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Potassium channel, subfamily K, member 5

TASK-2, KCNK5
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, TREK-1, TASK-3, K2P, HAD
Papers on TASK-2
Proton detection and breathing regulation by the retrotrapezoid nucleus.
New
Wenker et al., Basel, Switzerland. In J Physiol, Feb 2016
In vitro, their activation by [H(+) ] requires expression of a proton-activated GPCR (GPR4) and a proton-modulated potassium channel (TASK-2) whose transcripts are undetectable in astrocytes and the rest of the lower brainstem respiratory network.
Role of leak potassium channels in pain signaling.
Review
New
Toyoda et al., China. In Brain Res Bull, Oct 2015
Furthermore, we describe the possible involvement of TASK2 and TWIK1 channels in pain.
Neural Control of Breathing and CO2 Homeostasis.
Review
New
Bayliss et al., Charlottesville, United States. In Neuron, Oct 2015
RTN neurons detect CO2 via intrinsic proton receptors (TASK-2, GPR4), synaptic input from peripheral chemoreceptors and signals from astrocytes.
An integrated reweighting theory accounts for the role of task precision in transfer of perceptual learning for similar orientation tasks.
New
Lu et al., In J Vis, Oct 2015
One of the factors influencing the extent of specificity is the difficulty of the training task1 or, alternatively, the precision of the transfer task2.
The two-pore domain K2 P channel TASK2 drives human NK-cell proliferation and cytolytic function.
New
Gross et al., Münster, Germany. In Eur J Immunol, Sep 2015
The current study reveals that in addition to the voltage-gated KV 1.3 and the calcium-activated KCa 3.1 channels, human NK cells also express the two-pore domain K2 P channel TASK2 (TWIK-related acid-sensitive potassium channel).
PHYSIOLOGY. Regulation of breathing by CO₂ requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons.
New
Impact
Bayliss et al., Charlottesville, United States. In Science, Jul 2015
Additional elimination of TASK-2 (K(2P)5), a pH-sensitive K(+) channel expressed in RTN neurons, essentially abolished the ventilatory response to CO2.
9B.02: SOMATIC MUTATIONS IN THE PROMOTER REGION OF THE TWIK-RELATED ACID-SENSITIVE K+ CHANNEL 2 (TASK-2) GENE IN ALDOSTERONE PRODUCING ADENOMAS.
New
Rossi et al., Jackson, United States. In J Hypertens, Jun 2015
OBJECTIVE: We previously showed that a blunted expression of the Twik-related Acid-Sensitive K+ channel 2 (TASK-2) is a common feature of Aldosterone Producing Adenoma (APA).
The CNS under pathophysiologic attack--examining the role of K₂p channels.
Review
New
Bittner et al., Münster, Germany. In Pflugers Arch, May 2015
TASK1 and TREK1 channels have a neuroprotective effect on stroke development, whereas TASK2 channels have a detrimental effect on neuronal survival under ischemic conditions.
The role of pH-sensitive TASK channels in central respiratory chemoreception.
Review
New
Guyenet et al., Charlottesville, United States. In Pflugers Arch, May 2015
Based on expression patterns within several brainstem neuronal cell groups that are believed to function in CO2/H(+) regulation of breathing, three TASK subunits-TASK-1, TASK-2, and TASK-3-were specifically hypothesized to contribute to this central respiratory chemoreflex.
Determining differentially expressed miRNAs and validating miRNA--target relationships using the SPRET/Ei mouse strain.
New
Vandenbroucke et al., Gent, Belgium. In Mamm Genome, Feb 2015
This resulted in the confirmation of six previously unknown miR-target interactions: miR-146a, Zdhhc2; miR-150, Elovl3, Kcnk5, and Nrd1d2; miR-155, Camta1; and miR-592, Steap2.
Pathophysiological significance of the two-pore domain K(+) channel K2P5.1 in splenic CD4(+)CD25(-) T cell subset from a chemically-induced murine inflammatory bowel disease model.
Ohya et al., Kyoto, Japan. In Front Physiol, 2014
The alkaline pH-activated, two-pore domain K(+) channel K2P5.1 (also known as TASK2/KCNK5) plays an important role in maintaining the resting membrane potential, and contributes to the control of Ca(2+) signaling in several types of cells.
Balkan nephropathy.
Review
Polenakovic et al., Скопје, Macedonia. In Clin Nephrol, 2014
Exome sequencing of 22,000 genes revealed that mutant genes (CELA1, HSPG2, and KCNK5) in BN patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, which are tightly connected to the process of angiogenesis.
Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms.
Meuth et al., Münster, Germany. In Int J Mol Sci, 2014
Expression levels of K2P5.1 (TASK2; KCNK5) channels belonging to the family of two-pore domain potassium channels have previously been correlated to the activity of autoreactive T lymphocytes in patients with multiple sclerosis and rheumatoid arthritis.
KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.
Gestreau et al., Marseille, France. In Nat Commun, 2014
A profound deafness associated with a decrease in endocochlear potential is found in adult Kcnk5(-/-) mice.
Relationship of Salivary Alpha Amylase and Cortisol to Social Anxiety in Healthy Children Undergoing Laboratory Pain Tasks.
Zeltzer et al., Los Angeles, United States. In J Child Adolesc Behav, 2013
Saliva samples were collected upon arrival to the laboratory (pre-task), following the completion of the pain tasks (post-task1), and 20 minutes after the completion of the pain tasks (post-task2).
A role for two-pore K⁺ channels in modulating Na⁺ absorption and Cl⁻ secretion in normal human bronchial epithelial cells.
GeneRIF
Kreindler et al., Shanghai, China. In Am J Physiol Lung Cell Mol Physiol, 2012
Potassium channels, in particular K2P channels, are expressed and functional in the apical membrane of airway epithelial cells
Age-related changes in two-pore domain acid-sensitive K⁺ channel expression in rat dorsal root ganglion neurons.
GeneRIF
Kang et al., Chinju, South Korea. In Clin Exp Pharmacol Physiol, 2012
Results suggest that expression of TASK-2 and TASK-3 (but not TASK-1) undergoes age-related changes in dorsal root ganglion (DRG) neurons; TASK-2 and TASK-3 are likely to contribute to resting membrane potential in DRG neurons in neonates and adults.
Volume regulation of murine T lymphocytes relies on voltage-dependent and two-pore domain potassium channels.
GeneRIF
Sukhorukov et al., Münster, Germany. In Biochim Biophys Acta, 2011
Kv1.3/TASK2 channels appear to be mainly responsible for regulatory volume decrease in murine T-lymphocytes.
The two-pore domain potassium channel KCNK5: induction by estrogen receptor alpha and role in proliferation of breast cancer cells.
GeneRIF
Williams et al., Houston, United States. In Mol Endocrinol, 2011
17beta-estradiol induces the expression of KCNK5 via ERalpha(+) in breast cancer cells, and this channel plays a role in regulating proliferation in these cell lines.
Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients.
GeneRIF
Meuth et al., Würzburg, Germany. In Arthritis Res Ther, 2010
Disease activity in rheumatoid arthritis patients correlates strongly with K(2P)5.1 expression levels in CD4+ T lymphocytes in the peripheral blood
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