GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 24 Feb 2014.
Cyclin-dependent kinase 9
TAK, CDK9, Cyclin-Dependent Kinase 9
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008] (from
NCBI)
Papers using
TAK
antibodies
Identification of the vesicular nucleotide transporter (VNUT) in taste cells.
Supplier
In PLoS ONE, 2008
... Slices containing vallate taste buds were mounted on a glass coverslip coated with Cell-Tak (Becton Dickinson, Franklin Lakes, NJ, USA), ...
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
Supplier
In Retrovirology, 1995
... Anti-myc, anti-HA, anti-CycT1, anti-Cdk9, and anti-Ub antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Papers on
TAK
Recent advances in Takayasu arteritis.
New
Kyoto, Japan. In Int J Rheum Dis, 18 Mar 2014
UNLABELLED: Takayasu arteritis (TAK) is a relatively rare systemic vasculitis mainly affecting the aorta and its large branches.
SAHA (vorinostat) induces CDK9 Thr186 (T-loop) phosphorylation in resting CD4+ T-cells - implications for reactivation of latent HIV.
New
Houston, United States. In Aids Res Hum Retroviruses, 14 Mar 2014
It is possible that SAHA reactivation of latent viruses may involve effects on cellular transcription factors such as P-TEFb, a protein kinase whose core is composed of CDK9 and Cyclin T1.
Diversity and population structure of Plasmodium falciparum in Thailand based on the spatial and temporal haplotype patterns of the C-terminal 19-kDa domain of merozoite surface protein-1.
New
In Malar J, 12 Mar 2014
In Thailand, PfMSP-119 sequences have been derived from a single parasite population in Tak province, located along the Thailand-Myanmar border, since 1995.
Comparative drug screening in NUT midline carcinoma.
New
Perth, Australia. In Br J Cancer, 11 Mar 2014
UNLABELLED: Background:The NUT midline carcinoma (NMC) is a rare but fatal cancer for which systematic testing of therapy options has never been performed.Methods:On the basis of disease biology, we compared the efficacy of the CDK9 inhibitor flavopiridol (FP) with a panel of anticancer agents in NMC cell lines and mouse xenografts.Results:In vitro anthracyclines, topoisomerase inhibitors, and microtubule poisons were among the most cytotoxic drug classes for NMC cells, while efficacy of the bromodomain inhibitor JQ1 varied considerably between lines carrying different BRD4 (bromodomain-containing protein 4)-NUT (nuclear protein in testis) translocations.
Release of P-TEFb from 7SK snRNP Activates HEXIM1 Transcription.
New
United States. In J Biol Chem, 10 Mar 2014
UNLABELLED: By phosphorylating negative elongation factors and the C-terminal domain of RNA polymerase II, P-TEFb, which is composed of CycT1 or CycT2 and CDK9, activates eukaryotic transcription elongation.
Regulation of CDK9 Activity by Phosphorylation and Dephosphorylation.
Review
New
Washington, D.C., United States. In Biomed Res Int, Dec 2013
UNLABELLED: HIV-1 transcription is regulated by CDK9/cyclin T1, which, unlike a typical cell cycle-dependent kinase, is regulated by associating with 7SK small nuclear ribonuclear protein complex (snRNP).
Beyond abiraterone: New hormonal therapies for metastatic castration-resistant prostate cancer.
Review
New
Madrid, Spain. In Cancer Biol Ther, Nov 2013
New androgen biosynthesis inhibitors have been developed, such as orteronel (TAK-700), but also new antiandrogens (enzalutamide, ARN-509, ODM-201) or even agents with a dual mechanism of action (galeterone).
HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.
New
Impact
Boulder, United States. In Cell, Jul 2013
HIF1A induces binding of CDK8-Mediator and the super elongation complex (SEC), containing AFF4 and CDK9, to alleviate RNAPII pausing.
Cyclin-dependent kinase inhibitor therapy for hematologic malignancies.
Review
New
Richmond, United States. In Expert Opin Investig Drugs, Jun 2013
Certain CDKs (e.g., CDK7, CDK9) also control cellular transcription.
Lost in transcription: molecular mechanisms that control HIV latency.
Review
New
Beersheba, Israel. In Viruses, Mar 2013
Among these, transcriptional repression as a result of reduced levels and activity of the positive transcription elongation factor b (P-TEFb: CDK9/cyclin T) plays a significant role.
Efficacy and toxicity of factor Xa inhibitors.
Review
Marseille, France. In J Pharm Pharm Sci, 2012
New antithrombotics such as rivaroxaban, apixaban, betrixaban, edoxaban, darexaban, TAK-442, LY517717, eribaxaban, otamixaban are being developed to overcome current therapeutic limitations.
TAK-875 versus placebo or glimepiride in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial.
Impact
Ann Arbor, United States. In Lancet, 2012
We aimed to assess whether selective pharmacological activation of this receptor by TAK-875 in patients with type 2 diabetes mellitus improved glycaemic control without hypoglycaemia risk.
RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing.
Impact
New York City, United States. In Science, 2011
Like Ser(2), Thr(4) phosphorylation requires the CTD kinase CDK9 and is evolutionarily conserved from yeast to human.
Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.
GeneRIF
Ljubljana, Slovenia. In Nucleic Acids Res, 2011
The inhibition of CDK9, the kinase subunit of P-TEFb, inhibited AIRE-induced pre-mRNA splicing of these genes.
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
GeneRIF
New York City, United States. In Proc Natl Acad Sci U S A, 2011
Data show that the minimal 90-amino acid AF9 fragment in MLL-AF9 retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1.
Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.
GeneRIF
Pune, India. In J Biol Chem, 2011
Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.
Recruitment of cyclin-dependent kinase 9 to nuclear compartments during cytomegalovirus late replication: importance of an interaction between viral pUL69 and cyclin T1.
GeneRIF
Erlangen, Germany. In J Gen Virol, 2011
HCMV inter-regulation with CDK9/cyclin T1 is at least partly based on a pUL69-cylin T1 interaction.
The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation.
GeneRIF
Taejŏn, South Korea. In Bmc Dev Biol, 2010
Data show that the CDK9 and cyclin T1 subunits of P-TEFb are present in mouse oocytes and preimplantation embryos, and that CDK9 is essential for embryonic genome activation in the mouse.
Crystal structure of HIV-1 Tat complexed with human P-TEFb.
Impact
Omaha, United States. In Nature, 2010
Here we describe the crystal structure of the Tat.P-TEFb complex containing HIV-1 Tat, human Cdk9 (also known as CDK9), and human cyclin T1 (also known as CCNT1).
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.
Impact
GeneRIF
New York City, United States. In Cell, 2009
As receptor-activated Smads form transcriptional complexes, they are phosphorylated at an interdomain linker region by CDK8 and CDK9, which are components of transcriptional mediator and elongation complexes.
