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Taste receptor, type 2, member 1

T2R1, TAS2R1, hTAS2R1
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TAS2R38, GPCR, hTAS2R16, SET, Sema5A
Papers on T2R1
Bitter taste receptor T2R1 activities were compatible with behavioral sensitivity to bitterness in chickens.
Tabata et al., Fukuoka, Japan. In Biochem Biophys Res Commun, Jun 2015
We cloned one of the bitter taste receptors, T2R1, from the chicken palate, constructed several biosensor-cells expressing chicken T2R1 (cT2R1), and determined a highly sensitive biosensor of cT2R1 among them.
Amarogentin Displays Immunomodulatory Effects in Human Mast Cells and Keratinocytes.
Schempp et al., Freiburg, Germany. In Mediators Inflamm, 2014
Keratinocytes express the bitter taste receptors TAS2R1 and TAS2R38.
Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.
Schempp et al., Freiburg, Germany. In Skin Pharmacol Physiol, 2014
Here, we show for the first time the expression of TAS2R1 and TAS2R38 in human skin.
Differential expression of bitter taste receptors in non-cancerous breast epithelial and breast cancer cells.
Chelikani et al., Winnipeg, Canada. In Biochem Biophys Res Commun, 2014
In this report using quantitative (q)-PCR and flow cytometry, we characterized the expression of T2R1, T2R4, T2R10, T2R38 and T2R49 in the highly metastatic breast cancer cell line MDA-MB-231, poorly metastatic cell line MCF-7, and non-cancerous mammary epithelial cell line MCF-10A.
Dextromethorphan mediated bitter taste receptor activation in the pulmonary circuit causes vasoconstriction.
Chelikani et al., Winnipeg, Canada. In Plos One, 2013
Previously in site-directed mutational studies, we have characterized the response of T2R1 to dextromethorphan, therefore, T2R1 was selected for further analysis in this study.
Amino acids and peptides activate at least five members of the human bitter taste receptor family.
Meyerhof et al., Potsdam, Germany. In J Agric Food Chem, 2013
L-Phenylalanine and L-tryptophan activate TAS2R1 and TAS2R4, respectively, whereas TAS2R4 and TAS2R39 responded to D-tryptophan.
Assessment of the presence of chemosensing receptors based on bitter and fat taste in the gastrointestinal tract of young pig.
Bosi et al., Reggio nell'Emilia, Italy. In J Anim Sci, 2012
For 7 genes for bitter taste (TAS2R1, TAS2R3, TAS2R7, TAS2R9, TAS2R10, TAS2R16, and TAS2R38) and for 3 genes for fat taste (GPR40, GPR43, and GPR120), a full homology for exon sequences was found and primers were designed by Primer3.
Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem.
Jayam-Trouth et al., Washington, D.C., United States. In Brain Res, 2012
Presence of the T2R1 gene and other genes and proteins of the bitter taste transduction pathway in the brainstem implies additional functions for taste receptors and their effector molecules apart from their gustatory function.
TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis.
Liggett et al., Baltimore, United States. In Am J Physiol Lung Cell Mol Physiol, 2012
Intracellular signaling and cell mechanics using isolated human airway smooth muscle, mouse tracheal responses, and human bronchial responses to characterize TAS2R relaxation in the context of beta(2)AR desensitization.
The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families.
Italian Autism Network (ITAN) et al., Verona, Italy. In Psychiatr Genet, 2012
METHODS: We have genotyped 746 individuals from 227 families of the Italian Autism Network using allelic discrimination TaqMan assays for seven common single-nucleotide polymorphisms: rs2292813 (SLC25A12 gene), rs35678 (ATP2B2 gene), rs4307059 (between CDH9 and CDH10 genes), rs10513025 (between SEMA5A and TAS2R1 genes), rs6872664 (PITX1 gene), rs1861972 (EN2 gene), and rs4141463 (MACROD2 gene).
Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).
Chelikani et al., Winnipeg, Canada. In J Biol Chem, 2011
Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs).
Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies.
Hu et al., Nanjing, China. In J Recept Signal Transduct Res, 2011
The formation of a short helical segment in intracellular loop II may be necessary for the activation of hTAS2R1.
Transanal endoscopic microsurgery (TEM) for rectal tumor: the first French single-center experience.
Panis et al., Clichy, France. In Gastroenterol Clin Biol, 2010
Immediate salvage surgery was performed in one patient because of a T2R1 carcinoma.
Bitter taste receptor T2R1 is activated by dipeptides and tripeptides.
Chelikani et al., Winnipeg, Canada. In Biochem Biophys Res Commun, 2010
The ligand binding pocket in T2R1 is present on the extracellular surface of the receptor, and is formed by the transmembrane helices 1, 2, 3 and 7 and with extracellular loops 1 and 2 forming a cap like structure on the binding pocket.
A genome-wide linkage and association scan reveals novel loci for autism.
Chakravarti et al., Boston, United States. In Nature, 2009
Initial analysis did not yield genome-wide significant associations; however, genotyping of top hits in additional families revealed an SNP on chromosome 5p15 (between SEMA5A and TAS2R1) that was significantly associated with autism (P = 2 x 10(-7)).
[Comparative genetic analysis of different forms of low-renin arterial hypertension].
Favorova et al., In Mol Biol (mosk), 2008
The analysis of carriership of the alleles and genotypes combinations of the polymorphous regions has shown that genes CYP11B2, REN, ACE, CMA andA T2R1 participate in development of low-renin HA.
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