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TAF2 RNA polymerase II, TATA box binding protein

TAF-2, TSM1, TAFII150, a TBP-associated factor
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TAF, TBP, POLYMERASE, CAN, ACID
Papers using TAF-2 antibodies
A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID
Supplier
Murphy Shona et al., In Transcription, 1997
... Antibodies against TAF2 (NBP1–21371) and TAF3 (A302–360A) were obtained from Novus Biologicals and Bethyl laboratories, respectively ...
Papers on TAF-2
Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules.
Berger et al., Grenoble, France. In Nat Commun, 2014
Here we describe a heterotrimeric TFIID subcomplex consisting of the TAF2, TAF8 and TAF10 proteins, which assembles in the cytoplasm.
Targeting TBP-Associated Factors in Ovarian Cancer.
Review
Freiman et al., Providence, United States. In Front Oncol, 2013
At the biochemical level, TAF2 directs TFIID to TATA-less promoters by contact with an Initiator element, which may lead to the deregulation of the transcriptional output of these tumor cells.
Frequent MYC coamplification and DNA hypomethylation of multiple genes on 8q in 8p11-p12-amplified breast carcinomas.
Helou et al., Göteborg, Sweden. In Oncogenesis, 2013
genomic region (ENPP2, FABP5, IMPAD1, NDRG1, PLEKHF2, RRM2B, SQLE, TAF2, TATDN1, TRPS1, VPS13B).
Microcephaly thin corpus callosum intellectual disability syndrome caused by mutated TAF2.
Basel-Vanagaite et al., Tel Aviv-Yafo, Israel. In Pediatr Neurol, 2013
RESULTS: We identified two homozygous missense changes, p.Thr186Arg and p.Pro416His in TAF2, which encodes a multisubunit cofactor for TFIID-dependent RNA polymerase II-mediated transcription, in all affected individuals.
Structural bioinformatics of the general transcription factor TFIID.
Review
Wyrwicz et al., Warsaw, Poland. In Biochimie, 2013
Despite numerous previous studies of the TFIID complex, the knowledge concerning the structure of its components, and thus the exact mechanism of its function, remains undetermined.
Microcephaly-thin corpus callosum syndrome maps to 8q23.2-q24.12.
Straussberg et al., Petah Tikva, Israel. In Pediatr Neurol, 2012
The candidate region includes 22 known or predicted genes, including RAD21, which is related to the cohesion complex EIF3H, which is involved in translation initiation, and TAF2, which may be involved in intellectual disability.
Genome-wide localization analysis of a complete set of Tafs reveals a specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters.
GeneRIF
Kokubo et al., Yokohama, Japan. In Nucleic Acids Res, 2010
a specific effect of a Taf1 mutation on Taf2 occupancy that may reflect the spatial relationship between Taf1 and Taf2 within TFIID
High-resolution transcription atlas of the mitotic cell cycle in budding yeast.
Steinmetz et al., Heidelberg, Germany. In Genome Biol, 2009
We detected periodic expression coupling of sense and antisense transcript pairs, including antisense transcripts opposite of key cell-cycle regulators, like FAR1 and TAF2.
TAFs and TFIIA mediate differential utilization of the tandem Adh promoters.
Impact
Tjian et al., Berkeley, United States. In Cell, 1995
Fractionation of this TBP-TAF complex reveals that TAFII150 is required for discrimination between the proximal and distal promoters.
Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II.
Impact
Tjian et al., Berkeley, United States. In Cell, 1995
A comparison of different partial TBP-TAF assemblages established that a trimeric TBP-TAFII250-TAFII150 complex is minimally required for efficient utilization of the initiator and downstream promoter elements.
Cellular mechanisms which distinguish between hormone- and antihormone-activated estrogen receptor.
Review
Stein et al., Durham, United States. In Ann N Y Acad Sci, 1995
These sequences, transactivation function 1 (TAF1) in the amino terminus and TAF2 at the carboxyl terminus, display distinct transcriptional functions.
Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators.
Impact
Tjian et al., Berkeley, United States. In Cell, 1994
We previously reported that transcriptional regulators can bind selected TAF subunits of the TFIID complex.
Drosophila TAFII150: similarity to yeast gene TSM-1 and specific binding to core promoter DNA.
Impact
Tjian et al., Berkeley, United States. In Science, 1994
Furthermore, like dTAFII150, the TSM-1 protein is found associated with the TBP in vivo, thus identifying the first yeast homolog of a TAF associated with TFIID.
Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation.
Impact
Tjian et al., Berkeley, United States. In Nature, 1993
This largest TAF may therefore play a central role in TFIID assembly by interacting with both TBP and other TAFs, as well as serving to link the control of transcription to the cell cycle.
Relationships of Agropyron intermedium chromosomes determined by chromosome pairing and alcohol dehydrogenase isozymes in common wheat background.
Zeller et al., Freising, Germany. In Theor Appl Genet, 1982
Chromosome pairing behaviour revealed that the alien chromosome in lines TAF-2 and L7 of 'Vilmorin'-A.
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