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TAF5 RNA polymerase II, TATA box binding protein

TAF5, hTAFII100, TAF90, TAFII100, TAFII90, hTAF(II)100, TAF(II)100
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: TBP, TAF, POLYMERASE, CAN, Histone
Papers on TAF5
Indenes and tetralenes analogues attenuates lipopolysaccharide-induced inflammation: An in-vitro and in-vivo study.
Bawankule et al., Lucknow, India. In Chem Biol Interact, Jan 2016
Among all the analogues, TAF-5 (1-Chloro-2-formyl-1-tetralene) exhibited most potent anti-inflammatory activity without any cytotoxic effect.
Soft diphosphine and diarsine complexes of niobium(V) and tantalum(V) fluorides: synthesis, properties, structures and comparisons with the corresponding chlorides.
Zhang et al., Southampton, United Kingdom. In Dalton Trans, 2014
The reactions of the soft diphosphines o-C6H4(PMe2)2, Me2P(CH2)2PMe2, Et2P(CH2)2PEt2 or o-C6H4(PPh2)2 with NbF5 or TaF5 in anhydrous MeCN solution produce [MF4(diphosphine)2][MF6] (M = Nb or Ta), which have been characterised by microanalysis, IR, (1)H, (19)F{(1)H}, (31)P{(1)H} and (93)Nb NMR spectroscopy.
Identification of suitable reference genes for gene expression studies by qRT-PCR in the blister beetle Mylabris cichorii.
Yin et al., Chongqing, China. In J Insect Sci, 2013
We recommend UBE3A and RPL22e as suitable reference genes in females and UBE3A, TAF5, and RPL22e in males.
Ligand-interchange reactions between M(IV) (M = Ti, V) oxide bis-acetylacetonates and halides of high-valent group 4 and 5 metals. A synthetic and electrochemical study.
Zacchini et al., Pisa, Italy. In Dalton Trans, 2013
The intermediate species [TaF4{OTi(acac)2}2][TaF6], 3, was intercepted in the course of the formation of 1a from TiO(acac)2/TaF5.
Long-lived radical cation salts obtained by interaction of monocyclic arenes with niobium and tantalum pentahalides at room temperature: EPR and DFT studies.
Pinzino et al., Pisa, Italy. In Chemistry, 2013
The 1:3 reactions of the alkoxy arenes 1,4-(MeO)2 C6 H4 and 1,4-F2 -2,5-(MeO)2 C6 H2 with TaF5 in chloroform at 40-50 °C resulted in formation in about 35 % yield of the long-lived radical cation salts [1,4-(MeO)2 C6 H4 ][Ta2 F11 ] (2 a) and [1,4-F2 -2,5-(MeO)2 C6 H2 ][Ta2 F11 ] (2 b), respectively.
The architecture of human general transcription factor TFIID core complex.
Berger et al., Grenoble, France. In Nature, 2013
A functional core-TFIID subcomplex was revealed in Drosophila nuclei, consisting of a subset of TAFs (TAF4, TAF5, TAF6, TAF9 and TAF12).
High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer.
Einbeigi et al., Göteborg, Sweden. In Bmc Cancer, 2012
The aim of this study was to determine the correlation of γ-glutamyl hydrolase (GGH), fatty acid amide hydrolase (FAAH), Pirin (PIR) and TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65 kDa (TAF5L), selected from identified gene signatures, with clinical outcomes as well as classical clinicopathological characteristics in primary invasive breast cancer patients.
TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.
Romier et al., Illkirch-Graffenstaden, France. In J Biol Chem, 2012
TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.
A novel TBP-TAF complex on RNA polymerase II-transcribed snRNA genes.
Murphy et al., Oxford, United Kingdom. In Transcription, 2012
Although TAF5 has been shown to be associated with RNAP II-transcribed snRNA genes, the full complement of TAFs associated with these genes has remained unclear.
Network biology of tumor stem-like cells identified a regulatory role of CBX5 in lung cancer.
Chiou et al., Taipei, Taiwan. In Sci Rep, 2011
Topologically-weighted measurements of CBX5 were synchronized with those of BIRC5, DNMT1, E2F1, ESR1, MLH1, MSH2, RB1, SMAD1 and TAF5.
Direct transactivator-transcription factor IID (TFIID) contacts drive yeast ribosomal protein gene transcription.
Weil et al., Nashville, United States. In J Biol Chem, 2010
Here, we identify and characterize the Rap1 binding domains (RBDs) of Taf4 and Taf5.
Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplex.
Shidlovskii et al., Moscow, Russia. In Proc Natl Acad Sci U S A, 2009
The coupling of Brahma and TFIID is mediated by the SAYP factor, whose evolutionarily conserved activation domain SAY can directly bind to both BAP170 subunit of Brahma and TAF5 subunit of TFIID.
Expression analysis of TFIID in single human oocytes: new potential molecular markers of oocyte quality.
Purrello et al., Catania, Italy. In Reprod Biomed Online, 2008
TATAbox-binding protein associated factor 4B (TAF4B), TAF5 and TATAbox-binding protein-like 2 (TBPL2) are expressed at higher levels in oocytes than in control tissues.
Crystal structure, biochemical and genetic characterization of yeast and E. cuniculi TAF(II)5 N-terminal domain: implications for TFIID assembly.
Moras et al., Illkirch-Graffenstaden, France. In J Mol Biol, 2007
Results show that the N-terminal sub-domain of the TAF(II)5 N terminus dimerizes at very high concentration but is neither required for yeast viability, nor for incorporation of two TAF(II)5 molecules within TFIID and for the assembly of this complex.
Structural analysis and dimerization potential of the human TAF5 subunit of TFIID.
Jacobson et al., Houston, United States. In Proc Natl Acad Sci U S A, 2007
TAF5 protein demonstrates the ability of the N-terminal half of the TAF5 gene to form a flexible, extended dimer, a key property required for the assembly of the TFIID complex
Electroreduction of tantalum fluoride in a room temperature ionic liquid at variable temperatures.
Endres et al., Clausthal-Zellerfeld, Germany. In Phys Chem Chem Phys, 2005
The present paper deals with the electroreduction of TaF5 in the room temperature ionic liquid 1-buty-1-methyl-pyrrolidinium bis(tri-fluoromethylsulfonyl)imide ([BMP]Tf2N) at different temperatures for the sake of electrodeposition of tantalum.
SUMO-1 modification of human transcription factor (TF) IID complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5.
Oelgeschläger et al., Maglie, Italy. In J Biol Chem, 2005
reversible SUMO modification at hsTAF5 contributes to the dynamic regulation of TFIID promoter-binding activity in human cells
Histone-like TAFs within the PCAF histone acetylase complex.
Nakatani et al., Bethesda, United States. In Cell, 1998
Moreover, the PCAF complex has a novel subunit with WD40 repeats having a similarity to hTAF(II)100.
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