GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Insulin-like growth factor binding protein 7
TAF, IGFBP7, mac25, IGFBP-rP1
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011] (from
NCBI)
Top mentioned proteins:
TBP, Insulin, CAN, POLYMERASE, Histone
Papers on
TAF
Proteomic analysis of the INS-1E secretome identify novel vitamin D-regulated proteins.
New
Oslo, Norway. In Diabetes Metab Res Rev, Feb 2016
Up-regulation of proteins implicated in β-cell growth and proliferation, such as IGF2, IGFBP7 and gelsolin, suggest that 1,25-(OH)2 D3 has a positive effect on β-cell growth and proliferation.
Regulation of antisense transcription by NuA4 histone acetyltransferase and other chromatin regulatory factors.
New
Carbondale, United States. In Mol Cell Biol, Feb 2016
UNASSIGNED: NuA4 histone lysine (K) acetyltransferase (KAT) promotes transcriptional initiation of TAF (TBP-associated factor)-dependent ribosomal protein genes.
Cell-cycle arrest and acute kidney injury: the light and the dark sides.
Review
New
Pittsburgh, United States. In Nephrol Dial Transplant, Jan 2016
We recently reported results from multi-center studies where two urinary markers of cell-cycle arrest, tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) were validated for development of AKI well ahead of clinical manifestations-azotemia and oliguria.
Indenes and tetralenes analogues attenuates lipopolysaccharide-induced inflammation: An in-vitro and in-vivo study.
New
Lucknow, India. In Chem Biol Interact, Jan 2016
Among all the analogues, TAF-5 (1-Chloro-2-formyl-1-tetralene) exhibited most potent anti-inflammatory activity without any cytotoxic effect.
IGFBP7 functions as a potential lymphangiogenesis inducer in non-small cell lung carcinoma.
New
Tianjin, China. In Oncol Rep, Jan 2016
Insulin-like growth factor binding protein 7 (IGFBP7) was proven to be associated with metastatic clinicopathological features and high LVD.
Role of insulin-like growth factor-binding proteins in the pathophysiology and tumorigenesis of gastroesophageal cancers.
Review
New
San Diego, United States. In Tumour Biol, Nov 2015
The insulin family of proteins include insulin-like growth factor binding proteins (IGFBPs) that are classified into two groups based on their differential affinities to IGFs: IGF high-affinity binding proteins (IGFBP1-6) and IGF low-affinity IGFBP-related proteins (IGFBP-rP1-10).
[The newest developments of the study on anti-HIV drugs].
Review
New
In Yao Xue Xue Bao, May 2015
Tenofoviralafenamidefumarate (TAF) is a novel nucleoside analogue reverse transcriptase inhibitor that is potent and less toxicity than tenofovir (TDF).
Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways.
Memphis, United States. In Acta Neuropathol Commun, 2014
Several microRNAs found to be up-regulated in pilocytic astrocytomas are predicted to target the ERK/MAPK and NF-κB signaling pathways as well as genes involved in senescence-associated inflammation and cell cycle control.
Overview of Transforming Growth Factor β Superfamily Involvement in Glioblastoma Initiation and Progression.
Review
Taipei, Taiwan. In Asian Pac J Cancer Prev, 2014
High cell proliferation, angiogenesis and/or necrosis are histopathological features of this cancer, which has no efficient curative therapy.
Diversity in TAF proteomics: consequences for cellular differentiation and migration.
Review
Tallinn, Estonia. In Int J Mol Sci, 2013
Development is a highly controlled process of cell proliferation and differentiation driven by mechanisms of dynamic gene regulation.
IGFBP7 promoter methylation and gene expression analysis in prostate cancer.
GeneRIF
Dublin, Ireland. In J Urol, 2012
Results demonstrate that CpG methylation of IGFBP7 may represent a novel biomarker of prostate cancer and pre-invasive neoplasms
IGFBP7's susceptibility to proteolysis is altered by A-to-I RNA editing of its transcript.
GeneRIF
Bethlehem, United States. In Febs Lett, 2012
editing of IGFBP7 transcripts impacts the protein's susceptibility to proteolytic cleavage, thus providing a means for a cell to modulate its functionality through A-to-I RNA editing
IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells.
GeneRIF
Luohe, China. In J Cancer Res Clin Oncol, 2012
Transfection of IGFBP-rP1 or addition of condition medium (CM) from IGFBP-rP1-transfected cells in MCF-7 cells caused induction of a variety of senescent phenotypes.
Insulin-like growth factor binding protein 7 modulates estrogen-induced trophoblast proliferation and invasion in HTR-8 and JEG-3 cells.
GeneRIF
Beijing, China. In Cell Biochem Biophys, 2012
IGFBP7 could also inhibit the phosphorylation of ERK and the expression of PCNA, MMP2 and MMP9 in HTR-8 and JEG-3 cells.
Downregulation of insulin-like growth factor-binding protein 7 in cisplatin-resistant non-small cell lung cancer.
GeneRIF
Baltimore, United States. In Cancer Biol Ther, 2012
These findings suggest a novel molecular mechanism responsible for the tumor suppressive function of IGFBP7 in cisplatin-resistant human lung cancer.
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.
Impact
Yokohama, Japan. In Nat Genet, 2011
In addition to CFH (rs800292, P = 4.23 × 10(-15)) and ARMS2 (rs3750847, P = 8.67 × 10(-29)) loci, we identified two new susceptibility loci for exudative AMD: TNFRSF10A-LOC389641 on chromosome 8p21 (rs13278062, combined P = 1.03 × 10(-12), odds ratio = 0.73) and REST-C4orf14-POLR2B-IGFBP7 on chromosome 4q12 (rs1713985, combined P = 2.34 × 10(-8), odds ratio = 1.30).
NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.
Impact
Charlottesville, United States. In Nature, 2010
Substrate docking and mutational analysis of RCC1 defined the NRMT recognition sequence and enabled the identification of numerous new methylation targets, including SET (also known as TAF-I or PHAPII) and the retinoblastoma protein, RB.
IGFBP7 is not required for B-RAF-induced melanocyte senescence.
Impact
GeneRIF
Sydney, Australia. In Cell, 2010
Study concludes that the secreted protein IGFBP7 is dispensable for B-RAF(V600E)-induced senescence in human melanocytes.
OMA-gosh, where's that TAF?
Impact
Boston, United States. In Cell, 2008
In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition between maternal and zygotic gene expression.
Global transcriptional repression in C. elegans germline precursors by regulated sequestration of TAF-4.
Impact
Dallas, United States. In Cell, 2008
We show here that OMA-1 and OMA-2, previously shown to regulate oocyte maturation, repress transcription in P0 and P1 by binding to and sequestering in the cytoplasm TAF-4, a component critical for assembly of TFIID and the pol II preinitiation complex.
