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Potassium channel, subfamily K, member 17

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: TASK-2, ACID, HAD, TALK-1, TASK-3
Papers on TALK-2
Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells.
Kletsas et al., Athens, Greece. In J Cell Physiol, Dec 2015
A 5- and a 24-h hyperosmotic treatment led to the differential expression of >100 and >200 genes, respectively, including nine genes encoding transporters (SLC4A11, SLC5A3, ATP1A1, SLC38A2, KCNK17, KCTD20, KCTD11, SLC7A5, and CLCA2).
Inherited progressive cardiac conduction disorders.
Abriel et al., Bern, Switzerland. In Curr Opin Cardiol, 2015
RECENT FINDINGS: Inherited PCCD in structurally normal hearts has been found to be linked to genetic variants in the ion channel genes SCN5A, SCN1B, SCN10A, TRPM4, and KCNK17, as well as in genes coding for cardiac connexin proteins.
Association of variants in KCNK17 gene with ischemic stroke and cerebral hemorrhage in a Chinese population.
Wang et al., Shantou, China. In J Stroke Cerebrovasc Dis, 2014
BACKGROUND: KCNK17 (potassium channel, subfamily K, member17) has a role in the pathogenesis of stroke.
Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder.
Decher et al., Münster, Germany. In Embo Mol Med, 2014
Due to the severe phenotype, we performed whole-exome sequencing (WES) and identified an additional mutation in the KCNK17 gene encoding the K2P potassium channel TASK-4.
Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure.
Chen et al., Taipei, Taiwan. In Environ Res, 2014
Significant associations between cumulative arsenic exposure and DNA methylation levels of 28 patients were observed in nine CpG sites of nine gens including PDGFD (Spearman rank correlation, 0.54), CTNNA2 (0.48), KCNK17 (0.52), PCDHB2 (0.57), ZNF132 (0.48), DCDC2 (0.48), KLK7 (0.48), FBXO39 (0.49), and NPY2R (0.45).
The rs10947803 SNP of KCNK17 is associated with cerebral hemorrhage but not ischemic stroke in a Chinese population.
Wang et al., Beijing, China. In Neurosci Lett, 2013
KCNK17 (potassium channel, subfamily K, member17) was first discovered to associate with the pathogenesis of ischemic stroke in the first genome-wide association study.
Gating of a pH-sensitive K(2P) potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter.
Niemeyer et al., Valdivia, Chile. In Plos One, 2010
Leak K(2P) K(+) channels TASK-2, TALK-1 and TALK-2 are gated open by extracellular alkalinization.
GLO1-A novel amplified gene in human cancer.
Stratton et al., Cambridge, United Kingdom. In Genes Chromosomes Cancer, 2010
A previously uncharacterized amplicon located on 6p21.2 whose 1 Mb minimal common amplified region contained eight genes (GLO1, DNAH8, GLP1R, C6orf64, KCNK5, KCNK17, KCNK16, and C6orf102) was further investigated to determine which gene(s) are the biological targets of this amplicon.
Identification of common variants within KCNK17 in Chinese Han population.
Xu et al., Wuhan, China. In J Huazhong Univ Sci Technolog Med Sci, 2010
KCNK17 is a member of the acid-sensitive subfamily of tandem pore K(+) channels, which are open at all membrane potentials an red contribute to cellular resting membrane potential.
KCNK17 genetic variants in ischemic stroke.
Montaner et al., Barcelona, Spain. In Atherosclerosis, 2010
The A allele of the rs10947803 variant of KCNK17 was associated with increased risk of IS and increased levels of KCNK17 gene expression.
Recurrent copy number changes in mentally retarded children harbour genes involved in cellular localization and the glutamate receptor complex.
Hochstenbach et al., Utrecht, Netherlands. In Eur J Hum Genet, 2010
CNCs occurring specifically in our study cohort were enriched for components of the glutamate receptor family (GRIA2, GRIA4, GRIK2 and GRIK4) and genes encoding proteins involved in guiding cell localization during development (ATP1A2, GIRK3, GRIA2, KCNJ3, KCNJ10, KCNK17 and KCNK5).
Alterations in gene expression in the caput epididymides of nonobstructive azoospermic men.
Cyr et al., Québec, Canada. In Biol Reprod, 2008
Differentially regulated genes included several encoding proteins involved in spermatozoal maturation, water and ion channels, and beta-defensins: CRISP1, SPINLW1, FAM12B, and DEFB129 were upregulated, whereas CFTR, AQP5, KCNK4, KCNK17, SLC6A20, SLC13A3, DEFB126, and DEFB106A were downregulated.
Health interventions with girls in the juvenile justice system.
Martinez et al., Kansas City, United States. In Womens Health Issues, 2007
To address the interrelated sexual and dating violence risk behaviors of this population, we compared the relative impact of a 6-hour, peer-led group intervention, Girl Talk-2, whose goal was to decrease sexual and dating violence risk behaviors, with the impact of a comparison group in which the same information was presented in a standard lecture and video format.
A Ba2+-resistant, acid-sensitive K+ conductance in Na+-absorbing H441 human airway epithelial cells.
Wilson et al., Dundee, United Kingdom. In Am J Physiol Lung Cell Mol Physiol, 2007
Analyses using RT-PCR showed that mRNA encoding several two-pore domain K(+) (K2P) channels was detected in cells grown under standard conditions (TWIK-1, TREK-1, TASK-2, TWIK-2, KCNK-7, TASK-3, TREK-2, THIK-1, and TALK-2).
Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel.
Sepúlveda et al., Valdivia, Chile. In Proc Natl Acad Sci U S A, 2007
TASK-2, TALK-1, and TALK-2 are two-pore region (2P) KCNK K+ channels gated open by extracellular alkalinization.
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