gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tumor necrosis factor receptor superfamily, member 13B

TACI, TNFRSF13B, transmembrane activator and CAML interactor
The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: BR-3, CAML, HAD, CAN, IgA
Papers using TACI antibodies
Maturation of Marginal Zone and Follicular B Cells Requires B Cell Activating Factor of the Tumor Necrosis Factor Family and Is Independent of B Cell Maturation Antigen
Tschopp Jürg et al., In The Journal of Experimental Medicine, 1999
... cassette encoding the signal peptide of human Ig G heavy chain, the extracellular domain of human TACI (amino acids 2–118) or murine BCMA (amino acids 1–46) and the Fc domain of human Ig G1 was inserted in the transgenic vector using the EcoRI ...
Papers on TACI
Alterations in serotype-specific B cell responses to the 13-valent pneumococcal conjugate vaccine in aging HIV-infected adults.
Westerink et al., Toledo, United States. In Vaccine, Feb 2016
Transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI)(+) serotype-specific B cell percentages were significantly decreased in HIV+ PCV/PPV compared to PPV groups.
Participation of BAFF receptors in the pathogenesis of immune thrombocytopenia(ITP).
Shi et al., Jinan, China. In J Thromb Haemost, Feb 2016
BAFF and its receptors (BAFF-R, TACI, and BCMA) play central roles in the integrated homeostatic regulation of lymphocytes.
BAFF and its receptors involved in the inflammation progress in adjuvant induced arthritis rats.
Chang et al., Hefei, China. In Int Immunopharmacol, Jan 2016
In vivo, the levels of BAFF and the expression of BAFF-R, TACI were increased in spleen from very early stage of AA.
BAFF receptor and TACI in B-1b cell maintenance and antibacterial responses.
Alugupalli et al., Philadelphia, United States. In Ann N Y Acad Sci, Dec 2015
B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) mediate their function in mature B cells through the BAFF receptor (BAFFR) and transmembrane activator and CAML interactor (TACI).
BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.
Rawlings et al., Seattle, United States. In Curr Opin Immunol, Dec 2015
In this review, we highlight recent studies demonstrating the central role of the B cell antigen receptor (BCR), in coordination with other key pro-survival signals mediated by CD40, BAFF-R, TACI and/or TLRs, in regulating both negative and positive selection of autoreactive B cells.
CD19 controls Toll-like receptor 9 responses in human B cells.
Meffre et al., Konya, Turkey. In J Allergy Clin Immunol, Nov 2015
RESULTS: B cells from subjects with 1 or 2 defective CD19 alleles showed defective upregulation in vitro of CD86, transmembrane activator and CAML interactor (TACI), and CD23 activation markers after TLR9 stimulation.
Genetics of common variable immunodeficiency: role of transmembrane activator and calcium modulator and cyclophilin ligand interactor.
De Silva et al., Colombo, Sri Lanka. In Int J Immunogenet, Aug 2015
However, a number of distinct genetic defects including in inducible co-stimulator (ICOS), B-cell-activating factor receptor (BAFFR) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) have been identified in a minority of patients with CVID.
Blockade of B-cell activating factor with TACI-IgG effectively reduced Th1 and Th17 cells but not memory T cells in experimental allergic encephalomyelitis mice.
Wang et al., Beijing, China. In Cent Eur J Immunol, 2014
Along with other researchers, we have demonstrated that BAFF inhibitor atacicept (TACI-IgG) suppresses lupus and experimental allergic encephalomyelitis (EAE) by reducing the mature B-cell number but not memory B cells.
Effect of TACI signaling on humoral immunity and autoimmune diseases.
Tao et al., Wuhan, China. In J Immunol Res, 2014
Common variable immune deficiency (CVID) patients with heterozygous mutations in TACI alleles increase susceptibility to autoimmune diseases.
B-cell activating factor in the pathophysiology of multiple myeloma: a target for therapy?
Kersten et al., Amsterdam, Netherlands. In Blood Cancer J, 2014
Of these, only Transmembrane Activator and CAML Interactor (TACI) correlates with the MMC's capability to ligate BAFF.
IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.
Fillatreau et al., Berlin, Germany. In Nature, 2014
During Salmonella infection, IL-35- and IL-10-producing B cells corresponded to two largely distinct sets of surface-IgM(+)CD138(hi)TACI(+)CXCR4(+)CD1d(int)Tim1(int) plasma cells expressing the transcription factor Blimp1 (also known as Prdm1).
Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
Goldschmidt et al., United Kingdom. In Nat Genet, 2013
(rs4273077, TNFRSF13B, P = 7.67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10(-16)).
The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death.
Mackay et al., Melbourne, Australia. In Immunity, 2013
The transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) receptor and TLR4 cooperate to upregulate expression of both FasL and Fas on MZ B cells and also to repress inhibitors of Fas-induced apoptosis signaling.
The impact of TACI mutations: from hypogammaglobulinemia in infancy to autoimmunity in adulthood.
Di Matteo et al., Roma, Italy. In Int J Immunopathol Pharmacol, 2012
Data suggest a different impact of TACI mutations, from hypogammaglobulinemia in children to autoimmune disease in adulthood.
Immunological characteristics and two novel mutations in TACI in a cohort of 28 pediatric patients with common variable immunodeficiency.
Danielian et al., Buenos Aires, Argentina. In J Clin Immunol, 2012
the identification of two novel mutations in TNFRSF13B, including one, S231R, affecting the highly conserved THC domain
Rare mutations in TNFRSF13B increase the risk of asthma symptoms in Swedish children.
Hammarström et al., Huddinge, Sweden. In Genes Immun, 2012
We conclude that mutations in TACI are the contributing factors for asthma symptoms in Swedish children, although the mechanisms still remain elusive.
TACI deficiency impairs sustained Blimp-1 expression in B cells decreasing long-lived plasma cells in the bone marrow.
Cascalho et al., Ann Arbor, United States. In Blood, 2011
TACI promotes sustained Blimp-1 expression by B cells responding to antigen, which in turn limits B-cell clonal expansion and facilitates differentiation of long-lived antibody-secreting cells.
Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI.
Erikson et al., Philadelphia, United States. In J Clin Invest, 2011
Mice deficient in TACI, a receptor for BLyS and APRIL, mounted an initial antiviral B cell response similar to that generated in WT mice but failed to sustain protective Ab titers.
The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88.
Cerutti et al., New York City, United States. In Nat Immunol, 2010
MyD88 controls a B cell-intrinsic, TIR-independent, TACI-dependent pathway for immunoglobulin diversification
Primary B cell immunodeficiencies: comparisons and contrasts.
Campana et al., Memphis, United States. In Annu Rev Immunol, 2008
Rare defects in ICOS or CD19 can result in a clinical picture that is consistent with common variable immunodeficiency, and as many as 10% of patients with this disorder have heterozygous amino acid substitutions in TACI.
share on facebooktweetadd +1mail to friends