Human T cell immunodeficiency: when signal transduction goes wrong.
Toronto, Canada. In Immunol Res, 2005
Among these discoveries, we described the first mutated signal transduction protein in T cells (ZAP-70); the first genetic defect leading to SCID and autoimmune phenomena (IL2R alpha); and, recently, the critical importance of CD3delta in the development of T cells.
Paris, France. In Curr Opin Allergy Clin Immunol, 2005
RECENT FINDINGS: Homozygous mutations in CD3D and CD3E genes lead to a complete block in T-cell development and thus to an early-onset severe combined immunodeficiency phenotype.