesis that tauCstF-64 mRNA is regulated at the translational or post-translational level.
Developmental distribution of the polyadenylation protein CstF-64 and the variant tauCstF-64 in mouse and rat testis.
MacDonald et al., Lubbock, United States. In Biol Reprod, 2004
The second form, tauCstF-64 (encoded by the autosomal gene Cstf2t), is expressed in a more limited set of tissues and cell types, largely in meiotic and postmeiotic male germ cells and, to a smaller extent, in brain.
The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein tauCstF-64, lacks introns and may be associated with male sterility.
GeneRIF
MacDonald et al., Lubbock, United States. In Genomics, 2002
Radiation hybrid mapping places the human tauCstF-64 gene at 10q22-q23, which is the site of a translocation that has been associated with human neurological problems and male infertility.
Reexamining the polyadenylation signal: were we wrong about AAUAAA?
Review
Redondo et al., Lubbock, United States. In Mol Cell Endocrinol, 2002
Recent research in our laboratory has uncovered a new form of an essential polyadenylation protein, tauCstF-64, that is most highly expressed in male germ cells, and to a smaller extent in the brain, and which we propose plays a significant role in AAUAAA-independent mRNA polyadenylation in germ cells.
The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice.
MacDonald et al., Lubbock, United States. In J Biol Chem, 2001
We have named the variant form "tau CstF-64," and we describe here the cloning and characterization of the mouse tauCstF-64 cDNA, which maps to chromosome 19.
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