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TAF7-like RNA polymerase II, TATA box binding protein

TAF7L, TFIID TATA box-binding protein-associated factor, CT-40
This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] (from NCBI)
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Top mentioned proteins: TBP, TAF7, MEN, CAN, USP26
Papers on TAF7L
Non-synonymous mutations mapped to chromosome X associated with andrological and growth traits in beef cattle.
Moore et al., Jaboticabal, Brazil. In Bmc Genomics, 2014
The SNPs that had a major influence in percentage of normal sperm were mapped to LOC100138021 and TAF7L genes; and in TEX11 and AR genes for scrotal circumference.
Cancer/Testis OIP5 and TAF7L Genes are Up-Regulated in Breast Cancer.
Modarressi et al., Tehrān, Iran. In Asian Pac J Cancer Prev, 2014
We conducted the present study to analyze transcript changes of two cancer/testis antigens, OIP5 and TAF7L, in breast tumors and cell lines in comparison with normal breast tissues by quantitative real time RT-PCR for the first time.
TAF7L modulates brown adipose tissue formation.
Tjian et al., Berkeley, United States. In Elife, 2013
Previously, we reported that the TATA-binding protein associated factor 7L (TAF7L) is an important regulator of white adipose tissue (WAT) differentiation.
Taf7l cooperates with Trf2 to regulate spermiogenesis.
Tjian et al., Berkeley, United States. In Proc Natl Acad Sci U S A, 2013
TATA-binding protein (TBP)-associated factor 7l (Taf7l; a paralogue of Taf7) and TBP-related factor 2 (Trf2) are components of the core promoter complex required for gene/tissue-specific transcription of protein-coding genes by RNA polymerase II.
Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern.
Modarressi et al., Tehrān, Iran. In Med Oncol, 2013
To find new CTA genes in AML, we analyzed the expression pattern of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L using real-time quantitative PCR in 51 AMLs and 6 myelodysplastic syndrome cases in comparison with 33 healthy controls.
Dual functions of TAF7L in adipocyte differentiation.
Tjian et al., Berkeley, United States. In Elife, 2012
Here we report that TAF7L, a paralogue of TFIID subunit TAF7, is enriched in adipocytes and white fat tissue (WAT) in mouse.
Genetic analysis of contiguous X-chromosome deletion syndrome encompassing the BTK and TIMM8A genes.
Oh-ishi et al., Saitama, Japan. In J Hum Genet, 2011
Patient 1 had a 63-kb deletion with break points in intron 15 of BTK and 4 kb upstream of TAF7L.
[Sex chromosomes and male infertility].
Huang et al., Nanjing, China. In Zhonghua Nan Ke Xue, 2010
The importance of the X chromosome in mammalian spermatogenesis is suggested by its enrichment of germ cell-specific genes expressed in spermatogenesis, such as AR, USP26, TAF7L, TEX11, KAL1, AKAP4, and NXF2.
Male infertility and the involvement of the X chromosome.
Lissens et al., Brussels, Belgium. In Hum Reprod Update, 2009
In the second part of the study, the results of mutation analyses of seven genes (AR, SOX3, USP26, NXF2, TAF7L, FATE and AKAP4) are described.
[Genetics and male infertility].
Lissens et al., Brussels, Belgium. In Verh K Acad Geneeskd Belg, 2008
The genes NXF2, USP26 and TAF7L were investigated for the presence of mutations.
Quantitative measurements obtained by micro-computed tomography and confocal laser scanning microscopy.
Kaffe et al., Ankara, Turkey. In Dentomaxillofac Radiol, 2008
Four artificial internal resorption cavities were prepared with standardized burs on each section, and diameters and volumes were measured using a laser scanning electron confocal microscope and a desktop cone beam micro-CT-40.
Gene polymorphisms and male infertility--a meta-analysis and literature review.
Simoni et al., Münster, Germany. In Reprod Biomed Online, 2007
Genes encoding nuclear proteins (PRM1/2, TNP1/2) and ER1 are possible candidates for further examination, while the role of TAF7L remains unclear.
Contiguous X-chromosome deletion syndrome encompassing the BTK, TIMM8A, TAF7L, and DRP2 genes.
Ochs et al., Praha, Czech Republic. In J Clin Immunol, 2007
Mutation analysis of the BTK gene revealed gross deletions of different lengths in all patients, in one case extending approximately 196 kb, including the genes TIMM8A, TAF7L, and DRP2.
Mutation analysis of the X-chromosome linked, testis-specific TAF7L gene in spermatogenic failure.
Simoni et al., Nigeria. In Andrologia, 2007
The sequence variant in exon 13 of the TAF7L gene located on the X chromosome may represent a risk factor for spermatogenic failure.
The role of the testis-specific gene hTAF7L in the aetiology of male infertility.
Liebaers et al., Brussels, Belgium. In Mol Hum Reprod, 2006
TAF7L gene polymorphisms were found in male infertility patients and normal controls.
Testis-specific transcription mechanisms promoting male germ-cell differentiation.
Sassone-Corsi et al., Strasbourg, France. In Reproduction, 2004
Interestingly TBP-associated factor (TAF7), a factor of the transcription factor (TF)IID complex, is exchanged at a critical stage in germ cell development for the testis-specific paralogue TAF7L.
Induced alpha helix in the VP16 activation domain upon binding to a human TAF.
Verdine et al., Cambridge, United States. In Science, 1997
A combination of nuclear magnetic resonance (NMR) and biochemical experiments revealed that the minimal acidic activation domain of the herpes simplex virus VP16 protein undergoes an induced transition from random coil to alpha helix upon binding to its target protein, hTAFII31 (a human TFIID TATA box-binding protein-associated factor).
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