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TAF7 RNA polymerase II, TATA box binding protein

TAF7, TAF(II)55, hTAF(II)55, TAFII55, hTAFII55, TAF67
The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TBP, POLYMERASE, TAF, CAN, Histone
Papers on TAF7
Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module.
Zheng et al., Seattle, United States. In Cell Res, 2014
Here, we present the crystal structure of the human TAF1 central core domain in complex with another conserved TFIID subunit, TAF7, which biochemically solubilizes TAF1.
MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex.
Hatakeyama et al., Sapporo, Japan. In Nat Commun, 2014
Our results suggest that the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes.
Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D.
Webb et al., Houston, United States. In Proc Natl Acad Sci U S A, 2014
TATA binding protein-associated factors 1 and 7 (TAF1 and TAF7), two subunits of TFIID, are integral to the regulation of eukaryotic transcription initiation and play key roles in preinitiation complex (PIC) assembly.
Transcriptional coactivator CIITA, a functional homolog of TAF1, has kinase activity.
Singer et al., Bethesda, United States. In Biochim Biophys Acta, 2013
Its substrate specificity parallels, but does not duplicate, that of TAF1 in phosphorylating the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF and histone H2B.
Taf7l cooperates with Trf2 to regulate spermiogenesis.
Tjian et al., Berkeley, United States. In Proc Natl Acad Sci U S A, 2013
TATA-binding protein (TBP)-associated factor 7l (Taf7l; a paralogue of Taf7) and TBP-related factor 2 (Trf2) are components of the core promoter complex required for gene/tissue-specific transcription of protein-coding genes by RNA polymerase II.
Gene expression profile of a newly established choriocarcinoma cell line, iC3-1, compared to existing choriocarcinoma cell lines and normal placenta.
Aoki et al., Tokyo, Japan. In Placenta, 2013
Bioinformatics analysis showed that several characteristic genes, IGF1R, CHFR, MUC3A, TAF7, PARK7, CDC123 and PSMD8, were significantly upregulated in iC(3)-1 compared to BeWo and JEG3 cells.
TAF7: traffic controller in transcription initiation.
Review
Singer et al., Bethesda, United States. In Transcription, 2013
TAF7, a component of the TFIID complex, controls the first steps of transcription.
Dual functions of TAF7L in adipocyte differentiation.
Tjian et al., Berkeley, United States. In Elife, 2012
Here we report that TAF7L, a paralogue of TFIID subunit TAF7, is enriched in adipocytes and white fat tissue (WAT) in mouse.
Cross-talk among RNA polymerase II kinases modulates C-terminal domain phosphorylation.
Singer et al., Bethesda, United States. In J Biol Chem, 2012
Additionally, the three kinases regulate each other indirectly through the general transcription factor TAF7.
Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7.
GeneRIF
Wang et al., Seattle, United States. In Mol Cell Biol, 2012
analysis of phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7
The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells.
Singer et al., Bethesda, United States. In Mol Cell Biol, 2012
TAF7, a component of the TFIID complex that nucleates the assembly of transcription preinitiation complexes, also independently interacts with and regulates the enzymatic activities of other transcription factors, including P-TEFb, TFIIH, and CIITA, ensuring an orderly progression in transcription initiation.
Novel functions for TAF7, a regulator of TAF1-independent transcription.
GeneRIF
Singer et al., Bethesda, United States. In J Biol Chem, 2011
TAF7, until now considered only a TFIID component and regulator of TAF1-dependent transcription, also regulates TAF1-independent transcription
The simian immunodeficiency virus targets central cell cycle functions through transcriptional repression in vivo.
Roederer et al., Bethesda, United States. In Plos One, 2010
In addition, the upregulation of the gene for the fundamental regulator of RNA polymerase II, TAF7, demonstrates that viral interference with the cell cycle and transcriptional regulation programs may be critical components during the establishment of a pathogenic infection in vivo.
TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.
GeneRIF
Singer et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2008
TAF7 interacts with the transcription factors, TFIIH and P-TEFb, resulting in the inhibition of their Pol II CTD kinase activities
Presence of the anti-leukemic nucleotide analog, 2-chloro-2'-deoxyadenosine-5'-monophosphate, in a promoter sequence alters DNA binding of TATA-binding protein (TBP).
GeneRIF
Hentosh et al., North Chicago, United States. In Arch Biochem Biophys, 2007
These results suggest normal TBP-binding interactions--specifically recognition, stability, and conformation-are disrupted by CldAMP insertion into eukaryotic promoter sequences.
TAF7: a possible transcription initiation check-point regulator.
GeneRIF
Singer et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2006
Functions as a check-point regulator suppressing premature transcription initiation until preinitiation complex assembly is complete.
Testis-specific transcription mechanisms promoting male germ-cell differentiation.
Review
Sassone-Corsi et al., Strasbourg, France. In Reproduction, 2004
Interestingly TBP-associated factor (TAF7), a factor of the transcription factor (TF)IID complex, is exchanged at a critical stage in germ cell development for the testis-specific paralogue TAF7L.
Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?
Review
Seto et al., Tampa, United States. In Gene, 1999
TBP, TFIIB, TAFII55, Sp1, and E1A) has suggested that these interactions are important for determining which particular function of YY1 is displayed at a specific promoter.
Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators.
Impact
Roeder et al., New York City, United States. In Science, 1995
The cloning of a complementary DNA encoding a human TFIID TAF, TAFII55, that has no known homolog in Drosophila TFIID is now described.
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