GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 05 Jun 2013.
GRP1
tamalin, GRP1-associated scaffold protein
scaffold protein; promotes intracellular trafficking and cell surface expression of group 1 metabotropic glutamate receptors [RGD, Feb 2006] (from
NCBI)
Papers on
tamalin
Support for the N -Methyl-D-Aspartate Receptor Hypofunction Hypothesis of Schizophrenia From Exome Sequencing in Multiplex Families.
New
In Jama Psychiatry, 03 May 2013
One pedigree shared a missense and frameshift substitution of GRM5, encoding the metabotropic glutamate receptor subtype 5 (mGluR5), which is coupled to the NMDA receptor and potentiates its signaling; the frameshift disrupts binding to the scaffolding protein tamalin and increases mGluR5 internalization.
Tamalin is a critical mediator of electroconvulsive shock-induced adult neuroplasticity.
New
Frederick, United States. In J Neurosci, Mar 2012
Here we show a dynamic upregulation of the scaffold protein tamalin, selectively in the hippocampus of animals subjected to ECS.
GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180.
GeneRIF
United States. In Mol Biol Cell, 2010
protein-protein interaction mediated by ARNO coiled-coil domain required for ARNO induced motility; coiled-coil domain promotes assembly of multiprotein complex containing ARNO and Dock180; assembly of complex requires coiled-coil domain, GRASP and IPCEF
[Metabotropic glutamate receptor trafficking mechanism--autoinhibitory role of a scaffold protein tamalin].
GeneRIF
Nagoya, Japan. In Seikagaku, 2008
plays a role in metabotropic glutamate receptor transport and forms its autoinhibitory state.[review]
Altered sensitivities to morphine and cocaine in scaffold protein tamalin knockout mice.
Suita, Japan. In Proc Natl Acad Sci U S A, 2007
Tamalin is a scaffold protein that interacts with metabotropic glutamate receptors and the kinase-deficient neurotrophin TrkCT1 receptor and forms a protein complex with multiple protein-trafficking and intracellular signaling molecules.
Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation.
GeneRIF
Suita, Japan. In Embo J, 2007
The crystal structures of the autoinhibitory PDZ domain of Tamalin has implications for the regulation of metabotropic glutamate receptor trafficking.
A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin.
Frederick, United States. In J Cell Biol, 2006
We show that the neurotrophin-3 (NT3) TrkCT1-truncated receptor binds to the scaffold protein tamalin in a ligand-dependent manner.
Phosphorylation and recruitment of Syk by immunoreceptor tyrosine-based activation motif-based phosphorylation of tamalin.
GeneRIF
Kyoto, Japan. In J Biol Chem, 2004
tamalin is a novel signaling molecule that possesses a PDZ domain and a PDZ binding motif and mediates Syk signaling in an ITAM-based fashion
Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction.
Kyoto, Japan. In Genes Cells, 2004
In this investigation, we report that HCN2 forms a protein assembly with tamalin, S-SCAM and Mint2 scaffold proteins, using several different approaches including immunoprecipitation of rat brain and heterologously expressing cell extracts and glutathione S-transferase pull-down assays.
Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association.
GeneRIF
Kyoto, Japan. In J Biol Chem, 2003
Tamalin interacts with multiple neuronal proteins and several scaffold proteins in the brain through its distinct evolutionarily-conserved protein-binding domains; and tamalin mRNA is developmentally up-regulated at the postnatal period.
Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins.
Kyoto, Japan. In J Neurosci, 2002
In this investigation, we report identification and characterization of a 95 kDa postsynaptic density protein (PSD-95)/discs-large/ZO-1 (PDZ) domain-containing protein termed tamalin, also recently named GRP1-associated scaffold protein (GRASP), that interacts with group 1 metabotropic glutamate receptors (mGluRs).
Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors.
Corvallis, United States. In J Biol Chem, 2000
A novel, retinoic acid-induced gene, GRP1-associated scaffold protein (GRASP), was isolated from P19 embryonal carcinoma cells using a subtractive screening strategy.
