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Potassium channel, subfamily K, member 16

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: TASK-2, TALK-2, TASK-3, K2P, ACID
Papers on TALK-1
Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.
Jacobson et al., Nashville, United States. In Diabetes, Nov 2015
Here, we show that TALK-1 channels are expressed in mouse and human β-cells, where they serve as key regulators of electrical excitability and GSIS.
Modulation of K2P3.1 (TASK-1), K2P9.1 (TASK-3), and TASK-1/3 heteromer by reactive oxygen species.
Kim et al., North Chicago, United States. In Pflugers Arch, 2012
Other K(2P) channels (TREK-1, TREK-2, TASK-2, TALK-1, TRESK) were not affected by H(2)O(2) (tested up to 326 mM).
Gating of a pH-sensitive K(2P) potassium channel by an electrostatic effect of basic sensor residues on the selectivity filter.
Niemeyer et al., Valdivia, Chile. In Plos One, 2010
Leak K(2P) K(+) channels TASK-2, TALK-1 and TALK-2 are gated open by extracellular alkalinization.
Neutralization of a single arginine residue gates open a two-pore domain, alkali-activated K+ channel.
Sepúlveda et al., Valdivia, Chile. In Proc Natl Acad Sci U S A, 2007
TASK-2, TALK-1, and TALK-2 are two-pore region (2P) KCNK K+ channels gated open by extracellular alkalinization.
Molecular characterization and expression of a two-pore domain potassium channel in the CNS of Aplysia californica.
Moroz et al., United States. In Brain Res, 2006
However, the overall identity is much lower (24% with human TALK-1) and phylogenetic analysis indicates that AcK2p2 cannot be grouped into any established mammalian subclass.
Zinc and mercuric ions distinguish TRESK from the other two-pore-domain K+ channels.
Enyedi et al., Budapest, Hungary. In Mol Pharmacol, 2006
The specificity of the identified agents was determined by measuring their effects on mouse TALK-1, TASK-1, TASK-2, TASK-3, THIK-1, TRAAK, TREK-1, and TREK-2.
Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species.
Lazdunski et al., Antibes, France. In J Physiol, 2005
This study firstly shows with in situ hybridization on human pancreas that TALK-1 and TALK-2, two members of the 2P domain potassium channel (K(2P)) family, are highly and specifically expressed in the exocrine pancreas and absent in Langherans islets.
Taste receptor cells express pH-sensitive leak K+ channels.
Gilbertson et al., Aurora, United States. In J Neurophysiol, 2004
We report here that rat taste receptor cells (TRCs) highly express TASK-2 (KCNK5; K2p5.1), and to a much lesser extent TALK-1 (KCNK16; K2p16.1) and TASK-1 (KCNK3; K2p3.1), and suggest potentially important roles for these channels in setting resting membrane potentials and in sour taste transduction.
Single-channel properties and pH sensitivity of two-pore domain K+ channels of the TALK family.
Kim et al., North Chicago, United States. In Biochem Biophys Res Commun, 2004
The two-pore K2P channel family comprises TASK, TREK, TWIK, TRESK, TALK, and THIK subfamilies, and TALK-1, TALK-2, and TASK-2 are functional members of the TALK subfamily.
Characterization of a 6p21 translocation breakpoint in a family with idiopathic generalized epilepsy.
Serratosa et al., Madrid, Spain. In Epilepsy Res, 2003
The genomic sequence of this PAC clone contains two 2-pore potassium channel genes, TALK-1 and TALK-2.
Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.
Kim et al., North Chicago, United States. In Am J Physiol Cell Physiol, 2003
at least two functional TALK-1 variants are present and may serve as background K+ currents in certain cells of the human pancreas.
Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.
Lesage et al., Antibes, France. In Biochem Biophys Res Commun, 2001
The first two subunits, TALK-1 and TALK-2, are distantly related to TASK-2.
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