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Potassium channel, subfamily K, member 15

TASK-5, hTASK-5, KCNK15, KT3.3
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TASK-3, ACID, Rdl, TREK-1, TRAAK
Papers on TASK-5
Whole genome methylation analyses of schizophrenia patients before and after treatment.
Toncheva et al., Sofia, Bulgaria. In Biotechnol Biotechnol Equip, 2014
We found significant differences in the methylation profiles between male schizophrenia patients with complete remission and control male pool before treatment (C16orf70, CST3, DDRGK1, FA2H, FLJ30058, MFSD2B, RFX4, UBE2J1, ZNF311) and male schizophrenia patients with complete remission and control male pool after treatment (AP1S3, C16orf59, KCNK15, LOC146336, MGC16384, XRN2) that potentially could be used as target genes for new therapeutic strategies as well as markers for good treatment response.
Human metastable epiallele candidates link to common disorders.
Kellermayer et al., Houston, United States. In Epigenetics, 2013
DNA methylation changes at a number of these genes have been linked to various forms of human disease, including cancers, such as asthma and acute myeloid leukemia (ALOX12), gastric cancer (EBF3), breast cancer (NAV1), colon cancer and acute lymphoid leukemia (KCNK15), Wilms tumor (protocadherin gene cluster; PCDHAs) and colorectal cancer (TCERG1L), suggesting a potential etiologic role for MEs in tumorigenesis and underscoring the possible developmental origins of these malignancies.
The human carotid body transcriptome with focus on oxygen sensing and inflammation--a comparative analysis.
Eriksson et al., Stockholm, Sweden. In J Physiol, 2012
In the TASK subfamily of K+ channels, TASK-1 is expressed in human CBs, while TASK-3 and TASK-5 are absent, although we demonstrated both TASK-1 and TASK-3 in one of the mouse reference strains.
Immunocytochemical localization of TASK-3 (K(2P)9.1) channels in monoaminergic and cholinergic neurons.
Veh et al., Berlin, Germany. In Cell Mol Neurobiol, 2011
After removal of cross-reactivities and affinity purification the antibody was characterized by ELISA, immunocytochemistry of TASK-3 transfected cells, and Western blots indicating that the antibody only detects TASK-3 protein, but not its paralogs TASK-1 and TASK-5.
Changes in neuronal activity and gene expression in guinea-pig auditory brainstem after unilateral partial hearing loss.
Robertson et al., Australia. In Neuroscience, 2009
Expression of glutamate decarboxylase 1 (GAD1), GABA-A receptor subunit alpha-1 (GABRA1), and potassium channel subfamily K member 15 (KCNK15) was decreased ipsilaterally in the cochlear nucleus and bilaterally in the inferior colliculus.
Deafness associated changes in two-pore domain potassium channels in the rat inferior colliculus.
Altschuler et al., Ann Arbor, United States. In Neuroscience, 2007
TASK-1, TASK-5 and THIK-2 showed significant decreases in expression at all three times assessed.
Short-term effects of adolescent methylphenidate exposure on brain striatal gene expression and sexual/endocrine parameters in male rats.
Laviola et al., Roma, Italy. In Ann N Y Acad Sci, 2006
The latter included genes for: K+ channels (TASK-1, TASK-5), intercellular junctions (connexin30), neurotransmitter receptors (adrenergic alpha 1B, kainate 2, serotonin 7, GABA-A), as well as major proteins responsible for their transport and/or anchoring (Homer 1, MAGUK MPP3, Shank2).
Deafness associated changes in expression of two-pore domain potassium channels in the rat cochlear nucleus.
Altschuler et al., Ann Arbor, United States. In Hear Res, 2006
There was a large sustained decrease in the expression of TASK-5, a subunit that is predominantly expressed in auditory brain stem neurons, and in the TASK-1 subunit which is highly expressed in several types of cochlear nucleus neurons.
Silencing of bidirectional promoters by DNA methylation in tumorigenesis.
Issa et al., Houston, United States. In Cancer Res, 2006
From the screen, we selected three bidirectional gene pairs for detailed analysis, WNT9A/CD558500, CTDSPL/BC040563, and KCNK15/BF195580.
Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3.
Daut et al., Marburg an der Lahn, Germany. In J Physiol, 2002
The two-pore-domain potassium channels TASK-1, TASK-3 and TASK-5 possess a conserved C-terminal motif of five amino acids.
Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system.
Karschin et al., Göttingen, Germany. In Mol Cell Neurosci, 2001
hTASK-5 did not functionally express in Xenopus oocytes, whereas chimeric TASK-5/TASK-3 constructs containing the region between M1 and M3 of TASK-3 produced K(+) selective currents.
TASK-5, a novel member of the tandem pore K+ channel family.
Stanfield et al., Leicester, United Kingdom. In Pflugers Arch, 2001
We have named the channel TASK-5 owing to its sequence homology with TASK-1 and TASK-3.
KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1.
Rudy et al., New York City, United States. In J Neurophysiol, 2001
We report the cloning of human KT3.2 and KT3.3 new members of the two-pore K(+) channel (KT) family.
TASK-5, a new member of the tandem-pore K(+) channel family.
Gnatenco et al., North Chicago, United States. In Biochem Biophys Res Commun, 2001
Recently, another member (TASK-5) was identified in the human genome.
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