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Taste receptor, type 2, member 50

TAS2R50, hTAS2R50
TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also TAS2R10 (MIM 604791).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: HAD, Palladin, MEN, Ros, ACID
Papers on TAS2R50
Pathway, in silico and tissue-specific expression quantitative analyses of oesophageal squamous cell carcinoma genome-wide association studies data.
Taylor et al., Bethesda, United States. In Int J Epidemiol, Jan 2016
After excluding genes with previous GWAS signals, candidate pathways (and genes) for ESCC risk included taste transduction (KEGG_hsa04742; TAS2R13, TAS2R42, TAS2R14, TAS2R46,TAS2R50), long-patch base excision repair (Reactome_pid; POLD2) and the metabolics pathway (KEGG_hsa01100; MTAP, GAPDH, DCTD, POLD2, AMDHD1).
Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain.
Ferrer et al., Barcelona, Spain. In J Neuropathol Exp Neurol, 2013
Olfactory receptors OR2L13, OR1E1, OR2J3, OR52L1, and OR11H1 and taste receptors TAS2R5 and TAS2R50 were downregulated, but TAS2R10 and TAS2R13 were upregulated at premotor and parkinsonian stages in the frontal cortex area 8 in PD patient brains.
Variations in bitter-taste receptor genes, dietary intake, and colorectal adenoma risk.
Marchand et al., Houston, United States. In Nutr Cancer, 2012
Using a case-control study of 914 colorectal adenoma cases/1188 controls, we explored associations among colorectal adenoma risk, dietary intake, and genetic variation in 3 bitter-taste receptor genes: TAS2R38 (rs713598, rs1726866, rs10246939), TAS2R16 (rs846672), and TAS2R50 (rs1376251).
Genetic analysis of chemosensory traits in human twins.
Reed et al., Philadelphia, United States. In Chem Senses, 2012
New associations were detected for ratings of basil and a bitter taste receptor gene, TAS2R60, and between cilantro and variants in three genes (TRPA1, GNAT3, and TAS2R50).
KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.
Schaefer et al., Boston, United States. In Atherosclerosis, 2012
Assessment of KIF6 genotype is not useful in predicting low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly.
Variations of specific non-candidate genes and risk of myocardial infarction: a replication study.
Kastrati et al., M√ľnchen, Germany. In Int J Cardiol, 2011
The genes encode the cytoskeletal protein palladin (PALLD), a receptor tyrosine kinase (ROS1), a taste receptor (TAS2R50), an olfactory receptor (OR13G1), and a zinc finger protein (ZNF627).
The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.
Meyerhof et al., Potsdam, Germany. In J Agric Food Chem, 2009
TAS2R50 is activated by the natural bitter terpenoids andrographolide and amarogentin.
Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.
Psaty et al., Alameda, United States. In Arterioscler Thromb Vasc Biol, 2008
90%CI 1.02 to 1.41), TAS2R50 (HR=1.13;
Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study.
Intermountain Heart Collaborative Study Group et al., Salt Lake City, United States. In Am Heart J, 2007
Six SNPs were genotyped in the genes palladin, ROS1, TAS2R50, OR13G1, and ZNF627.
Identification of four gene variants associated with myocardial infarction.
Kane et al., Alameda, United States. In Am J Hum Genet, 2005
These gene variants encode the cytoskeletal protein palladin (KIAA0992 [odds ratio (OR) 1.40]), a tyrosine kinase (ROS1 [OR 1.75]), and two G protein-coupled receptors (TAS2R50 [OR 1.58] and OR13G1 [OR 1.40]); all ORs are for carriers of two versus zero risk alleles.
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