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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Transforming, acidic coiled-coil containing protein 1

TACC1
This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: TACC3, CAN, FGFR1, TACC2, POLYMERASE
Papers on TACC1
Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma.
New
Ye et al., Seoul, South Korea. In Hepatology, Oct 2015
Long-term silencing of CD133 by a lentiviral-based approach inhibited cancer cell-cycle progression and suppressed in vivo tumorigenicity by down-regulating expression of cytokinesis-related genes, such as TACC1, ACF7, and CKAP5.
Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.
New
Lumey et al., Leiden, Netherlands. In Int J Epidemiol, Aug 2015
There was an increase in methylation of TACC1 and ZNF385A after exposure during any time in gestation (P < 2.0 × 10(-7), PFDR = 0.034) and a decrease of cg23989336 (TMEM105) after exposure around conception.
Xenopus TACC1 is a microtubule plus-end tracking protein that can regulate microtubule dynamics during embryonic development.
New
Lowery et al., Boston, United States. In Cytoskeleton (hoboken), May 2015
Here, we investigate the localization and function of Xenopus TACC1, the founding member of the TACC family.
Comprehensive analysis of targetable oncogenic mutations in chinese cervical cancers.
New
Yang et al., Shanghai, China. In Oncotarget, Apr 2015
No mutations were detected in AKT1 or BRAF, and the fusions FGFR1-TACC1, EML4-ALK, CCDC6-RET and KIF5B-RET were not found in any of the cancers.
Expression status of candidate genes in mesothelioma tissues and cell lines.
Landi et al., Pisa, Italy. In Mutat Res, 2015
Nine genes (ACSL1, CCNO, CFB, PDGFRB, SULF1, TACC1, THBS2, TIMP3, XPOT) were deregulated with statistical significance in both cell lines, 12 (ASS1, CCNB1, CDH11, COL1A1, CXADR, EIF4G1, GALNT7, ITGA4, KRT5, PTGIS, RAN, SOD1) in at least one cell line, whereas 7 (DSP, HEG1, MCM4, MSLN, NME2, NMU, TNPO2) were close but did not reach the statistical significance in any of the cell line.
Prognosis significance of HER2 status and TACC1 expression in patients with gastric carcinoma.
Yue et al., Qingdao, China. In Med Oncol, 2014
The dysregulation of transforming acidic coiled coil 1 (TACC1), a downstream gene of HER2, is thought to be involved in the development of GC.
Expression pattern of an evolutionarily conserved splice variant in the rat Tacc2 gene.
Sinha et al., Ottawa, Canada. In Genesis, 2014
The transforming acidic coiled-coil containing protein 2 (Tacc2) gene and its paralogs, Tacc1 and Tacc3 encode proteins that are associated with the centrosome and involved in microtubule assembly during the cell cycle.
Molecular contribution to cleft palate production in cleft lip mice.
Fujiwara et al., Yokohama, Japan. In Congenit Anom (kyoto), 2014
Four candidate genes (Ywhab, Nek2, Tacc1 and Frk) were linked in a gene network that associates with cell proliferation (cell cycle, MAPK, Wnt and Tgf beta pathways).
FGF receptors: cancer biology and therapeutics.
Review
Nakagama et al., Tokyo, Japan. In Med Res Rev, 2014
FGFR1 and FGFR3 genes are fused to neighboring TACC1 and TACC3 genes, respectively, due to interstitial deletions in glioblastoma multiforme.
Repeats in transforming acidic coiled-coil (TACC) genes.
Trivedi, Jodhpur, India. In Biochem Genet, 2013
Transforming acidic coiled-coil proteins (TACC1, 2, and 3) are essential proteins associated with the assembly of spindle microtubules and maintenance of bipolarity.
Efficient downregulation of ErbB-2 induces TACC1 upregulation in breast cancer cell lines.
Yue et al., Qingdao, China. In Oncol Rep, 2013
Dysregulation of the human transforming acidic coiled-coil 1 (TACC1) and ErbB-2 genes is thought to be important in the development and progression of breast cancer.
Impact of NPM, TFF3 and TACC1 on the prognosis of patients with primary gastric cancer.
Qiu et al., Qingdao, China. In Plos One, 2012
BACKGROUND: NPM, TFF3 and TACC1 are molecular markers that play important roles in cell differentiation.
Transforming fusions of FGFR and TACC genes in human glioblastoma.
Impact
GeneRIF
Iavarone et al., New York City, United States. In Science, 2012
study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor genes(FGFR1 or FGFR3) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3; the FGFR-TACC fusion protein displays oncogenic activity
A landscape of driver mutations in melanoma.
Impact
Chin et al., Cambridge, United States. In Cell, 2012
Analysis of large-scale melanoma exome data by this approach discovered six novel melanoma genes (PPP6C, RAC1, SNX31, TACC1, STK19, and ARID2), three of which-RAC1, PPP6C, and STK19-harbored recurrent and potentially targetable mutations.
Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein.
GeneRIF
Arlot-Bonnemains et al., Rennes, France. In Biochem Biophys Res Commun, 2011
the study demonstrated that TACC1 localizes at the midbody during cytokinesis and interacts with and is a substrate of Aurora-C, which warrant further investigation in order to elucidate the functional significance of this interaction.
The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.
GeneRIF
Ravel-Chapuis et al., Lyon, France. In Bmc Mol Biol, 2009
TACC1 depletion in the cell led to decreased RARalpha and TRalpha ligand-dependent transcriptional activity and to delocalization of TR from the nucleus to the cytoplasm.
Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer.
GeneRIF
Cohen et al., Lyon, France. In J Mol Endocrinol, 2009
TACC1 and a three-gene expression signature (TACC1, NOV, and PTTG1) were identified as independent prognostic markers.
Temporal and spatial expression of TACC1 in the mouse and human.
GeneRIF
Still et al., Buffalo, United States. In Dev Dyn, 2006
Splice variants can be localized to different subcellular compartments in a cell-and tissue-specific manner.
AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains.
Review
GeneRIF
Maxwell et al., Belfast, United Kingdom. In Leuk Lymphoma, 2002
REVIEW: genetics, expression, gene expression regulation, and function studies
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