Signalling in inflammatory skin disease by AP-1 (Fos/Jun).
Madrid, Spain. In Clin Exp Rheumatol, Jul 2015
In this GEMM and in psoriasis patient-derived material, S100A8/A9-dependent C3/CFB complement activation, as well as a miR-21-dependent TIMP-3/TACE pathway leading to TNF-α shedding, plays causal roles in disease development.
Recent advances in the field of anti-cancer immunotherapy.
Aomen, Macao. In Bba Clin, Jun 2015
We demonstrate three exciting targets for immunotherapy, TNF-α Converting Enzyme (TACE), Cathepsin S and Urokinase Plasmogen Activator and go over the advances made with one of the most used monoclonal antibodies in cancer therapy, Rituximab; as well as Herceptin, which is used for breast cancer therapy.