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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

T-box 21

T-bet, T-box transcription factor, TBX21
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: BET, GATA3, TH2, CD4, CAN
Papers using T-bet antibodies
Regulatory CD56bright natural killer cells mediate immunoregulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis.
Supplier
Reindl Markus, In PLoS ONE, 2005
... FITC-conjugated mouse anti-IL-17A, APC-conjugated anti-IL17, PE-conjugated rat anti-RORγt, PE-conjugated rat anti-T-bet, mouse and rat IgG isotype controls were purchased from eBioscience (San Diego, CA, USA) ...
Beta and gamma oscillations in the olfactory system of the urethane-anesthetized rat
Supplier
Yoshihara Yoshihiro et al., In Neural Systems & Circuits, 2002
... Summary of gapVenus expression in Tbx21 transgenic mice ...
Papers on T-bet
Complementarity and redundancy of IL-22-producing innate lymphoid cells.
New
Impact
Vivier et al., Melbourne, Australia. In Nat Immunol, Feb 2016
We identified here the transcriptional signature associated with the transcription factor T-bet-dependent differentiation of NCR(-) ILC3 cells into NCR(+) ILC3 cells.
Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment.
New
Impact
Zhu et al., Bethesda, United States. In Nat Immunol, Feb 2016
In addition, GATA-3 served a critical function in the development of the NKp46(+) ILC3 subset by regulating the balance between the transcription factors T-bet and RORγt.
Identification of a Th2 and Th17 Skewed Immune Phenotype in Chronic Urticaria with Th22 Reduction Dependent on Autoimmunity and Thyroid Disease Markers.
New
Nazarian et al., Boston, United States. In J Cutan Pathol, Feb 2016
METHODS: Biopsies of chronic urticaria (n=11) and normal skin (n=5) were evaluated with immunostains for CD117, CD3 and dual stains for CD4/T-bet, GATA-3, STAT-3, or BNC-2 (transcription factors specific and mutually exclusive for Th1, Th2, Th17, and Th22 cells, respectively).
Inverse Correlation of Expression of miR-140-5p with Progression of Multiple Sclerosis and Differentiation of Encephalitogenic Th1 cells.
New
Nagarkatti et al., Columbia, United States. In Immunology, Feb 2016
transfection of the synthetic miR-140-5p suppressed activation of Stat1 and the expression of its downstream target, T-bet.
Depletion of CD8+ T Cells Exacerbates CD4+ T Cell-Induced Monocyte-to-Fibroblast Transition in Renal Fibrosis.
New
Du et al., Beijing, China. In J Immunol, Feb 2016
CD4(+) T cells isolated from CD8 KO obstructed kidney expressed more IL-4 and GATA3 and less IFN-γ and T-bet and showed increased monocyte-to-fibroblast transition in vitro compared with those isolated from wild-type obstructed kidney.
T-bet as a key regulator of mucosal immunity.
Review
New
Lord et al., London, United Kingdom. In Immunology, Feb 2016
In addition to regulating other IFNγ producing adaptive immune cells, it is now apparent that T-bet plays a fundamental role in the regulation of innate immune responses across mucosal surfaces.
Age-associated B cells: key mediators of both protective and autoreactive humoral responses.
Review
New
Cancro et al., Philadelphia, United States. In Immunol Rev, Jan 2016
These cells are characterized by a T-BET driven transcriptional program, robust responsiveness to TLR7 and TLR9 ligands, and a propensity for IgG2a/c production.
Enhanced cytotoxic T-cell function and inhibition of tumor progression by Mst1 deficiency.
New
Kinashi et al., Ōsaka, Japan. In Febs Lett, Jan 2016
Mst1(-/-) cytotoxic T cells also exhibited enhanced T-bet expression that was associated with elevated expression levels of IFNγ and granzyme B.
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
New
Impact
Carbone et al., Melbourne, Australia. In Immunity, Jan 2016
We demonstrated that the T-box transcription factors (TFs) Eomes and T-bet combined to control CD8(+)CD103(+) Trm cell formation, such that their coordinate downregulation was crucial for TGF-β cytokine signaling.
Front-Line Memory T Cells Think Outside the T-box… Mostly.
New
Impact
Snyder, Philadelphia, United States. In Immunity, Jan 2016
In this issue of Immunity, Carbone and colleagues show that downregulation of T-box proteins Eomesodermin and T-bet is critical for their differentiation, but residual levels of T-bet are important for long-term Trm survival and function.
Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates.
New
Chang et al., San Diego, United States. In Sci Rep, Dec 2015
Here, we show that deletion of both aPKC isoforms resulted in a deficit in asymmetric divisions, increasing the proportion of daughter cells that inherit high amounts of effector fate-associated molecules, IL-2Rα, T-bet, IFNγR, and interferon regulatory factor 4 (IRF4).
Hobit and human effector T-cell differentiation: The beginning of a long journey.
Review
New
Thiel et al., Berlin, Germany. In Eur J Immunol, Oct 2015
Hobit may initially appear as another "player" in the quest for transcription factors guiding T-cell differentiation; the discoveries of T-bet, Eomes, Blimp-1, and others have significantly contributed to our understanding of how this process is tightly regulated.
Development, Homeostasis, and Heterogeneity of NK Cells and ILC1.
Review
New
Huntington et al., Australia. In Curr Top Microbiol Immunol, Sep 2015
NK cells have previously been viewed to represent a relatively homogeneous group of IFN-γ-producing cells that express the surface markers NK1.1 and natural killer cell p46-related protein (NKp46 or NCR1 encoded by Ncr1) and depend on the transcription factor T-bet for their development.
CD4+CD28- T-cell expansions in ANCA-associated vasculitis and association with arterial stiffness: baseline data from a randomised controlled trial.
New
Impact
Harper et al., Birmingham, United Kingdom. In Lancet, Mar 2015
More CD4+CD28- than CD4+CD28+ T cells expressed T-bet (83·5% [47·5-89·9] vs 12·9 [4·7-22·2], p<0·0001) and secreted IFNγ after stimulation (14·3% [8·4-26·0] vs 0·8 [0·2-1·3], p<0·0001).
Brain-specific transcriptional regulator T-brain-1 controls brain wiring and neuronal activity in autism spectrum disorders.
Review
Hsueh et al., Taipei, Taiwan. In Front Neurosci, 2014
T-brain-1 (TBR1) is a brain-specific T-box transcription factor.
Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα.
Impact
GeneRIF
McHeyzer-Williams et al., Los Angeles, United States. In Nat Immunol, 2012
T-bet is required for the survival and function of memory B cells in vivo.
Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.
GeneRIF
Rocha et al., Paris, France. In Blood, 2012
Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.
The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells.
GeneRIF
Bories et al., Paris, France. In Blood, 2012
A transcriptional enhancer in the T-bet locus has an activity in B cells relying on ETS-binding sites. After IFN-gamma stimulation of Ets-1(-/-) B cells, activated Stat1 no longer binds to the T-bet enhancer or promotes histone modifications at this site.
Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation.
Impact
GeneRIF
Shrikant et al., Buffalo, United States. In Immunity, 2012
inactivation of Foxo1 was essential for instructing T-bet transcription factor-mediated effector differentiation of CD8(+) T cells
Association between gastric cancer and -1993 polymorphism of TBX21 gene.
GeneRIF
Guo et al., Beijing, China. In World J Gastroenterol, 2012
Data suggest that TBX21 -1993 polymorphism might contribute to the risk of gastric cancer, especially to the distant metastasis.
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