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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transporter 1, ATP-binding cassette, sub-family B

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: C-1, MHC, CAN, HAD, TACE
Papers using TAP1 antibodies
Lipid rafts, detergent-resistant membranes, and raft targeting signals
Hueber A-O et al., In Cell Death & Disease, 2005
... The matrix metalloprotease inhibitor TAPI-2 (N-(R)-(2-(hydroxyamino-arbonyl)methyl)-4-methylpenthanoyl--t-butyl-alanyl--alanine, 2-aminoethyl amide) was purchased from Merck (Nottingham, UK) ...
Differentiated structure and function of cultures from human tracheal epithelium.
Rich Benjamin, In PLoS ONE, 1991
... MMPs and TACE inhibitor (TAPI-1) was purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on TAP1
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.
van Hall et al., In J Clin Invest, Feb 2016
Deficiency in processing components, like the transporter associated with antigen processing (TAP), results in strongly decreased surface display of peptide/MHC-I complexes.
A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling.
Ellis et al., Houston, United States. In Stem Cells Transl Med, Feb 2016
We treated established CRC cell lines and a newly established human CRC cell line HCP-1 with ADAM17-specific small interfering RNA (siRNA) or the synthetic peptide inhibitor TAPI-2.
Interferon Alpha Signalling and Its Relevance for the Upregulatory Effect of Transporter Proteins Associated with Antigen Processing (TAP) in Patients with Malignant Melanoma.
Baron et al., Aachen, Germany. In Plos One, Dec 2015
The transporter protein associated with antigen processing-1 (TAP1) is part of the MHC class I peptide-loading complex, and important for antigen presentation in tumor and antigen presenting cells.
Polymorphisms of Transporter Associated with Antigen Presentation, Tumor Necrosis Factor-α and Interleukin-10 and their Implications for Protection and Susceptibility to Severe Forms of Dengue Fever in Patients in Sri Lanka.
De Silva et al., Colombo, Sri Lanka. In J Glob Infect Dis, Oct 2015
SETTINGS AND DESIGN: Polymorphism studies are carried out on genes for; transporter associated with antigen presentation (TAP), promoter of tumor necrosis factor-α (TNF-α), and promoter of interleukin-10 (IL-10).
The transporter associated with antigen processing: a key player in adaptive immunity.
Tampé et al., In Biol Chem, Sep 2015
Antigenic peptides are primarily generated by proteasomal degradation and translocated into the lumen of the endoplasmic reticulum (ER) by the transporter associated with antigen processing (TAP).
What chickens would tell you about the evolution of antigen processing and presentation.
Kaufman, Cambridge, United Kingdom. In Curr Opin Immunol, Jun 2015
The chicken MHC is organized differently than mammals, allowing the co-evolution of polymorphic genes, with each MHC haplotype having a set of TAP1, TAP2 and tapasin alleles directed to high expression of a single classical class I molecule.
ABC transporters in adaptive immunity.
Tampé et al., Frankfurt am Main, Germany. In Biochim Biophys Acta, Mar 2015
SCOPE OF REVIEW: The heterodimeric transporter associated with antigen processing TAP1/2 (ABCB2/3) is a crucial element of the adaptive immune system.
Association between TAP1 gene polymorphisms and alopecia areata in a Korean population.
Kim et al., Ch'ŏnan, South Korea. In Genet Mol Res, 2014
The transporter 1 ATP-binding cassette sub-family B (MDR/TAP) gene (TAP1) is located in the major histocompatibility complex class II region, and forms a heterodimer that plays a key role in endogenous antigen presentation pathways.
TAP expression level in tumor cells defines the nature and processing of MHC class I peptides for recognition by tumor-specific cytotoxic T lymphocytes.
Mami-Chouaib et al., Lebanon. In Ann N Y Acad Sci, 2013
The ppCT peptide is derived from the C-terminal region of the signal peptide and is processed independently of proteasomes and the transporter associated with antigen processing (TAP)1/TAP2 heterodimeric complexes.
Purification, crystallization and preliminary X-ray crystallographic analysis of the ATPase domain of human TAP in nucleotide-free and ADP-, vanadate- and azide-complexed forms.
Saxena et al., United States. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
X-ray diffraction data sets were collected for apo and complexed ATPase domain of human TAP1 using an in-house X-ray diffraction facility at a wavelength of 1.5418 A
Expression of antigen processing and presenting molecules in brain metastasis of breast cancer.
Okada et al., Pittsburgh, United States. In Cancer Immunol Immunother, 2012
The data suggest that patients with low or defective TAP1 or calnexin in primary breast cancers may be at higher risks for developing brain metastasis due to the defects in T cell-based immunosurveillance.
NLRC5: a newly discovered MHC class I transactivator (CITA).
Kobayashi et al., Boston, United States. In Microbes Infect, 2012
In addition to MHC class I genes, NLRC5 can induce the expression of β2M, TAP1 and LMP2, essential components of MHC class I antigen presentation.
Role of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (HLA)-B7 class I antigen presentation.
López et al., Madrid, Spain. In J Biol Chem, 2012
Role of metalloproteases in vaccinia virus epitope processing for transporter associated with antigen processing (TAP)-independent human leukocyte antigen (HLA)-B7 class I antigen presentation.
Multiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cells.
López et al., Madrid, Spain. In J Virol, 2012
Six vaccinia virus ligands were presented by HLA-B51 and/or HLA-Cw1 class I molecules in human TAP-deficient cells.
TAP1-deficiency does not alter atherosclerosis development in Apoe-/- mice.
Fredrikson et al., Malmö, Sweden. In Plos One, 2011
Apoe(-/-)Tap1(-/-) mice develop atherosclerosis equal to Apoe(-/-) mice, indicating a minor role for CD8(+) T cells and TAP1-dependent antigen presentation in the disease process.
A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells.
Guermonprez et al., Paris, France. In Immunity, 2009
Current models involve cytosolic proteolysis of antigens by the proteasome and peptide import into endoplasmic reticulum (ER) or phagosomal lumen by the transporters associated with antigen processing (TAP1 and TAP2).
Viral degradation of the MHC class I peptide loading complex.
Stevenson et al., Cambridge, United Kingdom. In Immunity, 2004
Here we show that MK3 also provides the first example of a protein that degrades tapasin and TAP.
The transporter associated with antigen processing: function and implications in human diseases.
Tampé et al., Marburg an der Lahn, Germany. In Physiol Rev, 2002
The delivery of these peptides is performed by the transporter associated with antigen processing (TAP).
TAP expression provides a general method for improving the recognition of malignant cells in vivo.
Jefferies et al., Vancouver, Canada. In Nat Biotechnol, 2000
To test the potential of providing exogenous TAP in cancer therapies, we constructed a vaccinia virus (VV) containing the TAP1 gene and examined whether VV-TAP1 could reduce tumors in mice.
Lateral diffusion of GFP-tagged H2Ld molecules and of GFP-TAP1 reports on the assembly and retention of these molecules in the endoplasmic reticulum.
Edidin et al., Baltimore, United States. In Immunity, 1999
H2Ld molecules, associated with the TAP complex, diffuse slowly, as does GFP-tagged TAP1.
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