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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Taste receptor, type 2, member 3

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on T2R3
Patients with phantogeusia show increased expression of T2R taste receptor genes in their tongues.
Ikeda et al., Tokyo, Japan. In Ann Otol Rhinol Laryngol, 2012
Our results show that the expression rate of some of the T2R taste receptor genes was increased significantly in patients with phantogeusia.
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
Mootha et al., Cambridge, United States. In Proc Natl Acad Sci U S A, 2009
Includes the study of a polymorphic upstream ORF in this gene, and shows that it functions to reduce protein levels by ~58%.
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