CD19 controls Toll-like receptor 9 responses in human B cells.
Konya, Turkey. In J Allergy Clin Immunol, Nov 2015
RESULTS: B cells from subjects with 1 or 2 defective CD19 alleles showed defective upregulation in vitro of CD86, transmembrane activator and CAML interactor (TACI), and CD23 activation markers after TLR9 stimulation.
Primary B cell immunodeficiencies: comparisons and contrasts.
Memphis, United States. In Annu Rev Immunol, 2008
Rare defects in ICOS or CD19 can result in a clinical picture that is consistent with common variable immunodeficiency, and as many as 10% of patients with this disorder have heterozygous amino acid substitutions in TACI.