Recent advances in Takayasu arteritis.
Kyoto, Japan. In Int J Rheum Dis, 18 Mar 2014
UNLABELLED: Takayasu arteritis (TAK) is a relatively rare systemic vasculitis mainly affecting the aorta and its large branches.
Comparative drug screening in NUT midline carcinoma.
Perth, Australia. In Br J Cancer, 11 Mar 2014
UNLABELLED: Background:The NUT midline carcinoma (NMC) is a rare but fatal cancer for which systematic testing of therapy options has never been performed.Methods:On the basis of disease biology, we compared the efficacy of the CDK9 inhibitor flavopiridol (FP) with a panel of anticancer agents in NMC cell lines and mouse xenografts.Results:In vitro anthracyclines, topoisomerase inhibitors, and microtubule poisons were among the most cytotoxic drug classes for NMC cells, while efficacy of the bromodomain inhibitor JQ1 varied considerably between lines carrying different BRD4 (bromodomain-containing protein 4)-NUT (nuclear protein in testis) translocations.
Efficacy and toxicity of factor Xa inhibitors.
Marseille, France. In J Pharm Pharm Sci, 2012
New antithrombotics such as rivaroxaban, apixaban, betrixaban, edoxaban, darexaban, TAK-442, LY517717, eribaxaban, otamixaban are being developed to overcome current therapeutic limitations.