Grp1 plays a key role in linking insulin signaling to glut4 recycling.
Boston, United States. In Dev Cell, 2012
A major mechanism by which insulin regulates glut4 recycling was uncovered. A general receptor for 3-phosphoinositides 1 was identified as a guanine nucleotide exchange factor for ADP-ribosylation factor 6 that promotes glut4 vesicle formation.