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TAF4b RNA polymerase II, TATA box binding protein

TAF4b, TAFII105
TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: TBP, TAF, TAF4, POLYMERASE, PLZF
Papers on TAF4b
TAF4b is required for mouse spermatogonial stem cell development.
New
Freiman et al., Providence, United States. In Stem Cells, Apr 2015
TAF4b is a gonadal-enriched component of the general transcription factor complex, TFIID, which is required for the maintenance of spermatogenesis in the mouse.
TAF4b promotes mouse primordial follicle assembly and oocyte survival.
Freiman et al., Providence, United States. In Dev Biol, 2014
TAF4b deficiency in adult female mouse models results in hallmarks of POI including stereotyped gonadotropin alterations indicative of early menopause, poor oocyte quality, and infertility.
Transcriptional control of spermatogonial maintenance and differentiation.
Review
Wilkinson et al., San Diego, United States. In Semin Cell Dev Biol, 2014
Other transcription factors that promote SSC self-renewal are expressed independently of GDNF (FOXO1, PLZF, POU5F1, and TAF4B) and thus may act in non-GDNF pathways to promote SSC cell growth or survival.
Truncating mutations in TAF4B and ZMYND15 causing recessive azoospermia.
Tolun et al., İstanbul, Turkey. In J Med Genet, 2014
RESULTS: We identified two candidate loci in each family and homozygous truncating mutations p.R611X in TAF4B in family 1 and p.K507Sfs*3 in ZMYND15 in family 2. We did not detect any mutations in these genes in a cohort of 45 azoospermic and 15 oligozoospermic men.
Targeting TBP-Associated Factors in Ovarian Cancer.
Review
Freiman et al., Providence, United States. In Front Oncol, 2013
Its ovary-enriched paralog, TAF4B, is altered in 26% of HGSC.
Estrogen responsiveness of the TFIID subunit TAF4B in the normal mouse ovary and in ovarian tumors.
Freiman et al., Providence, United States. In Biol Reprod, 2013
We have previously demonstrated that the gonadally enriched TFIID subunit TAF4B, a paralog of the general transcription factor TAF4A, is required for fertility in mice and for the proliferation of ovarian granulosa cells following hormonal stimulation.
Taf7l cooperates with Trf2 to regulate spermiogenesis.
Tjian et al., Berkeley, United States. In Proc Natl Acad Sci U S A, 2013
Importantly, histological analysis of testes revealed that Taf7l(-/Y) mice develop postmeiotic arrest at the first stage of spermiogenesis, phenotypically similar to Trf2(-/-) mice, but distinct from Taf4b(-/-) mice.
TAF4b and TAF4 differentially regulate mouse embryonic stem cells maintenance and proliferation.
Dikstein et al., Israel. In Genes Cells, 2013
TAF4b is a cell type-specific subunit of the general transcription factor TFIID.
Effects of glial cell line-derived neurotrophic factor, fibroblast growth factor 2 and epidermal growth factor on proliferation and the expression of some genes in buffalo (Bubalus bubalis) spermatogonial cells.
Manik et al., Karnāl, India. In Reprod Fertil Dev, 2012
Expression of TAF4B was higher (P<0.05) in the presence of FGF2, whereas the expression of THY1 was not affected by growth factor supplementation.
Fibronectin 1 is a potential biomarker for radioresistance in head and neck squamous cell carcinoma.
Roberg et al., Linköping, Sweden. In Cancer Biol Ther, 2011
Fourteen hub genes (CEBPA, CEBPB, CTNNB1, FN1, MYC, MYCN, PLAU, SDC4, SERPINE1, SP1, TAF4B, THBS1, TP53 and VLDLR) were identified from the IPA network analysis.
TAF4b and Jun/activating protein-1 collaborate to regulate the expression of integrin alpha6 and cancer cell migration properties.
GeneRIF
Pintzas et al., Athens, Greece. In Mol Cancer Res, 2010
We show evidence for the first time of an interdependence of TAF4b and AP-1 family members in cell type-specific promoter recognition and initiation of transcription in the context of cancer progression and EMT.
Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.
GeneRIF
Chai et al., Los Angeles, United States. In J Biol Chem, 2010
Small interfering RNA knockdown of Taf4b results in decreased cell proliferation and altered osteogenic differentiation in primary mouse embryonic maxillary mesenchymal cells.
Accelerated ovarian aging in the absence of the transcription regulator TAF4B in mice.
GeneRIF
Freiman et al., Providence, United States. In Biol Reprod, 2010
linked to the posttranscriptional control of ovarian gene expression
TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes.
GeneRIF
Dikstein et al., Israel. In J Biol Chem, 2009
Findings suggest that DNA binding by TAF4/4b-TAF12 facilitates the association of TFIID with the core promoter of a subset of genes.
Expression of the TAF4b gene is induced by MYC through a non-canonical, but not canonical, E-box which contributes to its specific response to MYC.
GeneRIF
Tsuneoka et al., Takasaki, Japan. In Int J Oncol, 2008
Expression of the TAF4b gene is induced by MYC through a non-canonical, but not canonical, E-box which contributes to its specific response to MYC.
Regulation of spermatogonial stem cell self-renewal in mammals.
Review
Brinster et al., United States. In Annu Rev Cell Dev Biol, 2007
Additionally, the non-GDNF-stimulated transcription factors Plzf and Taf4b have been implicated in regulating SSC functions.
Candidate genes for premature ovarian failure.
Review
Rajkovic et al., Nagoya, Japan. In Curr Med Chem, 2006
Transcription factors that regulate oocyte gene expression in animal models and include Nobox, Taf4b, Figla, Lhx8, Sohlh1 and Sohlh2 are likely to be key mediators of fertility in humans.
New insights into TAFs as regulators of cell cycle and signaling pathways.
Review
Mengus et al., France. In Cell Cycle, 2005
Moreover, the TAF4 subunit of TFIID negatively regulates proliferation by inhibiting activation of the TGFbeta signalling pathway by its paralogue TAF4b.
Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development.
Impact
Tjian et al., Berkeley, United States. In Science, 2001
Here, we report that the tissue-selective TAFII105 subunit of TFIID is essential for proper development and function of the mouse ovary.
Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130.
Impact
Tjian et al., Berkeley, United States. In Cell, 1996
The cDNA encoding hTAFII105 reveals a highly conserved C-terminal domain shared by hTAFII130 and oTAFII110, while the N-terminal coactivator domain has diverged significantly.
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