GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Programmed cell death 4
T is, PDCD4, programmed cell death 4
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] (from
NCBI)
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Papers on
T is
Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol.
New
Norwich, United Kingdom. In Food Chem, 01 Jul 2013
HTy and HTy-Et also altered the transcription of specific genes involved in apoptosis, as suggested by the up-regulation of BNIP3, BNIP3L, PDCD4 and ATF3 and the activation of caspase-3.
Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells.
New
In J Agric Food Chem, 01 Apr 2013
Gene expression of proteins involved in cell cycle (p21, p53, cyclin B1 and cyclin G2) and programmed cell death (BNIP3, BNIP3L, PDCD4 and ATF3), as well as phase I and phase II detoxifying enzymes CYPA1 and UGT1A10, were evaluated by RT-PCR after 24 h of exposure of Caco-2/TC7 cells to 5, 10 and 50 M of HTy-Ac.
Distinct roles of different fragments of PDCD4 in regulating the metastatic behavior of B16 melanoma cells.
New
Shenyang, China. In Int J Oncol, 27 Mar 2013
In this study, we demonstrated that the levels of the programmed cell death 4 (PDCD4) protein and mRNA were lower in tumor tissues compared with normal tissues.
Overexpression of microRNA-21 regulating PDCD4 during tumorigenesis of liver fluke-associated cholangiocarcinoma contributes to tumor growth and metastasis.
New
Khon Kaen, Thailand. In Tumour Biol, 17 Mar 2013
This study aimed to investigate the role of oncomiR miR-21 and its target, the programmed cell death 4 (PDCD4) in tumor growth and metastasis of the liver fluke Opisthorchis viverrini-associated cholangiocarcinoma (CCA).
miR-21 Promotes Fibrogenic Epithelial-to-Mesenchymal Transition of Epicardial Mesothelial Cells Involving Programmed Cell Death 4 and Sprouty-1.
New
Odense, Denmark. In Plos One, Dec 2012
Several mRNA targets of miR-21 was differentially regulated during fibrogenic EMT of EMCs and miR-21-dependent targeting of Programmed Cell Death 4 (PDCD4) and Sprouty Homolog 1 (SPRY1) significantly contributed to the development of a fibroblastoid phenotype.
Combined MicroRNA In Situ Hybridization and Immunohistochemical Detection of Protein Markers.
New
Hørsholm, Denmark. In Methods Mol Biol, Dec 2012
In this chapter we present a fluorescence-based technology that allows the combination of microRNA in situ hybridization with immunohistochemistry exemplified by the in situ detection of miR-21 and miR-205 in combination with PDCD4 and smooth muscle a-actin.
Differential expression of microRNA expression in tamoxifen-sensitive MCF-7 versus tamoxifen-resistant LY2 human breast cancer cells.
GeneRIF
Louisville, United States. In Cancer Lett, 2012
Data show that 4-OHT reduced PDCD4 mRNA in MCF-7 cells consistent with the increase in miR-21 induced by 4-OHT.
Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers.
GeneRIF
Saga, Japan. In Oncol Rep, 2011
PDCD4 expression was correlated with beta-catenin expression in gastric carcinoma cell lines, but not with E-cadherin, as the binding partner in the cell membrane
MicroRNA-499-5p promotes cellular invasion and tumor metastasis in colorectal cancer by targeting FOXO4 and PDCD4.
GeneRIF
Xi'an, China. In Carcinogenesis, 2011
identified FOXO4 and PDCD4 as direct and functional targets of miR-499-5p
The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death.
GeneRIF
Philadelphia, United States. In Proc Natl Acad Sci U S A, 2011
PDCD4 deficiency in pancreatic beta cells renders them resistant to death, thus preventing type 1 diabetes.
The role of microRNA in modulating myocardial ischemia-reperfusion injury.
Review
Galveston, United States. In Physiol Genomics, 2011
By altering the expression of various key elements in cell survival and apoptosis [such as phosphoinositide 3-kinase (PI3K), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), Bcl-2, Mcl-1, heat shock protein (HSP)60, HSP70, HSP20, programmed cell death 4 (Pdcd4), LRRFIP1, Fas ligand (FasL), Sirt-1, etc.], miRNAs alter the response to ischemia-reperfusion injury.
[The expression of PD4 and its significance in human laryngeal carcinoma].
GeneRIF
Beijing, China. In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2011
PD4 expression was elevated in laryngeal carcinoma, and might be closely related to mycoplasma infection.
Resistance may not be futile: microRNA biomarkers for chemoresistance and potential therapeutics.
Review
Phoenix, United States. In Mol Cancer Ther, 2010
microRNAs have recently been identified as playing a role in the regulation of key genes implicated as cancer therapeutic targets or in mechanisms of chemoresistance including EGFR, MDR1, PTEN, Bak1, and PDCD4 among others.
MicroRNA-21 in cardiovascular disease.
Review
Newark, United States. In J Cardiovasc Transl Res, 2010
Programmed cell death 4 (PDCD4), phosphatase and tensin homology deleted from chromosome 10 (PTEN), sprouty1 (SPRY1), and sprouty2 (SPRY2) are the current identified target genes of miR-21 that are involved in miR-21-mediated cardiovascular effects.
Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21.
Impact
GeneRIF
Dublin, Ireland. In Nat Immunol, 2010
miR-21 regulates PDCD4 expression after LPS stimulation.
A network model of a cooperative genetic landscape in brain tumors.
Impact
Chicago, United States. In Jama, 2009
A multigene risk scoring model based on 7 landscape genes (POLD2, CYCS, MYC, AKR1C3, YME1L1, ANXA7, and PDCD4) is associated with the duration of overall survival in 189 glioblastoma samples from TCGA (global log-rank P = .02
The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation.
Review
Marburg an der Lahn, Germany. In Biol Cell, 2009
Pdcd4 (programmed cell death 4) has been known as a tumour suppressor gene and potential target for anticancer therapies for several years.
SMAD proteins control DROSHA-mediated microRNA maturation.
Impact
Boston, United States. In Nature, 2008
miR-21 downregulates PDCD4 (programmed cell death 4), which in turn acts as a negative regulator of smooth muscle contractile genes.
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Impact
GeneRIF
New York City, United States. In Science, 2006
in response to mitogens, PDCD4 was rapidly phosphorylated by protein kinase S6K1 & then degraded by ubiquitin ligase SCF(betaTRCP); it is proposed that regulated degradation of PDCD4 in response to mitogens allows efficient protein synthesis & cell growth
Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells.
Review
GeneRIF
Marburg an der Lahn, Germany. In Ann N Y Acad Sci, 2004
overexpression of PDCD4 in carcinoid cells results in inhibition of cell proliferation.
