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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TRIO and F-actin binding protein

This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008] (from NCBI)
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Top mentioned proteins: Actin, CAN, V1a, HAD, SET
Papers on Tara
Identification of a nonsense mutation in the STRC gene in a Korean family with moderate hearing loss.
Kim et al., Taegu, South Korea. In Int J Pediatr Otorhinolaryngol, Jan 2016
Implementing a bioinformatic platform for filtering and detecting variations allowed for the identification of two variations within different genes (c.650G>A in TRIOBP and c.4057C>T in STRC).
The symbiotic life of Symbiodinium in the open ocean within a new species of calcifying ciliate (Tiarina sp.).
Decelle et al., Paris, France. In Isme J, Jan 2016
Ecological analyses using the Tara Oceans metabarcoding data set (V9 region of the 18S rDNA) and contextual oceanographic parameters showed a global distribution of the symbiotic partnership in nutrient-poor surface waters.
Reverse transcriptase genes are highly abundant and transcriptionally active in marine plankton assemblages.
Ogata et al., Marseille, France. In Isme J, Dec 2015
We investigated the abundance, classification and transcriptional status of RTs based on Tara Oceans marine metagenomes and metatranscriptomes encompassing a wide organism size range.
Lipid remodelling is a widespread strategy in marine heterotrophic bacteria upon phosphorus deficiency.
Chen et al., Barcelona, Spain. In Isme J, Dec 2015
Analyses of the Global Ocean Sampling and Tara Oceans metagenome data sets demonstrate that PlcP is particularly abundant in areas characterized by low phosphate concentrations.
TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila.
Koh et al., Philadelphia, United States. In Curr Biol, Jul 2015
Here, we identify TARANIS (TARA), a Drosophila homolog of the Trip-Br (SERTAD) family of transcriptional coregulators, as a molecule that is required for normal sleep patterns.
Ocean plankton. Structure and function of the global ocean microbiome.
Bork et al., Heidelberg, Germany. In Science, Jun 2015
We analyzed 7.2 terabases of metagenomic data from 243 Tara Oceans samples from 68 locations in epipelagic and mesopelagic waters across the globe to generate an ocean microbial reference gene catalog with >40 million nonredundant, mostly novel sequences from viruses, prokaryotes, and picoeukaryotes.
Ocean plankton. Patterns and ecological drivers of ocean viral communities.
Sullivan et al., Tucson, United States. In Science, Jun 2015
Here, we use quantitative double-stranded DNA (dsDNA) viral-fraction metagenomes (viromes) and whole viral community morphological data sets from 43 Tara Oceans expedition samples to assess viral community patterns and structure in the upper ocean.
Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology.
Hammond et al., Rotterdam, Netherlands. In Genet Epidemiol, Mar 2015
We identified 10 new loci associated with disc area (CDC42BPA, F5, DIRC3, RARB, ABI3BP, DCAF4L2, ELP4, TMTC2, NR2F2, and HORMAD2) and another 10 new loci associated with cup area (DHRS3, TRIB2, EFEMP1, FLNB, FAM101, DDHD1, ASB7, KPNB1, BCAS3, and TRIOBP).
Expanding the World of Marine Bacterial and Archaeal Clades.
Glöckner et al., Bremen, Germany. In Front Microbiol, 2014
The importance of these questions is underlined by concerted, large-scale, and global ocean sampling initiatives, for example the International Census of Marine Microbes, Ocean Sampling Day, or Tara Oceans.
Modeling a microbial community and biodiversity assay with OBO Foundry ontologies: the interoperability gains of a modular approach.
Gonzalez-Beltran et al., Philadelphia, United States. In Database (oxford), 2014
Projects such as Tara Oceans, Moorea Biocode Project and Gut Microbiome rely on sequencing technologies to probe community diversity.
Evolutionary history of Chaetognatha inferred from molecular and morphological data: a case study for body plan simplification.
Perez et al., Marseille, France. In Front Zool, 2013
This work includes 36 extant species, mainly obtained from Tara Oceans Expedition 2009/2012, that represent 16 genera and 6 of the 9 extant families.
Aggregation of the protein TRIOBP-1 and its potential relevance to schizophrenia.
Korth et al., Düsseldorf, Germany. In Plos One, 2013
Pursuing this epitope discovery paradigm further, we reveal TRIO binding protein (TRIOBP) to be a major substrate of a monoclonal antibody with a high specificity to brain aggregomes from patients with chronic mental illness.
Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling.
Tsukita et al., Suita, Japan. In J Cell Biol, 2011
Tara activates Rac1 through the Trio RhoGEF, which binds to E-cadherin and subsequently increases the phosphorylation of p38 and Tbx3, a transcriptional E-cadherin repressor.
Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing.
Friedman et al., Rockville, United States. In Cell, 2010
mutant Triobp mice are profoundly deaf; stereocilia of Triobp mice develop normally but fail to form rootlets and are easier to deflect and damage.
Wrapping up stereocilia rootlets.
Petit et al., Paris, France. In Cell, 2010
Kitajiri et al. (2010) now show that the actin-binding protein TRIOBP tightly bundles the actin filaments into rootlets, endowing these stereocilia "pivots" with unique elasticity and robustness.
Antimitotic effect of the retinoid 4-oxo-fenretinide through inhibition of tubulin polymerization: a novel mechanism of retinoid growth-inhibitory activity.
Formelli et al., Milano, Italy. In Mol Cancer Ther, 2009
Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp.
The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara.
Huang et al., Hangzhou, China. In Biochem Biophys Res Commun, 2008
All these findings suggest that HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara.
Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss.
Kanaan et al., Bethlehem, South Africa. In Am J Hum Genet, 2006
Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss.
Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial.
Sattar et al., Glasgow, United Kingdom. In Lancet, 2004
BACKGROUND: Rheumatoid arthritis is characterised by inflammatory synovitis, articular destruction, and accelerated atherogenesis.
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