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Taste receptor, type 2, member 38

TAS2R38, hTAS2R38
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: AGE, CAN, HAD, ACID, iMpact
Papers on TAS2R38
Differential bitterness in capsaicin, piperine, and ethanol associates with polymorphisms in multiple bitter taste receptor genes.
New
Hayes et al., United States. In Physiol Behav, Feb 2016
Variability in perceived bitterness of capsaicin and ethanol were significantly associated with TAS2R38 and TAS2R3/4/5 diplotypes.
TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis.
New
Cohen et al., Philadelphia, United States. In Int Forum Allergy Rhinol, Jan 2016
The bitter taste receptor T2R38 has recently been demonstrated to regulate upper airway innate defense and may affect patient responses to therapy.
Individual Differences Among Children in Sucrose Detection Thresholds: Relationship With Age, Gender, and Bitter Taste Genotype.
New
Mennella et al., Philadelphia, United States. In Nurs Res, Jan 2016
Five genetic variants of taste genes were assayed: TAS1R3 and GNAT3 (sweet genes; one variant each) and the bitter receptor gene TAS2R38 (three variants).
T2R38 genotype is correlated with sinonasal quality of life in homozygous ΔF508 cystic fibrosis patients.
New
Cohen et al., Philadelphia, United States. In Int Forum Allergy Rhinol, Jan 2016
T2R38 is a bitter taste receptor expressed in the sinonasal tract, and nonfunctional alleles of this receptor have been implicated in treatment-refractory CRS in non-CF patients.
Drivers of chronic rhinosinusitis: Inflammation versus infection.
Review
New
Hamilos, Boston, United States. In J Allergy Clin Immunol, Dec 2015
Certain deficiencies in local innate immunity have been described in patients with CRS that predispose to increased sinus mucosal bacterial colonization/infection, including deficient local production of antimicrobial lactoferrin and deficient functioning of the bitter taste receptor TAS2R38.
A potential trigger for pine mouth: a case of a homozygous phenylthiocarbamide taster.
New
Drayna et al., Bologna, Italy. In Nutr Res, Dec 2015
TAS2R38 genotyping demonstrated that this subject was a homozygous carrier of the proline-alanine-valine taster haplotype.
Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception.
New
Meyerhof et al., Potsdam, Germany. In Plos Genet, Sep 2015
Nonetheless, bitter perception is subject to individual variations due to the presence of genetic functional polymorphisms in bitter taste receptor (TAS2R) genes, such as the long-known association between genetic polymorphisms in TAS2R38 and bitter taste perception of phenylthiocarbamide.
Genomic Study of Cardiovascular Continuum Comorbidity.
New
Puzyrev et al., Tomsk, Russia. In Acta Naturae, Jul 2015
A total of 14 genetic variants were associated with a combination of several diseases of cardiovascular continuum (CVC), including those in the TAS2R38, SEZ6L, APOA2, KLF7, CETP, ITGA4, RAD54B, LDLR, and MTAP genes, along with intragenic variants rs1333048, rs1333049, and rs6501455.
Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis.
Review
New
Cohen et al., Philadelphia, United States. In Curr Opin Allergy Clin Immunol, Feb 2015
Clinical studies have also found correlations of TAS2R38 genotype with susceptibility to gram-negative upper respiratory infection and established T2R38 as an independent risk factor for chronic rhinosinusitis requiring sinus surgery.
Rare haplotypes of the gene TAS2R38 confer bitter taste sensitivity in humans.
Garneau et al., Denver, United States. In Springerplus, 2014
BACKGROUND: The TAS2R38 gene is widely responsible for the well-known bimodal response to a family of bitter chemicals which includes 6-n-propylthiouracial (PROP).
Amarogentin Displays Immunomodulatory Effects in Human Mast Cells and Keratinocytes.
Schempp et al., Freiburg, Germany. In Mediators Inflamm, 2014
Keratinocytes express the bitter taste receptors TAS2R1 and TAS2R38.
Genetic sensitivity to the bitter taste of 6-n-propylthiouracil (PROP) and its association with physiological mechanisms controlling body mass index (BMI).
Review
Tomassini Barbarossa et al., New Brunswick, United States. In Nutrients, 2014
This review describes genetic factors that may contribute to PROP sensitivity including: (1) the variants of the TAS2R38 bitter receptor with their different affinities for the stimulus; (2) the gene that controls the gustin protein that acts as a salivary trophic factor for fungiform taste papillae; and (3) other specific salivary proteins that could be involved in facilitating the binding of the PROP molecule with its receptor.
Pharmacogenetics of taste: turning bitter pills sweet?
Review
Guchelaar et al., Utrecht, Netherlands. In Pharmacogenomics, 2014
Recent studies showed that interindividual differences in PROP sensitivity can be largely explained by three SNPs in TAS2R38, encoding a bitter taste receptor.
The emerging role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis.
Review
Cohen et al., Philadelphia, United States. In Am J Rhinol Allergy, 2013
T2R38 is encoded by the TAS2R38 gene, which has several common genetic polymorphisms that result in altered receptor functionality.
Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa.
GeneRIF
Tishkoff et al., United States. In Mol Biol Evol, 2012
Report striking patterns of variation at TAS2R38, including a significant excess of novel rare nonsynonymous polymorphisms that recently arose only in Africa, high frequencies of haplotypes in Africa associated with intermediate bitter taste sensitivity.
Implication of the G145C polymorphism (rs713598) of the TAS2r38 gene on food consumption by Brazilian older women.
GeneRIF
Nobrega et al., Brasília, Brazil. In Arch Gerontol Geriatr, 2012
G145C polymorphism (rs713598) related to taste and food preferences and habits
Relationship between bitter-taste receptor genotype and solid medication formulation usage among young children: a retrospective analysis.
GeneRIF
Mennella et al., Philadelphia, United States. In Clin Ther, 2012
Children with >/=1 bitter-sensitive allele (TAS2R38 PP or AP genotype) were more likely to have taken medication in solid formulation than were bitter-insensitive (AA genotype) children.
Polymorphisms in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype.
GeneRIF
Barbarossa et al., Monserrato, Italy. In Physiol Behav, 2011
The data of this study showed how the combination of the TAS2R38 and gustin gene genotypes modulate PROP phenotype.
TAS2R38 bitter taste genetics, dietary vitamin C, and both natural and synthetic dietary folic acid predict folate status, a key micronutrient in the pathoaetiology of adenomatous polyps.
GeneRIF
Veysey et al., Newcastle, Australia. In Food Funct, 2011
study examined bitter taste genetics and whether variation in the TAS2R38 gene at three polymorphic loci (A49P, V262A and I296V) could alter dietary and systemic folate levels and dietary vitamin C intake
Independent evolution of bitter-taste sensitivity in humans and chimpanzees.
Impact
Bamshad et al., Salt Lake City, United States. In Nature, 2006
In humans, variable PTC sensitivity is largely controlled by the segregation of two common alleles at the TAS2R38 locus, which encode receptor variants with different ligand affinities.
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