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Taste receptor, type 2, member 3

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: STEP, SET, ACID, hTAS2R16, POLYMERASE
Papers on T2R3
Identification of novel genes for bitter taste receptors in sheep (Ovis aries).
Almeida et al., √Čvora, Portugal. In Animal, 2013
In sheep, we identified eight orthologs of cattle genes: T2R16, T2R10B, T2R12, T2R3, T2R4, T2R67, T2R13 and T2R5.
Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues.
Ikeda et al., Tokyo, Japan. In Ann Otol Rhinol Laryngol, 2012
Our results show that the expression rate of some of the T2R taste receptor genes was increased significantly in patients with phantogeusia.
Patients with hypogeusia show changes in expression of T2R taste receptor genes in their tongues.
Ikeda et al., Tokyo, Japan. In Laryngoscope, 2011
The expression of 10 T2R genes (TAS2R40, -R42, -R43, and -R48, and T2R3, -R8, -R9, -R10, -R13, and -R16) was evaluated by reverse transcriptase-polymerase chain reaction.
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
Mootha et al., Cambridge, United States. In Proc Natl Acad Sci U S A, 2009
Includes the study of a polymorphic upstream ORF in this gene, and shows that it functions to reduce protein levels by ~58%.
A balanced reciprocal translocation t(5;7)(q14;q32) associated with autistic disorder: molecular analysis of the chromosome 7 breakpoint.
Dahl et al., Uppsala, Sweden. In Am J Med Genet, 2002
Mutation screening of the genes SSBP and T2R3 located just centromeric to the breakpoint was performed in a set of 29 unrelated autistic sibling pairs who shared at least one chromosome 7 haplotype.
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