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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Potassium channel, subfamily K, member 9

TASK-3, KCNK9
an acid-sensing K(+) channel; highly sensitive to changes in extracellular pH [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, TREK-1, K2P, TASK-2, HAD
Papers on TASK-3
A dual phosphorylation switch controls 14-3-3-dependent cell surface expression of TASK-1.
New
Schwappach et al., Göttingen, Germany. In J Cell Sci, Feb 2016
UNASSIGNED: The transport of the potassium channels TASK-1 and TASK-3 to the cell surface is controlled by the binding of 14-3-3 proteins to a trafficking control region at the extreme C-terminus of the channels.
Common variants on 17q25 and gene-gene interactions conferring risk of schizophrenia in Han Chinese population and regulating gene expressions in human brain.
New
Ma et al., Beijing, China. In Mol Psychiatry, Feb 2016
We observed that rs3744165 × rs8073471 interaction modulated the expression profile of TEAD3 (P=1.87 × 10(-8)), SH3TC2 (P=2.00 × 10(-8)), KCNK9 (P=5.20 × 10(-7)) and PPDPF (P=1.13 × 10(-6)) in postmortem cortex tissue; EFNA1 (P=7.26 × 10(-9)), RNU4ATAC (P=2.32 × 10(-8)) and NUPL2 (P=6.79 × 10(-8)) in cerebellum tissue.
pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts.
New
Bentzen et al., Copenhagen, Denmark. In Pflugers Arch, Feb 2016
It has therefore been postulated that K2P3.1 (KCNK3), together with K2P9.1 (KCNK9), could represent novel drug targets for the treatment of atrial fibrillation (AF).
Potassium channels related to primary aldosteronism: Expression similarities and differences between human and rat adrenals.
New
Rainey et al., Ann Arbor, United States. In Mol Cell Endocrinol, Jan 2016
Three potassium channels have been associated with primary aldosteronism (PA) in rodents and humans: KCNK3 (TASK-1), KCNK9 (TASK-3), and KCNJ5 (Kir3.4).
Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat.
New
Bouchard et al., Saint Louis, United States. In Int J Obes (lond), Nov 2015
Genes showing the closest functional links with obesity and inflammation were ADCY8 and KCNK9, respectively.
Role of leak potassium channels in pain signaling.
Review
New
Toyoda et al., China. In Brain Res Bull, Oct 2015
In this review, we describe evidence for the roles of TASK1, TASK3, TREK1, TREK2, TRAAK and TRESK channels in pain signaling and behavior.
TASK channels in arterial chemoreceptors and their role in oxygen and acid sensing.
Review
New
Buckler, Oxford, United Kingdom. In Pflugers Arch, May 2015
The receptor potential is generated by inhibition of Twik-related acid-sensitive K(+) channel 1 and 3 (TASK1/TASK3) heterodimeric channels which normally maintain the cells' resting membrane potential.
The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3.
Review
New
Daut et al., Göttingen, Germany. In Pflugers Arch, May 2015
In the K2P channels, TASK-1 and TASK-3, the influence of protein-protein interactions on sorting decisions has been studied in some detail.
Two-pore domain potassium channels enable action potential generation in the absence of voltage-gated potassium channels.
Review
New
Brickley et al., Boston, United States. In Pflugers Arch, May 2015
Recombinant expression of either TREK-1 or TASK-3 channels was then used to generate a hyperpolarised resting membrane potential (RMP) leading to the characteristic non-linear current-voltage relationship expected of a K2P-mediated conductance.
Two-pore domain potassium channels: potential therapeutic targets for the treatment of pain.
Review
New
Veale et al., Chatham, United Kingdom. In Pflugers Arch, May 2015
Expression of several different K2P channel subunits has been detected in nociceptive dorsal root ganglion neurons and trigeminal ganglion neurons, in particular, TREK1, TREK2, TRESK, TRAAK, TASK3 and TWIK1 channels.
[Neuroprotective effect of progesterone on focal cerebral ischemia/reperfusion injury in rats and its mechanism].
New
Li et al., In Zhongguo Ying Yong Sheng Li Xue Za Zhi, May 2015
After rats were suffered ischemia for 2 h and reperfusion 0, 24, 48, 72 h stress, the nervous functional defect degree were evaluated by longe scoring, and the expression of two-pore domain K channel 3 (TASK3) mRNA in brain tissue were detected by the real-time PCR.
[Construction of acid-sensitive potassium channel-3 eukaryotic expression plasmid and its express in SH-SY5Y cells].
New
Li et al., In Zhongguo Ying Yong Sheng Li Xue Za Zhi, May 2015
OBJECTIVE: To construct the acid-sensitive potassium hannel-3(TASK3) eukaryotic expression plasmid and to establish a stable SH-SY5Y cell line expressing enhanced green fluorescent protein (EGFP)-tagged TASK3.
Study of Five Pubertal Transition-Related Gene Polymorphisms as Risk Factors for Premature Coronary Artery Disease in a Chinese Han Population.
Chen et al., Shanghai, China. In Plos One, 2014
BACKGROUND: Recently, single nucleotide polymorphisms (SNPs) (DLK-rs10144321, SIX6-rs1254337, MKRN3-rs12148769, LIN28B-rs7759938, and KCNK9-rs1469039) were found to be strongly associated with age at menarche.
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Impact
Ong et al., Cambridge, United Kingdom. In Nature, 2014
Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns.
Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
GeneRIF
Commons et al., Boston, United States. In Brain Res, 2012
This study demonistrated that kcnk9 gene expression in mouse dorsal raphe nucleus
TASK-3 channel deletion in mice recapitulates low-renin essential hypertension.
GeneRIF
Barrett et al., Charlottesville, United States. In Hypertension, 2012
TASK3 channel genes may contribute to the development of low renin essential hypertension and idiopathic hyperaldosteronism in mice.
Reduction of breast cancer cell migration via up-regulation of TASK-3 two-pore domain K+ channel.
GeneRIF
Kang et al., Chinju, South Korea. In Acta Physiol (oxf), 2012
an increase in TASK-3 expression levels reduces cell migration/invasion in breast cancer cells
Immunocytochemical localization of TASK-3 channels in rat motor neurons.
GeneRIF
Veh et al., Berlin, Germany. In Cell Mol Neurobiol, 2012
Expression of the TASK-3 protein in motor systems of the rat central nervous system was examined.
Age-related changes in two-pore domain acid-sensitive K⁺ channel expression in rat dorsal root ganglion neurons.
GeneRIF
Kang et al., Chinju, South Korea. In Clin Exp Pharmacol Physiol, 2012
Results suggest that expression of TASK-2 and TASK-3 (but not TASK-1) undergoes age-related changes in dorsal root ganglion (DRG) neurons; TASK-2 and TASK-3 are likely to contribute to resting membrane potential in DRG neurons in neonates and adults.
Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.
Impact
GeneRIF
Powers et al., United States. In Cancer Cell, 2003
Overexpression of KCNK9 in cell lines promotes tumor formation and confers resistance to both hypoxia and serum deprivation.
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