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TAR RNA-binding protein, TRP-185
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NRC, Dicer, PKR, RISC, CAN
Papers on TAR RNA-binding protein
Recombinant hTRBP and hPACT Modulate hAgo2-Catalyzed siRNA-Mediated Target RNA Cleavage In Vitro.
Restle et al., Regensburg, Germany. In Plos One, Dec 2015
The human TAR RNA-binding protein (hTRBP) and protein activator of protein kinase R (hPACT) are important players in RNA interference (RNAi).
Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner.
Bhatnagar et al., New Delhi, India. In Biochem J, Nov 2015
Also, the interaction of dvNS3 with hHSC70 perturbs the formation of RISC (RNA-induced silencing complex)-loading complex (RLC), by displacing TRBP (TAR RNA-binding protein) and possibly impairing the downstream activity of miRNAs.
Morphine Promotes Astrocyte-Preferential Differentiation of Mouse Hippocampal Progenitor Cells via PKCε-Dependent ERK Activation and TRBP Phosphorylation.
Law et al., Minneapolis, United States. In Stem Cells, Sep 2015
Conversely, after morphine treatment, phospho-ERK remains in the cytosol and is capable of phosphorylating TAR RNA-binding protein (TRBP), a cofactor of Dicer.
Dissecting the roles of TRBP and PACT in double-stranded RNA recognition and processing of noncoding RNAs.
Plevin et al., York, United Kingdom. In Wiley Interdiscip Rev Rna, May 2015
HIV TAR RNA-binding protein (TRBP) and Protein Activator of PKR (PACT) are double-stranded (ds) RNA-binding proteins that participate in both small regulatory RNA biogenesis and the response to viral dsRNA.
A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity.
Hotamisligil et al., Boston, United States. In Cell Rep, May 2015
Here, we report the formation of a complex between PKR and TAR RNA-binding protein (TRBP) during metabolic and obesity-induced stress, which is critical for the regulation of eukaryotic translation initiation factor 2 alpha (eIF2α) phosphorylation and c-Jun N-terminal kinase (JNK) activation.
Double-stranded RNA in the biological control of grain aphid (Sitobion avenae F.).
Xia et al., Beijing, China. In Funct Integr Genomics, Mar 2015
Functional annotation of these unigenes revealed not only the presence of genes that encode the key components of RNAi machinery such as Dicer and Argonaute but also the genes encoding the TAR RNA binding protein (TRBP) and the SID-1 protein, which function in assisting the RNA-induced silencing complex (RISC) formation in microRNA (miRNA) pathway and mediating a systemic RNA interference (RNAi) effect though a cellular uptake mechanism.
Regulatory networks between neurotrophins and miRNAs in brain diseases and cancers.
Shi, San Francisco, United States. In Acta Pharmacol Sin, Feb 2015
The results of BNDF research show that neurotrophins regulate miRNAs in at least three ways: (1) ERK stimulation enhances the activation of TRBP (HIV-1 TAR RNA-binding protein) and Dicer, leading to the upregulation of miRNA biogenesis; (2) ERK-dependent upregulation of Lin28a (RNA-binding proteins) blocks select miRNA biogenesis; (3) transcriptional regulation of miRNA expression through activation of transcription factors, including CREB and NF-κB.
Helical defects in microRNA influence protein binding by TAR RNA binding protein.
Showalter et al., United States. In Plos One, 2014
BACKGROUND: MicroRNAs (miRNAs) are critical post-transcriptional regulators of gene expression.
Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex.
Lu et al., New Orleans, United States. In Oncogene, 2014
Immunoprecipitation revealed that RPL5 binds to 3'UTR of c-Myc mRNA and two subunits of RISC, TRBP (HIV-1 TAR RNA-binding protein) and Ago2, mediating the targeting of c-Myc mRNA by miRNAs.
dsRNA binding protein PACT/RAX in gene silencing, development and diseases.
Ke et al., Shanghai, China. In Front Biol, 2014
Besides the role of activating PKR, PACT is associated with a ~500 kDa complex that contains Dicer, hAgo2, and TRBP (TAR RNA binding protein) and it associates with Dicer to facilitate the production of small interfering RNA.
The multiple functions of TRBP, at the hub of cell responses to viruses, stress, and cancer.
Gatignol et al., Montréal, Canada. In Microbiol Mol Biol Rev, 2012
The TAR RNA binding protein (TRBP) has emerged as a key player in many cellular processes.
Multiple levels of PKR inhibition during HIV-1 replication.
Gatignol et al., Montréal, Canada. In Rev Med Virol, 2011
In addition, HIV-1 replicates only in cells that have a high level of the TAR RNA binding protein (TRBP), a strong inhibitor of PKR activation.
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function.
Esteller et al., Madrid, Spain. In Nat Genet, 2009
Here we have identified truncating mutations in TARBP2 (TAR RNA-binding protein 2), encoding an integral component of a DICER1-containing complex, in sporadic and hereditary carcinomas with microsatellite instability.
Characterization of the TRBP domain required for dicer interaction and function in RNA interference.
Gatignol et al., Montréal, Canada. In Bmc Mol Biol, 2008
Binding of Dicer to TRBPs is critical for RNAi function.
Protein components of the microRNA pathway and human diseases.
Provost et al., Québec, Canada. In Methods Mol Biol, 2008
However, the accessory proteins of the miRNA pathway, such as the DiGeorge syndrome critical region gene 8 (DGCR8) protein, Exportin-5 (Exp-5), TAR RNA binding protein (TRBP) and fragile X mental retardation protein (FMRP), are each related, in various ways, to specific genetic diseases.
Crystal structure of the methyltransferase domain of human TARBP1.
Plotnikov et al., Toronto, Canada. In Proteins, 2008
The crystal structure of methyltransferase domain of human TARBP1 protein in complex with S-adenosyl-L-homocysteine (AdoHcy) at 1.6-A resolution, is reported.
Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1.
Jeang et al., Bethesda, United States. In J Biol Chem, 2003
induces induction of HIV-1 long terminal repeat by human and murine cyclin T1 and requires Sp1.
Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR.
Jeang et al., Bethesda, United States. In Science, 1991
A HeLa complementary DNA was isolated and characterized that encodes a TAR RNA-binding protein (TRBP).
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