GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 27 Nov 2013.
Cyclin-dependent kinase 9
TAK, CDK9, Cyclin-Dependent Kinase 9
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers using
TAK
antibodies
Identification of the vesicular nucleotide transporter (VNUT) in taste cells.
Supplier
In PLoS ONE, 2008
... Slices containing vallate taste buds were mounted on a glass coverslip coated with Cell-Tak (Becton Dickinson, Franklin Lakes, NJ, USA), ...
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
Supplier
In Retrovirology, 1995
... Anti-myc, anti-HA, anti-CycT1, anti-Cdk9, and anti-Ub antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on
TAK
Screening of kinase inhibitors targeting BRAF for regulating autophagy based on kinase pathways.
New
Harbin, China. In Mol Med Report, 31 Jan 2014
Previous studies indicated that sorafenib is capable of regulating autophagy and regorafenib has also been reported; however, there have been no studies regarding the regulation of autophagy by afatinib, selumetinib, PD318088, axitinib, TAK-733, GDC-0980, GSK2126458, PLX-4720, AS703026, trametinib, GDC-0941 and PF-04217903.
Copy number variations in endoglin locus: mapping of large deletions in Spanish families with hereditary hemorrhagic telangiectasia type 1.
New
In Bmc Med Genet, 25 Dec 2013
RESULTS: All tested families carried large deletions ranging from 3-kb to 100-kb, involving the ENG gene promoter, several ENG exons, and the two downstream genes FGSH and CDK9.
G-protein coupled receptor 40 agonists as novel therapeutics for type 2 diabetes.
New
South Korea. In Arch Pharm Res, 15 Dec 2013
There are a number of lead molecules targeting GPR40, and among these molecules TAK-875 (full agonist) and AMG 837 (partial agonist) advanced into clinical stage.
Diverse modifications of the 4-methylphenyl moiety of TAK-779 by late-stage Suzuki-Miyaura cross-coupling.
New
Münster, Germany. In Org Biomol Chem, 12 Dec 2013
TAK-779 displays high affinity and selectivity for the CCR5 receptor and serves as a lead compound for the development of further antagonists.
Beyond abiraterone: New hormonal therapies for metastatic castration-resistant prostate cancer.
Review
New
Madrid, Spain. In Cancer Biol Ther, 07 Nov 2013
New androgen biosynthesis inhibitors have been developed, such as orteronel (TAK-700), but also new antiandrogens (enzalutamide, ARN-509, ODM-201) or even agents with a dual mechanism of action (galeterone).
HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.
New
Impact
Boulder, United States. In Cell, Jul 2013
HIF1A induces binding of CDK8-Mediator and the super elongation complex (SEC), containing AFF4 and CDK9, to alleviate RNAPII pausing.
Emerging therapies in metastatic castration-sensitive and castration-resistant prostate cancer.
Review
New
Chicago, United States. In Curr Opin Oncol, May 2013
Trials with additional agents targeting androgen receptor (AR) signaling, such as TAK-700 and enzalutamide, are ongoing.
Targeting the adrenal gland in castration-resistant prostate cancer: a case for orteronel, a selective CYP-17 17,20-lyase inhibitor.
Review
New
Cleveland, United States. In Curr Oncol Rep, Apr 2013
A new CYP17 inhibitor, with more selective inhibition of 17,20-lyase over 17α-hydroxylase, orteronel (TAK-700), is currently undergoing phase III clinical trials in pre- and postchemotherapy CRPC.
Lost in transcription: molecular mechanisms that control HIV latency.
Review
New
Beersheba, Israel. In Viruses, Mar 2013
Among these, transcriptional repression as a result of reduced levels and activity of the positive transcription elongation factor b (P-TEFb: CDK9/cyclin T) plays a significant role.
Inhibition of cdk9 during Herpes Simplex Virus 1 Infection Impedes Viral Transcription.
New
Irvine, United States. In Plos One, Dec 2012
Cellular kinase cdk9 phosphorylates serine-2 in the C-terminal domain (CTD) of RNAP II.
Efficacy and toxicity of factor Xa inhibitors.
Review
New
Marseille, France. In J Pharm Pharm Sci, Dec 2012
New antithrombotics such as rivaroxaban, apixaban, betrixaban, edoxaban, darexaban, TAK-442, LY517717, eribaxaban, otamixaban are being developed to overcome current therapeutic limitations.
TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial.
New
Impact
Ann Arbor, United States. In Lancet, May 2012
We aimed to assess whether selective pharmacological activation of this receptor by TAK-875 in patients with type 2 diabetes mellitus improved glycaemic control without hypoglycaemia risk.
RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing.
Impact
New York City, United States. In Science, 2011
Like Ser(2), Thr(4) phosphorylation requires the CTD kinase CDK9 and is evolutionarily conserved from yeast to human.
Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.
GeneRIF
Ljubljana, Slovenia. In Nucleic Acids Res, 2011
The inhibition of CDK9, the kinase subunit of P-TEFb, inhibited AIRE-induced pre-mRNA splicing of these genes.
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
GeneRIF
New York City, United States. In Proc Natl Acad Sci U S A, 2011
Data show that the minimal 90-amino acid AF9 fragment in MLL-AF9 retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1.
Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.
GeneRIF
Pune, India. In J Biol Chem, 2011
Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.
Recruitment of cyclin-dependent kinase 9 to nuclear compartments during cytomegalovirus late replication: importance of an interaction between viral pUL69 and cyclin T1.
GeneRIF
Erlangen, Germany. In J Gen Virol, 2011
HCMV inter-regulation with CDK9/cyclin T1 is at least partly based on a pUL69-cylin T1 interaction.
The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation.
GeneRIF
Taejŏn, South Korea. In Bmc Dev Biol, 2010
Data show that the CDK9 and cyclin T1 subunits of P-TEFb are present in mouse oocytes and preimplantation embryos, and that CDK9 is essential for embryonic genome activation in the mouse.
Crystal structure of HIV-1 Tat complexed with human P-TEFb.
Impact
Omaha, United States. In Nature, 2010
Here we describe the crystal structure of the Tat.P-TEFb complex containing HIV-1 Tat, human Cdk9 (also known as CDK9), and human cyclin T1 (also known as CCNT1).
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.
Impact
GeneRIF
New York City, United States. In Cell, 2009
As receptor-activated Smads form transcriptional complexes, they are phosphorylated at an interdomain linker region by CDK8 and CDK9, which are components of transcriptional mediator and elongation complexes.
