Modulation of miR-21 signaling by MPS1 in human glioblastoma.
Bethesda, United States. In Oncotarget, 15 Jun 2015
In this study using reverse phase protein arrays (RPPAs), we assessed MPS1 mediated cell signaling pathways and demonstrated that inhibiting MPS1 could upregulate the expression of the tumor suppressor PDCD4 and MSH2 genes, by down regulating micro RNA-21 (miR-21).
miR-21 in ischemia/reperfusion injury: a double-edged sword?
Shanghai, China. In Physiol Genomics, Dec 2014
Preconditioning-induced upregulation of miR-21 contributes to the protection against subsequent renal I/R injury through the targeting of genes such as the proapoptotic gene programmed cell death 4 and interactions between miR-21 and hypoxia-inducible factor.
The role of microRNA in modulating myocardial ischemia-reperfusion injury.
Galveston, United States. In Physiol Genomics, 2011
By altering the expression of various key elements in cell survival and apoptosis [such as phosphoinositide 3-kinase (PI3K), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), Bcl-2, Mcl-1, heat shock protein (HSP)60, HSP70, HSP20, programmed cell death 4 (Pdcd4), LRRFIP1, Fas ligand (FasL), Sirt-1, etc.], miRNAs alter the response to ischemia-reperfusion injury.
MicroRNA-21 in cardiovascular disease.
Newark, United States. In J Cardiovasc Transl Res, 2010
Programmed cell death 4 (PDCD4), phosphatase and tensin homology deleted from chromosome 10 (PTEN), sprouty1 (SPRY1), and sprouty2 (SPRY2) are the current identified target genes of miR-21 that are involved in miR-21-mediated cardiovascular effects.