Novel arylazopyrazole inhibitors of cyclin-dependent kinases.
Olomouc, Czech Republic. In Bioorg Med Chem, 01 Jun 2015
Here, we describe new 4-arylazo-3,5-diamino-1H-pyrazole derivatives developed from CAN508, one of the first inhibitors to show preference for transcriptional regulator cyclin-dependent kinase 9.
QTLs underlying natural variation of root growth angle among rice cultivars with the same functional allele of DEEPER ROOTING 1.
Tsukuba, Japan. In Rice (n Y), Dec 2014
To elucidate genetic factors related to such variation, we quantitatively measured RGA using the basket method and analyzed quantitative trait loci (QTLs) for RGA in three F2 mapping populations derived from crosses between the large RGA-type cultivar Kinandang Patong and each of three accessions with varying RGA: Momiroman has small RGA and was used to produce the MoK-F2 population; Yumeaoba has intermediate RGA (YuK-F2 population); Tachisugata has large RGA (TaK-F2 population).
Recent advances in Takayasu arteritis.
Kyoto, Japan. In Int J Rheum Dis, Mar 2014
Takayasu arteritis (TAK) is a relatively rare systemic vasculitis mainly affecting the aorta and its large branches.