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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

LAG1 homolog, ceramide synthase 6

T1L, LASS6, CerS6
Top mentioned proteins: T3D, ACID, LAG1, CAN, V1a
Papers on T1L
Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner.
New
Krupenko et al., Chapel Hill, United States. In Plos One, Dec 2015
We previously reported that ceramide synthase 6 (CerS6) is elevated in response to folate stress in cancer cells, leading to enhanced production of C16-ceramide and apoptosis.
SIRT3 Deacetylates Ceramide Synthases: Implications for Mitochondrial Dysfunction and Brain Injury.
New
Gudz et al., United States. In J Biol Chem, Dec 2015
Reciprocal immunoprecipitation experiments revealed that CerS1, CerS2 and CerS6, but not CerS4, are associated with SIRT3 in cerebral mitochondria.
Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.
New
Obeid et al., New York City, United States. In J Biol Chem, Nov 2015
Ceramide synthases (CerS1-CerS6), which catalyze the N-acylation of the (dihydro)sphingosine backbone to produce (dihydro)ceramide in both the de novo and the salvage or recycling pathway of ceramide generation, have been implicated in the control of programmed cell death.
Viral gene expression potentiates reovirus-induced necrosis.
New
Danthi et al., Bloomington, United States. In Virology, Oct 2015
While reovirus strain T3D induces necrosis much more efficiently than strain T1L, which viral components contribute to this difference is not known.
By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, stichoposide D inhibits growth of leukemia xenografts.
New
Park et al., Pusan, South Korea. In Oncotarget, Oct 2015
The role of Fas (CD95), ceramide synthase 6 (CerS6) and p38 kinase during STD-induced apoptosis was examined in human leukemia cells.
Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide.
New
Zhang et al., Beijing, China. In J Ethnopharmacol, Aug 2015
Several enzymes, including kdsr, CerS2, CerS4, CerS5 and CerS6 in the liver and Cerk in the kidney were probably responsible for the TP-induced toxic effect, identifying them as possible novel therapeutic targets.
Endocannabinoid and ceramide levels are altered in patients with colorectal cancer.
New
Ren et al., Xiamen, China. In Oncol Rep, Jul 2015
Levels of two enzymes participating in the biosynthesis and degradation of AEA, N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NPLD) and fatty acid amide hydrolase (FAAH), together with the most abundant ceramide synthases (CerS1, CerS2, CerS5 and CerS6) in the colon were also determined.
Comparative proteomic analyses of two reovirus T3D subtypes and comparison to T1L identifies multiple novel proteins in key cellular pathogenic pathways.
New
Coombs et al., Winnipeg, Canada. In Proteomics, Jun 2015
We previously used SILAC to examine host proteomic changes in protein abundance in HEK293 cells infected with reovirus type 1, strain Lang (T1L).
Comparative proteomic analyses demonstrate enhanced interferon and STAT-1 activation in reovirus T3D-infected HeLa cells.
Coombs et al., Winnipeg, Canada. In Front Cell Infect Microbiol, 2014
Triplicate replicates of cytosolic and nuclear fractions identified a total of 2375 proteins, of which 50, 57, and 46 were significantly up-regulated, and 37, 26, and 44 were significantly down-regulated by T1L, T3D, and UV-T3D, respectively.
Association between CLN3 (Neuronal Ceroid Lipofuscinosis, CLN3 Type) Gene Expression and Clinical Characteristics of Breast Cancer Patients.
Boustany et al., Beirut, Lebanon. In Front Oncol, 2014
Sphingolipid genes for ceramide synthases 2 and 6 (CerS2; CerS6), delta(4)-desaturase sphingolipid 2 (DEGS2), and acidic sphingomyelinase (SMPD1) displayed higher expression levels in breast cancer vs. control tissue, whereas ceramide galactosyltransferase (UGT8) was underexpressed in breast cancer samples.
CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.
Impact
Summers et al., Singapore, Singapore. In Cell Metab, 2014
Inhibiting global ceramide synthesis negated the effects of CerS2 haploinsufficiency in vivo, and increasing C16-ceramides by overexpressing CerS6 recapitulated the phenotype in isolated, primary hepatocytes.
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
Impact
Brüning et al., Köln, Germany. In Cell Metab, 2014
Here we reveal that CERS6 mRNA expression and C16:0 ceramides are elevated in adipose tissue of obese humans, and increased CERS6 expression correlates with insulin resistance.
Diverse functions of ceramide in cancer cell death and proliferation.
Review
Ogretmen et al., Charleston, United States. In Adv Cancer Res, 2012
For example, different fatty-acid chain lengths of ceramide, such as C(16)-ceramide that can be generated by ceramide synthase 6 (CerS6), have been implicated in cancer cell proliferation, whereas CerS1-generated C(18)-ceramide mediates cell death.
Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis.
GeneRIF
Geisslinger et al., Frankfurt am Main, Germany. In J Immunol, 2012
The transiently increased expression of ceramide synthase (CerS6) correlates to the clinical finding that C(16:0)-Cer levels are increased 1.9-fold in cerebrospinal fluid of multiple sclerosis patients.
Ceramide synthases at the centre of sphingolipid metabolism and biology.
Review
Obeid et al., Charleston, United States. In Biochem J, 2012
Six mammalian CerSs (CerS1-CerS6) have been identified.
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network.
GeneRIF
Ogretmen et al., Charleston, United States. In J Biol Chem, 2012
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network
Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.
GeneRIF
Kolesnick et al., New York City, United States. In Cell Signal, 2010
ionizing radiation induces de novo synthesis of ceramide to influence HeLa cell apoptosis by specifically activating CerS isoforms 2, 5, and 6 that generate opposing anti- and pro-apoptotic ceramides in mitochondrial membranes.
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
GeneRIF
Dent et al., Richmond, United States. In Cancer Res, 2010
Findings indicate that mda-7/IL-24 induces PERK activation that triggers production of ceramide, ceramide synthase 6 and thioredoxin, which in turn promote glioma cell autophagy and cell death.
Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.
GeneRIF
Futerman et al., Israel. In Biochem Biophys Res Commun, 2010
CerS2 and CerS6 mRNA was significantly elevated in breast cancer tissue compared to paired normal tissue, with approximately half of the individuals showing elevated CerS2 and CerS6 mRNA.
Ceramide biosynthesis in keratinocyte and its role in skin function.
Review
Igarashi et al., Sapporo, Japan. In Biochimie, 2009
We also describe recent studies that identified the family of CerS (CerS1-CerS6) in mammals.
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