MicroRNA-21 Aggravates Cyst Growth in a Model of Polycystic Kidney Disease.
Kansas City, United States. In J Am Soc Nephrol, 17 Jan 2016
RNA sequencing analysis and additional in vivo assays showed that miR-21 inhibits apoptosis of cyst epithelial cells, likely through direct repression of its target gene programmed cell death 4. Thus, miR-21 functions downstream of the cAMP pathway and promotes disease progression in experimental PKD.
The critical roles of miR-21 in anti-cancer effects of curcumin.
Australia. In Ann Transl Med, 31 Dec 2015
Several downstream pathways of miR-21 have been identified including phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), programmed cell death protein 4 (PDCD4) and NF-κB pathways.