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CD3d molecule, delta

T3D, CD3 delta, CD3D
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: CD3 gamma, CAN, CD3epsilon, T1L, CD8
Papers on T3D
Aberrant DNA methylation impacts gene expression and prognosis in breast cancer subtypes.
Review
New
Santarpia et al., Budapest, Hungary. In Int J Cancer, Feb 2016
The expression of several immune-related genes, including CD3D and HLA-A, was associated with both relapse-free survival (HR = 0.42, p = 3.5E-06; HR = 0.35, p = 1.7E-08) and overall survival (HR = 0.50, p = 5.5E-04; HR = 0.68, p = 4.5E-02) in ER-/HER2- BCs.
Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion.
New
Coombs et al., Winnipeg, Canada. In J Virol, Jan 2016
We recently performed global proteomic screens of mammalian reovirus TIL- and T3D-infected and herpesvirus (herpes simplex virus 1 [HSV-1])-infected HEK293 cells.
Effect of dexmedetomidine on the QT interval in pediatric patients undergoing general anesthesia.
New
Tobias et al., Columbus, United States. In J Anesth, Dec 2015
In group D, the third ECG was obtained 2 min after the administration of dexmedetomidine, which in turn was started immediately after the T2 ECG reading (T3D); in group C, it was obtained 2 min after the T2 reading (T3C).
Self-assembly formed by a short DNA probe pair: Application for highly sensitive mRNA species detection without reverse transcription.
New
Takei et al., Japan. In Biochem Biophys Res Commun, Dec 2015
We prepared pairs of HCPs to detect mRNAs encoded by the GAPDH gene β-actin (BA) gene, CD3D gene, CD4 gene, major vault protein (MV) gene and the signalling lymphocytic activation molecule-associated protein (SAP) gene, and succeeded in quantitatively detecting these mRNAs.
Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling.
New
Peterson et al., Tartu, Estonia. In J Autoimmun, Nov 2015
Among the hypermethylated CpG sites, we specifically found enrichment of genes involved in T cell signaling (CD247, LCK, ZAP70, CD3D, CD3E, CD3G, CTLA4 and CD8A) and decreased expression of CD3 gene family members.
Anti-cancer effects of oncolytic viral therapy combined with photodynamic therapy in human pancreatic cancer cell lines.
New
Impact
Jayne et al., Leeds, United Kingdom. In Lancet, Mar 2015
METHODS: Pancreatic cancer cell lines (PsPC-1 and BXPC-3) and a non-cancer control cell line (HEK293) were infected with reovirus serotype 3 strain Dearing (T3D) at 0, 0·1, 1, and 10 plaque-forming units (PFU) per cell for 48 h.
A Panel of Genetic Polymorphism for the Prediction of Prognosis in Patients with Early Stage Non-Small Cell Lung Cancer after Surgical Resection.
Park et al., Taegu, South Korea. In Plos One, 2014
RESULTS: The eight SNPs (CD3EAP rs967591, TNFRSF10B rs1047266, AKT1 rs3803300, C3 rs2287845, HOMER2 rs1256428, GNB2L1 rs3756585, ADAMTSL3 rs11259927, and CD3D rs3181259) were significantly associated with OS and/or DFS.
Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia.
GeneRIF
Li et al., Guangzhou, China. In J Hematol Oncol, 2011
Altered expression of the TCR signaling related genes CD3 and FcepsilonRIgamma in patients with aplastic anemia.
Epidermal CCR6+ γδ T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis.
GeneRIF
Hwang et al., Milwaukee, United States. In J Immunol, 2011
A transgenic T cell receptor gammadelta-low expressing subset of T cells accumulates in mouse ear keratinocytes after IL-23 injections.
A leaky mutation in CD3D differentially affects αβ and γδ T cells and leads to a Tαβ-Tγδ+B+NK+ human SCID.
GeneRIF
Regueiro et al., Madrid, Spain. In J Clin Invest, 2011
report 2 unrelated cases of SCID with a selective block in alphabeta but not in gammadelta T cell development, associated with a new splicing mutation in the CD3D gene
Stimulated γδ T cells increase the in vivo efficacy of trastuzumab in HER-2+ breast cancer.
GeneRIF
Fournié et al., Toulouse, France. In J Immunol, 2011
A combination of trastuzumab antibody and phosphoantigen-stimulated gammadelta T-lymphocytes increases the efficacy of trastuzumab alone against HER-2-positive breast carcinoma cell lines in vivo and mammary carcinoma xenografts in mice.
The expression pattern of CD3 chain genes in fetal/maternal interface.
GeneRIF
Li et al., Guangzhou, China. In Hematology, 2011
Study characterized the expression pattern of CD3-gamma, -delta, -epsilon and -zeta chain genes from placenta, which contributes to further understanding of the features of T-cell immune status in placenta.
Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer.
Impact
von Minckwitz et al., Berlin, Germany. In J Clin Oncol, 2010
The expression of inflammatory marker genes and proteins was linked to the histopathologic infiltrate, and logistic regression showed a significant association of the T-cell-related markers CD3D and CXCL9 with pCR.
Modification of mammalian reoviruses for use as oncolytic agents.
Review
Hoeben et al., Leiden, Netherlands. In Expert Opin Biol Ther, 2009
One of these, human reovirus type 3 Dearing (T3D), usually serves as a model for the family.
A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation.
Impact
Wang et al., Yokohama, Japan. In Immunity, 2008
We demonstrate that the lysosomal protein LAPTM5 negatively regulated surface TCR expression by specifically interacting with the invariant signal-transducing CD3zeta chain and promoting its degradation without affecting other CD3 proteins, CD3epsilon, CD3delta, or CD3gamma.
[Expression anomalies of the CD3-TCR complex expression and immunodeficiencies].
Review
Fischer et al., Montréal, Canada. In Med Sci (paris), 2007
The main differences observed involve the respective roles of the CD3gamma chain as well as the CD3delta, whose functions seem to be reciprocal between the two species.
Human T cell immunodeficiency: when signal transduction goes wrong.
Review
Roifman et al., Toronto, Canada. In Immunol Res, 2005
Among these discoveries, we described the first mutated signal transduction protein in T cells (ZAP-70); the first genetic defect leading to SCID and autoimmune phenomena (IL2R alpha); and, recently, the critical importance of CD3delta in the development of T cells.
CD3 deficiencies.
Review
Le Deist et al., Paris, France. In Curr Opin Allergy Clin Immunol, 2005
RECENT FINDINGS: Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.
Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution.
Review
Impact
Buckley, Durham, United States. In Annu Rev Immunol, 2003
Additionally, a deficiency of CD3 delta, a component of the T-cell antigen receptor, results in a near absence of circulating mature CD3+ T cells and a complete lack of gamma/delta T cells.
Distinct structure and signaling potential of the gamma delta TCR complex.
Impact
Love et al., Bethesda, United States. In Immunity, 2002
Here, we report that, unlike alpha beta T CRs, most gamma delta TCRs expressed on ex vivo gamma delta T cells lack CD3 delta.
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