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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Taste receptor, type 1, member 2

T1R2, TAS1R2, TR-2
mouse Nr2c1 exhibits transcription factor, subtilase, ligand-dependent nuclear receptor and steroid hormone activities [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, ACID, TIR1, HAD, Insulin
Papers using T1R2 antibodies
The receptors for mammalian sweet and umami taste
Supplier
de Araujo Ivan E. et al., In Frontiers in Integrative Neuroscience, 2002
... Tas1r2 and Tas1r3 from mouse cortex were purified using the QIAquick PCR Purification Kit (Qiagen), ligated into the pDrive ...
Papers on T1R2
Arecoline Alters Taste Bud Cell Morphology, Reduces Body Weight, and Induces Behavioral Preference Changes in Gustatory Discrimination in C57BL/6 Mice.
New
Kung et al., Taipei, Taiwan. In Chem Senses, Jan 2016
After arecoline treatment, the vallate papillae were processed for electron microscopy and immunohistochemistry analysis of taste receptor proteins (T1R2, T1R3, T1R1, and T2R) and taste associated proteins (α-gustducin, PLCβ2, and SNAP25).
Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor.
New
Max et al., New York City, United States. In Chem Senses, Oct 2015
The sweet taste receptor, a heterodimeric G protein-coupled receptor comprised of T1R2 and T1R3, binds sugars, small molecule sweeteners, and sweet proteins to multiple binding sites.
Effects of chemotherapy on gene expression of lingual taste receptors in patients with head and neck cancer.
New
Takeda et al., Tokushima, Japan. In Laryngoscope, Oct 2015
The messenger RNA (mRNA) levels of the taste receptor subunits T1R1, T1R2, T1R3, and T2R5 were measured in lingual mucosa scrapings obtained with a small spatula.
Polymorphisms in sweet taste genes (TAS1R2 and GLUT2), sweet liking, and dental caries prevalence in an adult Italian population.
New
Navarra et al., Trieste, Italy. In Genes Nutr, Sep 2015
Our study confirmed that polymorphisms in TAS1R2 and GLUT2 genes are related to DMFT index.
Return of the glucoreceptor: Glucose activates the glucose-sensing receptor T1R3 and facilitates metabolism in pancreatic β-cells.
Review
New
Nagasawa et al., Maebashi, Japan. In J Diabetes Investig, May 2015
Subunits of the sweet taste receptor, namely T1R2 and T1R3, are expressed in mouse pancreatic islets.
Variation in the TAS1R2 Gene, Sweet Taste Perception and Intake of Sugars.
El-Sohemy et al., Toronto, Canada. In J Nutrigenet Nutrigenomics, 2014
BACKGROUND/AIMS: To determine whether variation in the TAS1R2 gene affects sucrose taste perception and sugar intake.
Sinonasal solitary chemosensory cells "taste" the upper respiratory environment to regulate innate immunity.
Review
Cohen et al., Philadelphia, United States. In Am J Rhinol Allergy, 2014
RESULTS: Human sinonasal SCCs express both bitter T2R and sweet T1R2/3 receptors.
Sensory biology. Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor.
Impact
Liberles et al., Cambridge, United States. In Science, 2014
We observed the widespread absence in birds of an essential subunit (T1R2) of the only known vertebrate sweet receptor, raising questions about how specialized nectar feeders such as hummingbirds sense sugars.
Functional roles of the sweet taste receptor in oral and extraoral tissues.
Review
Briand et al., Dijon, France. In Curr Opin Clin Nutr Metab Care, 2014
SUMMARY: The perception of sweet taste is mediated by the T1R2/T1R3 receptor, which is expressed in the oral cavity, wherein it provides input on the caloric and macronutrient contents of ingested food.
Sweet Taste-Sensing Receptors Expressed in Pancreatic β-Cells: Sweet Molecules Act as Biased Agonists.
Review
Nagasawa et al., Maebashi, Japan. In Endocrinol Metab (seoul), 2014
The sweet taste receptors present in the taste buds are heterodimers comprised of T1R2 and T1R3.
Structure, function, and signaling of taste G-protein-coupled receptors.
Review
Ninomiya et al., Fukuoka, Japan. In Curr Pharm Biotechnol, 2013
TAS1Rs which belong to class C G-protein-coupled receptors form heterodimeric complexes to function as sweet (TAS1R2 + TAS1R3) or umami (TAS1R1 + TAS1R3) taste receptors.
Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal.
GeneRIF
Spector et al., Tallahassee, United States. In Am J Physiol Regul Integr Comp Physiol, 2012
T1R2+3 heterodimer is the principal receptor that mediates taste detection of natural sweeteners, but not of all carbohydrate stimuli.
Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion.
GeneRIF
Tyrberg et al., Orlando, United States. In Proc Natl Acad Sci U S A, 2012
Genetic ablation of the sweet TR protein T1R2 obliterates fructose-induced insulin release and its potentiating effects on glucose-stimulated insulin secretion in vitro and in vivo.
Behavioral evidence for a glucose polymer taste receptor that is independent of the T1R2+3 heterodimer in a mouse model.
GeneRIF
Spector et al., Tallahassee, United States. In J Neurosci, 2011
the present study provides behavioral evidence for the presence of a glucose polymer taste receptor that is independent of the T1R2+3 heterodimer.
The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.
GeneRIF
Beglinger et al., Basel, Switzerland. In Am J Physiol Endocrinol Metab, 2011
T1R2/T1R3 is involved in glucose-dependent secretion of satiation peptides
Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations.
GeneRIF
El-Sohemy et al., Toronto, Canada. In Am J Clin Nutr, 2010
Our findings show that a genetic variation in TAS1R2 affects habitual consumption of sugars and may contribute to interindividual differences in changing behaviors in response to dietary counseling.
A TAS1R receptor-based explanation of sweet 'water-taste'.
Impact
GeneRIF
Breslin et al., Philadelphia, United States. In Nature, 2006
water rinses remove the inhibitor from the heteromeric sweetener receptor TAS1R2-TAS1R3, which activates cells and results in the perception of strong sweetness from pure water
The receptors for mammalian sweet and umami taste.
Impact
GeneRIF
Zuker et al., San Diego, United States. In Cell, 2003
sweet and umami taste are strictly dependent on T1R-receptors, and show that selective elimination of T1R-subunits differentially abolishes detection and perception of these two taste modalities
Detection of sweet and umami taste in the absence of taste receptor T1r3.
Impact
Margolskee et al., New York City, United States. In Science, 2003
Molecular genetics and heterologous expression implicate T1r2 plus T1r3 as a sweet-responsive receptor,and T1r1 plus T1r3,as well as a truncated form of the type 4 metabotropic glutamate receptor (taste-mGluR4),as umami-responsive receptors.
Mammalian sweet taste receptors.
Impact
Zuker et al., San Diego, United States. In Cell, 2001
Second, using a heterologous expression system, we demonstrate that T1R2 and T1R3 combine to function as a sweet receptor, recognizing sweet-tasting molecules as diverse as sucrose, saccharin, dulcin, and acesulfame-K.
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