Proton detection and breathing regulation by the retrotrapezoid nucleus.
Basel, Switzerland. In J Physiol, Feb 2016
In vitro, their activation by [H(+) ] requires expression of a proton-activated GPCR (GPR4) and a proton-modulated potassium channel (TASK-2) whose transcripts are undetectable in astrocytes and the rest of the lower brainstem respiratory network.
Neural Control of Breathing and CO2 Homeostasis.
Charlottesville, United States. In Neuron, Oct 2015
RTN neurons detect CO2 via intrinsic proton receptors (TASK-2, GPR4), synaptic input from peripheral chemoreceptors and signals from astrocytes.
The role of pH-sensitive TASK channels in central respiratory chemoreception.
Charlottesville, United States. In Pflugers Arch, May 2015
Based on expression patterns within several brainstem neuronal cell groups that are believed to function in CO2/H(+) regulation of breathing, three TASK subunits-TASK-1, TASK-2, and TASK-3-were specifically hypothesized to contribute to this central respiratory chemoreflex.
Скопје, Macedonia. In Clin Nephrol, 2014
Exome sequencing of 22,000 genes revealed that mutant genes (CELA1, HSPG2, and KCNK5) in BN patients encode proteins involved in basement membrane/extracellular matrix and vascular tone, which are tightly connected to the process of angiogenesis.