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ADAM metallopeptidase domain 17

TACE, ADAM17, TNF-alpha converting enzyme
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, metalloprotease, ADAM10, V1a, EGFR
Papers using TACE antibodies
A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC).
Supplier
Iijima Koichi M., In PLoS ONE, 2005
... The following antibodies were used: FLAG M2 (Sigma), HA.11 (Covance), ADAM10 (Calbiochem-422751), ADAM17 (Oncogene), APLP2 (Calbiochem-171617 and 171616) HRP-coupled anti-rabbit and anti-mouse (DAKO), HRP-coupled anti-rat (Santa Cruz), ...
Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing
Supplier
Nukina Nobuyuki et al., In The Journal of Cell Biology, 2001
... anti-X11, anti-X11L, anti-CASK, and anti-Munc18 (Transduction Laboratories); anti–Thy-1.2 (AbD Serotec and Invitrogen); anti-X11, anti-p35, and anti-ADAM17 (Santa Cruz Biotechnology, Inc.); rat anti-GFP (RQ2) ...
Differentiated structure and function of cultures from human tracheal epithelium.
Supplier
Rich Benjamin, In PLoS ONE, 1991
... Antibody directed against the cytoplasmic domain of tumor necrosis factor a-converting enzyme (TACE) was from Imgenex (San Diego, CA) ...
Papers on TACE
γ-secretase activity is required for regulated intramembrane proteolysis of tumor necrosis factor (TNF) receptor 1 and TNF-mediated pro-apoptotic signaling.
New
McCarthy et al., Cork, Ireland. In J Biol Chem, Feb 2016
In this study we show that following TNF-converting enzyme (TACE/ADAM17)-mediated ectodomain shedding of tumor necrosis factor (TNF) type I receptor (TNFR1), the membrane-bound TNFR1 C-terminal fragment (CTF) is subsequently cleaved by γ-secretase to generate a cytosolic TNFR1 intracellular domain (ICD).
Treatment of hepatocellular carcinoma: beyond international guidelines.
Review
New
Colombo et al., Milano, Italy. In Liver Int, Jan 2016
In patients with a large tumour burden such as those with intermediate stage BCLC B, repeated treatments with transarterial chemoembolization (TACE) are advocated with clinical benefits (from 16 to 22 months).
TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor.
New
Hiemstra et al., Leiden, Netherlands. In Respir Res, Dec 2015
Transactivation of EGFR by MSC-CM was investigated using a TACE inhibitor, and RT-PCR was used to quantify mRNA expression of several growth factors in MSCs and NCI-H292.
Inhibition of human hepatocellular carcinoma tumor angiogenesis by siRNA silencing of VEGF via hepatic artery perfusion.
New
Zhang et al., Hangzhou, China. In Eur Rev Med Pharmacol Sci, Dec 2015
Hepatic arterial chemoembolization transcatheter (TACE) is one of the main treatment methods for liver cancer.
PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.
New
Impact
Lapidot et al., Israel. In Nat Med, Nov 2015
Thrombin-PAR1 signaling induces nitric oxide (NO) production, leading to EPCR shedding mediated by tumor necrosis factor-α-converting enzyme (TACE), enhanced CXCL12-CXCR4-induced motility and rapid stem and progenitor cell mobilization.
Signalling in inflammatory skin disease by AP-1 (Fos/Jun).
Review
New
Wagner et al., Madrid, Spain. In Clin Exp Rheumatol, Jul 2015
In this GEMM and in psoriasis patient-derived material, S100A8/A9-dependent C3/CFB complement activation, as well as a miR-21-dependent TIMP-3/TACE pathway leading to TNF-α shedding, plays causal roles in disease development.
The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer's Disease.
Review
New
Wang et al., Hangzhou, China. In Cell Mol Neurobiol, Jul 2015
ADAM17 is supposed to be the regulated α-secretase of APP.
Recent advances in the field of anti-cancer immunotherapy.
Review
New
Kwok et al., Aomen, Macao. In Bba Clin, Jun 2015
We demonstrate three exciting targets for immunotherapy, TNF-α Converting Enzyme (TACE), Cathepsin S and Urokinase Plasmogen Activator and go over the advances made with one of the most used monoclonal antibodies in cancer therapy, Rituximab; as well as Herceptin, which is used for breast cancer therapy.
Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis.
New
Impact
Nagao et al., Bethesda, United States. In Immunity, May 2015
Herein, we demonstrate that Adam17(fl/fl)Sox9-(Cre) mice, generated to model ADAM17-deficiency in human, developed eczematous dermatitis with naturally occurring dysbiosis, similar to that observed in atopic dermatitis.
Effect of tissue inhibitor of metalloproteinases 3 on DLK1 shedding in cultured human pre-adipocytes and implications for adipose tissue remodelling.
New
Impact
Turner et al., Norwich, United Kingdom. In Lancet, Mar 2015
TIMP3 is known to inhibit ADAM17 (DLK1 sheddase) and MMP14 (implicated in extracellular matrix turnover).
Transmembrane Amyloid-Related Proteins in CSF as Potential Biomarkers for Alzheimer's Disease.
Review
Sáez-Valero et al., San Juan de Alicante, Spain. In Front Neurol, 2014
The enzymatic activities of some of these secretases, such as BACE1 and TACE, have been investigated as potential AD biomarkers, and it has been assumed that these activities present in human CSF result from the soluble truncated forms of the membrane-bound enzymes.
Therapeutic efficacy of brucea javanica oil emulsion (BJOE) combined with transcatheter hepatic arterial chemoembolization (TACE) in patients with primary liver cancer.
Zhao et al., Weifang, China. In Int J Clin Exp Med, 2014
This study is to investigate the effects of brucea javanica oil emulsion (BJOE) combined with transcatheter hepatic arterial chemoembolization (TACE) on primary liver cancer (PLC) and the related mechanisms.
Expression of MICA in oral squamous carcinoma cells and its effect on NK cells.
Liu et al., Fuzhou, China. In Int J Clin Exp Med, 2014
ADAM10 and ADAM17 were detected by ELISA method.
The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality.
Impact
Khokha et al., New Haven, United States. In Nature, 2014
GALNT11 O-glycosylates human NOTCH1 peptides in vitro, thereby supporting a mechanism of Notch activation either by increasing ADAM17-mediated ectodomain shedding of the Notch receptor or by modification of specific EGF repeats.
Alzheimer's and prion diseases: PDK1 at the crossroads.
Impact
Checler, Antibes, France. In Nat Med, 2013
TACE-mediated proteolysis is a key event interfering with both Alzheimer's and prion diseases.
MiR-222 modulates multidrug resistance in human colorectal carcinoma by down-regulating ADAM-17.
GeneRIF
Liu et al., Shanghai, China. In Exp Cell Res, 2012
Up-regulation of ADAM17 is associated with colorectal carcinoma.
Self-control of HGF regulation on human trophoblast cell invasion via enhancing c-Met receptor shedding by ADAM10 and ADAM17.
GeneRIF
Wang et al., Beijing, China. In J Clin Endocrinol Metab, 2012
HGF down-regulated c-Met receptor expression, whereas it up-regulated pro- and active/mature forms of ADAM10 and ADAM17 expression, which resulted in enhanced sMet production
Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17.
GeneRIF
Wagner et al., Madrid, Spain. In J Clin Invest, 2012
Epidermal Fos deletion in tumor models induced p53 expression. Epidermal cell differentiation and skin tumor suppression were caused by a p53-dependent transcriptional activation of the metalloprotease TACE.
The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells.
GeneRIF
Lee et al., Seoul, South Korea. In J Biol Chem, 2012
a novel role for PTK7 in the tumorigenesis via generation of PTK7-CTF2 by sequential cleavage of ADAM17 and gamma-secretase.
Role of ADAM10 and ADAM17 in CD16b shedding mediated by different stimulators.
GeneRIF
Zhang et al., Beijing, China. In Chin Med Sci J, 2012
Both ADAM10 and ADAM17 could shed CD16b, but they possess differed preferences. ADAM10 is the main sheddase under stimulation of ionomycin, while ADAM17 is the main sheddase under stimulation of PMA.
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