Deficiency in the α1 subunit of Na+/K+-ATPase enhances the anti-proliferative effect of high osmolality in nucleus pulposus intervertebral disc cells.
Athens, Greece. In J Cell Physiol, Dec 2015
A 5- and a 24-h hyperosmotic treatment led to the differential expression of >100 and >200 genes, respectively, including nine genes encoding transporters (SLC4A11, SLC5A3, ATP1A1, SLC38A2, KCNK17, KCTD20, KCTD11, SLC7A5, and CLCA2).
Inherited progressive cardiac conduction disorders.
Bern, Switzerland. In Curr Opin Cardiol, 2015
RECENT FINDINGS: Inherited PCCD in structurally normal hearts has been found to be linked to genetic variants in the ion channel genes SCN5A, SCN1B, SCN10A, TRPM4, and KCNK17, as well as in genes coding for cardiac connexin proteins.
Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure.
Taipei, Taiwan. In Environ Res, 2014
Significant associations between cumulative arsenic exposure and DNA methylation levels of 28 patients were observed in nine CpG sites of nine gens including PDGFD (Spearman rank correlation, 0.54), CTNNA2 (0.48), KCNK17 (0.52), PCDHB2 (0.57), ZNF132 (0.48), DCDC2 (0.48), KLK7 (0.48), FBXO39 (0.49), and NPY2R (0.45).
GLO1-A novel amplified gene in human cancer.
Cambridge, United Kingdom. In Genes Chromosomes Cancer, 2010
A previously uncharacterized amplicon located on 6p21.2 whose 1 Mb minimal common amplified region contained eight genes (GLO1, DNAH8, GLP1R, C6orf64, KCNK5, KCNK17, KCNK16, and C6orf102) was further investigated to determine which gene(s) are the biological targets of this amplicon.
KCNK17 genetic variants in ischemic stroke.
Barcelona, Spain. In Atherosclerosis, 2010
The A allele of the rs10947803 variant of KCNK17 was associated with increased risk of IS and increased levels of KCNK17 gene expression.
Alterations in gene expression in the caput epididymides of nonobstructive azoospermic men.
Québec, Canada. In Biol Reprod, 2008
Differentially regulated genes included several encoding proteins involved in spermatozoal maturation, water and ion channels, and beta-defensins: CRISP1, SPINLW1, FAM12B, and DEFB129 were upregulated, whereas CFTR, AQP5, KCNK4, KCNK17, SLC6A20, SLC13A3, DEFB126, and DEFB106A were downregulated.
Health interventions with girls in the juvenile justice system.
Kansas City, United States. In Womens Health Issues, 2007
To address the interrelated sexual and dating violence risk behaviors of this population, we compared the relative impact of a 6-hour, peer-led group intervention, Girl Talk-2, whose goal was to decrease sexual and dating violence risk behaviors, with the impact of a comparison group in which the same information was presented in a standard lecture and video format.
A Ba2+-resistant, acid-sensitive K+ conductance in Na+-absorbing H441 human airway epithelial cells.
Dundee, United Kingdom. In Am J Physiol Lung Cell Mol Physiol, 2007
Analyses using RT-PCR showed that mRNA encoding several two-pore domain K(+) (K2P) channels was detected in cells grown under standard conditions (TWIK-1, TREK-1, TASK-2, TWIK-2, KCNK-7, TASK-3, TREK-2, THIK-1, and TALK-2).