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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Mitogen-activated protein kinase kinase kinase 7

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, p38, JNK, NF-kappaB, MAPK
Papers using TAK1 antibodies
IL-18 induces a marked gene expression profile change and increased Ccl1 (I-309) production in mouse mucosal mast cell homologs
Tan Nguan Soon et al., In The Journal of Cell Biology, 2007
... and neutralizing antibodies against IL-1α, IL-1β, KGF, IL-6, and GMCSF (PeproTech); anti–c-Jun, antiphospho(Ser63)–c-Jun, anti-TAK1, and antiphospho-TAK1 (Cell Signaling Technology); and Alexa Fluor ...
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
Marrack Philippa, In PLoS Biology, 2006
These antibodies were used for western blotting: BCL10 (Santa Cruz); CARD11, IκBα, pJNK, JNK, TAK1 (Cell Signaling).
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
Borthwick Lee A. et al., In The American Journal of Pathology, 2004
... TAK1 (4505; Cell Signaling, Danvers, MA), phospho-TAK1 (4536; ...
PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1
Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 2004
... Anti–phospho-PKCβ (T 500) Ab, anti-PKCβII Ab, anti-CARMA1 Ab, and anti-TAK1 Ab were obtained from Abcam.
I-kappa B kinases alpha and beta have distinct roles in regulating murine T cell function.
Simas J. Pedro, In PLoS ONE, 2001
... TAK1 inhibitor 5Z-7-oxo-zeaenol was purchased from Tocris Bioscience (Ellisville, MO), recombinant ...
Papers on TAK1
PGC-1β suppresses saturated fatty acid-induced macrophage inflammation by inhibiting TAK1 activation.
Xia et al., Guangzhou, China. In Iubmb Life, Feb 2016
Mechanistically, we revealed that TGF-β-activated kinase 1 (TAK1) and its adaptor protein TAK1 binding protein 1 (TAB1) played a dominant role in the regulatory effects of PGC-1β.
Increased Expression of Interleukin-36, a Member of the Interleukin-1 Cytokine Family, in Inflammatory Bowel Disease.
Andoh et al., Ōtsu, Japan. In Inflamm Bowel Dis, Feb 2016
Stimulation with IL-36α and IL-36γ assembled MyD88 adaptor proteins (MyD88, TRAF6, IRAK1, and TAK1) into a complex and induced the activation of NF-κB and AP-1 and also the phosphorylation of MAPKs.
IRE1-dependent activation of AMPK promotes B. abortus intracellular growth.
Peng et al., Changchun, China. In J Bacteriol, Feb 2016
The known AMPK kinases LKB1, CAMKKβ, and TAK1 are not required for the activation of AMPK by B. abortus infection.
miR-892b silencing activates NF-κB and promotes aggressiveness in breast cancer.
Li et al., Shiqi, China. In Cancer Res, Feb 2016
Furthermore, we demonstrate that miR-892b attenuated NF-κB signaling by directly targeting and suppressing multiple mediators of NF-κB, including TRAF2, TAK1, and TAB3, and thus, miR-892b silencing in breast cancer cells sustains NF-κB activity.
CREB/GSK-3β signaling pathway regulates the expression of TR4 orphan nuclear receptor gene.
Kim et al., South Korea. In Mol Cell Endocrinol, Feb 2016
UNASSIGNED: In this study, we show that reduction of glucose concentration increases TR4 expression in 3T3-L1 cells via stimulation of the GSK-3β-CREB pathway.
Fusarium Wilt of Banana.
Ploetz, Homestead, United States. In Phytopathology, Dec 2015
The history and impact of Fusarium wilt is summarized with an emphasis on tropical race 4 (TR4), a 'Cavendish'-killing variant of the pathogen that has spread dramatically in the Eastern Hemisphere.
The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells.
Chen et al., Bethesda, United States. In Nat Immunol, Oct 2015
Mechanistically, TGF-β1 and IL-4 downregulated Id3 expression, and this process required the kinase TAK1.
The New Molecular Landscape of Cushing's Disease.
Allolio et al., Würzburg, Germany. In Trends Endocrinol Metab, Oct 2015
Its molecular basis has remained poorly understood until the past few years, when several proteins and genes [such as testicular orphan nuclear receptor 4 (TR4) and heat shock protein 90 (HSP90)] were found to play key roles in the disease.
Metabolic reprogramming and cell fate regulation in alcoholic liver disease.
Tsukamoto, Los Angeles, United States. In Pancreatology, Jul 2015
For M1 HM activation, heightened proinflammatory iron redox signaling in endosomes or caveosomes results from altered iron metabolism and storage, promoting IKK/NF-kB activation via interactive activation of p21ras, TAK1, and PI3K.
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.
Nold et al., Melbourne, Australia. In Nat Immunol, Apr 2015
Proteomic and transcriptomic investigations revealed that IL-37 used IL-1R8 to harness the anti-inflammatory properties of the signaling molecules Mer, PTEN, STAT3 and p62(dok) and to inhibit the kinases Fyn and TAK1 and the transcription factor NF-κB, as well as mitogen-activated protein kinases.
Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.
Fan et al., Beijing, China. In Nat Immunol, Apr 2015
Upon challenge with bacterial DNA, Sox2 dimerization was needed to activate a complex of the kinase TAK1 and its binding partner TAB2, which led to activation of the transcription factors NF-κB and AP-1 in neutrophils.
TR4 Nuclear Receptor Different Roles in Prostate Cancer Progression.
Chang et al., Rochester, United States. In Front Endocrinol (lausanne), 2014
In this review, we summarize the current findings regarding the nuclear receptor TR4 and its role in prostate cancer (PCa) progression.
TAK1 selective inhibition: state of the art and future opportunities.
Jones et al., Cambridge, United States. In Future Med Chem, 2014
The mitogen activated protein kinase kinase kinase transforming growth factor-β-activated kinase 1 (TAK1) has emerged as an interesting therapeutic target for inflammatory diseases and cancer.
Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation.
Okada-Hatakeyama et al., Yokohama, Japan. In Science, 2014
We show that the CARD-containing MAGUK protein 1 (CARMA1, also called CARD11)-TAK1 (MAP3K7)-inhibitor of NF-κB (IκB) kinase-β (IKKβ) module is a switch mechanism for NF-κB activation in B cell receptor (BCR) signaling.
SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.
Yamagata et al., Kumamoto, Japan. In Cell Metab, 2014
Hepatic SIRT7 positively regulated the protein level of TR4/TAK1, a nuclear receptor involved in lipid metabolism, and as a consequence activated TR4 target genes to increase fatty acid uptake and triglyceride synthesis/storage.
Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling.
Silverman et al., Worcester, United States. In Proc Natl Acad Sci U S A, 2012
evidence that TAK1 is a target for YopJ-mediated inhibition.
Essential role of TAK1 in regulating mantle cell lymphoma survival.
Younes et al., Houston, United States. In Blood, 2012
The phosphorylated form of TAK1 is abundantly expressed in a panel of lymphoma cell lines, including mantle cell, anaplastic large cell, and Hodgkin lymphoma. siRNA inhibited the activation of NF-kappaB and p38 and induced apoptosis in lymphoma cell lines.
Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer.
Talianidis et al., Greece. In Cancer Cell, 2012
Results show that, in the liver, CYLD acts as an important regulator of hepatocyte homeostasis, protecting cells from spontaneous apoptosis by preventing uncontrolled TAK1 and JNK activation.
Mycobacterium tuberculosis modulates macrophage lipid-sensing nuclear receptors PPARγ and TR4 for survival.
Gupta et al., Chandīgarh, India. In J Immunol, 2012
Mycobacterium tuberculosis interacts with macrophage lipids and human host testicular receptor (TR)4 to ensure survival of the pathogen by modulating macrophage function.
Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC.
Chaudhary et al., Los Angeles, United States. In Plos One, 2011
Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-kappaB pathway independent of TRAF6, TAK1 and LUBAC
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