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Programmed cell death 4

T is, PDCD4, programmed cell death 4
This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: miR, V1a, PTEN, CAN, HAD
Papers on T is
miR-183 regulates biological behavior in papillary thyroid carcinoma by targeting the programmed cell death 4.
Fang et al., Shanghai, China. In Oncol Rep, 31 Jul 2015
The aim of the present study was to examine the expression levels of miR-183 in PTC and investigate whether its potential roles involved targeting the programmed cell death 4 (PDCD4).
Insights into possible cell-death markers in the diatom Skeletonema marinoi in response to senescence and silica starvation.
Romano et al., Napoli, Italy. In Mar Genomics, 25 Jul 2015
Here we investigate the gene expression of different target genes related to cell death, namely programmed cell death 4 (PDCD4), tumor susceptibility gene 101 (TSG101), developmental and cell death (DCD) domain, death specific protein (DSP) and metacaspase (MC), using RT-qPCR in the cosmopolitan coastal centric diatom species Skeletonema marinoi, which contributes significantly to phytoplankton blooms in temperate waters.
Effect of Combined Treatment with Ursolic Acid and Resveratrol on Skin Tumor Promotion by 12-O-tetradecanoylphorbol-13-acetate.
DiGiovanni et al., Austin, United States. In Cancer Prev Res (phila), 22 Jul 2015
The combination of UA + Res inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-κB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors such as p21 and PDCD4 to a greater extent compared to the groups treated with the individual compounds.
Ultrasound-targeted microbubble destruction mediated microRNA-21 transfection regulated PDCD4/NF-κB/TNF-α pathway to prevent coronary microembolization-induced cardiac dysfunction.
Wen et al., Nanning, China. In Gene Ther, 16 Jul 2015
microRNA-21 protects myocardium mainly via regulation of its target gene programmed cell death 4 (PDCD4).
Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survival.
Ruppert et al., Morgantown, United States. In Oncogenesis, Dec 2014
Using a combinatorial approach that included in silico as well as loss- and gain-of-function in vitro assays, we identified miR-206-mediated repression of the pro-apoptotic molecules programmed cell death 4 (PDCD4) and connexin 43 (CX43/GJA1).
MiR-21: an environmental driver of malignant melanoma?
Melnik, Osnabrück, Germany. In J Transl Med, Dec 2014
MiR-21 is an oncomiR that affects critical target genes of malignant melanoma, resulting in sustained proliferation (PTEN, PI3K, Sprouty, PDCD4, FOXO1, TIPE2, p53, cyclin D1), evasion from apoptosis (FOXO1, FBXO11, APAF1, TIMP3, TIPE2), genetic instability (MSH2, FBXO11, hTERT), increased oxidative stress (FOXO1), angiogenesis (PTEN, HIF1α, TIMP3), invasion and metastasis (APAF1, PTEN, PDCD4, TIMP3).
miR-21 in ischemia/reperfusion injury: a double-edged sword?
Ding et al., Shanghai, China. In Physiol Genomics, Dec 2014
Preconditioning-induced upregulation of miR-21 contributes to the protection against subsequent renal I/R injury through the targeting of genes such as the proapoptotic gene programmed cell death 4 and interactions between miR-21 and hypoxia-inducible factor.
The role of microRNAs in the control and mechanism of action of IL-10.
O'Neill et al., Dublin, Ireland. In Curr Top Microbiol Immunol, 2013
Another miRNA, miR-21, has been shown to indirectly regulate IL-10 via downregulation of the IL-10 inhibitor PDCD4.
Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc.
Yang et al., Lexington, United States. In Biochim Biophys Acta, 2012
Pdcd4 knockdown up-regulates MAP kinase kinase kinase kinase 1 (MAP4K1) expression and increases phosphorylation of c-Jun.
Role of microRNA-21 and programmed cell death 4 in the pathogenesis of human uterine leiomyomas.
Christenson et al., Kansas City, United States. In Fertil Steril, 2012
Elevated leiomyoma miR-21 levels are predicted to decrease PDCD-4 levels, thus leiomyomas differ from other tumors where loss of PDCD-4 is associated with tumor progression.
Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses.
Platanias et al., Chicago, United States. In Mol Cell Biol, 2012
IFN-dependent phosphorylation of PDCD4 results in downregulation of PDCD4 protein levels as the phosphorylated form of PDCD4 interacts with the ubiquitin ligase beta-TRCP (beta-transducin repeat-containing protein) and undergoes degradation.
PTEN and PDCD4 are bona fide targets of microRNA-21 in human cholangiocarcinoma.
Chen et al., Beijing, China. In Chin Med Sci J, 2012
microRNA-21 expression is up-regulated in human cholangiocarcinoma and PTEN, PDCD4 are direct effectors of microRNA-21.
Protein kinase GSK3β regulates tumor suppressor Pdcd4 expression in lung cancer cells.
Korobko et al., Moscow, Russia. In Dokl Biochem Biophys, 2012
role of GSK3beta in Pdcd4 expression lung cancer cells
The role of microRNA in modulating myocardial ischemia-reperfusion injury.
Birnbaum et al., Galveston, United States. In Physiol Genomics, 2011
By altering the expression of various key elements in cell survival and apoptosis [such as phosphoinositide 3-kinase (PI3K), phosphatase and tensin homolog deleted on chromosome 10 (PTEN), Bcl-2, Mcl-1, heat shock protein (HSP)60, HSP70, HSP20, programmed cell death 4 (Pdcd4), LRRFIP1, Fas ligand (FasL), Sirt-1, etc.], miRNAs alter the response to ischemia-reperfusion injury.
Resistance may not be futile: microRNA biomarkers for chemoresistance and potential therapeutics.
Weiss et al., Phoenix, United States. In Mol Cancer Ther, 2010
microRNAs have recently been identified as playing a role in the regulation of key genes implicated as cancer therapeutic targets or in mechanisms of chemoresistance including EGFR, MDR1, PTEN, Bak1, and PDCD4 among others.
MicroRNA-21 in cardiovascular disease.
Zhang et al., Newark, United States. In J Cardiovasc Transl Res, 2010
Programmed cell death 4 (PDCD4), phosphatase and tensin homology deleted from chromosome 10 (PTEN), sprouty1 (SPRY1), and sprouty2 (SPRY2) are the current identified target genes of miR-21 that are involved in miR-21-mediated cardiovascular effects.
Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21.
O'Neill et al., Dublin, Ireland. In Nat Immunol, 2010
miR-21 regulates PDCD4 expression after LPS stimulation.
A network model of a cooperative genetic landscape in brain tumors.
Sikic et al., Chicago, United States. In Jama, 2009
A multigene risk scoring model based on 7 landscape genes (POLD2, CYCS, MYC, AKR1C3, YME1L1, ANXA7, and PDCD4) is associated with the duration of overall survival in 189 glioblastoma samples from TCGA (global log-rank P = .02
SMAD proteins control DROSHA-mediated microRNA maturation.
Hata et al., Boston, United States. In Nature, 2008
miR-21 downregulates PDCD4 (programmed cell death 4), which in turn acts as a negative regulator of smooth muscle contractile genes.
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.
Pagano et al., New York City, United States. In Science, 2006
in response to mitogens, PDCD4 was rapidly phosphorylated by protein kinase S6K1 & then degraded by ubiquitin ligase SCF(betaTRCP); it is proposed that regulated degradation of PDCD4 in response to mitogens allows efficient protein synthesis & cell growth
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