gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Synovial sarcoma translocation, chromosome 18

SYT-SSX, SYT, Synaptotagmin I, SYT-SSX1, SYT-SSX2
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010] (from NCBI)
Top mentioned proteins: SSX2, POLYMERASE, CAN, HAD, C2A
Papers using SYT-SSX antibodies
Magnocellular pathway impairment in schizophrenia: evidence from functional magnetic resonance imaging
Fox Michael A., In PLoS ONE, 2007
... First, the cDNAs encoding Syt I were subcloned into the pCMV-IRES2EGFP (Clontech #6029-1) ...
Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons
Chapman Edwin R. et al., In The Journal of Cell Biology, 2003
... The following antibodies were purchased from the indicated companies: mouse monoclonal anti–Syt II (BD Biosciences), mouse monoclonal anti–SNAP-25-C (Research ...
Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I
Söllner Thomas H. et al., In The Journal of Cell Biology, 1998
... The anti–synaptotagmin I monoclonal antibody CI.41.1 was from Synaptic Systems.
Papers on SYT-SSX
Novel BCOR-MAML3 and ZC3H7B-BCOR Gene Fusions in Undifferentiated Small Blue Round Cell Sarcomas.
Antonescu et al., Birmingham, United Kingdom. In Am J Surg Pathol, Feb 2016
We then screened a total of 75 SBRCTs lacking EWSR1, FUS, SYT, CIC, and BCOR-CCNB3 abnormalities for BCOR break-apart probes by fluorescence in situ hybridization to detect potential recurrent BCOR gene rearrangements outside the typical X-chromosomal inversion.
[Synovial sarcoma in children and adolescents].
Corradini et al., Nancy, France. In Bull Cancer, Feb 2016
translocation resulting in two chimeric fusion genes SYT-SSX1 and SYT-SSX2, confirming histological diagnosis.
Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis.
Zhou et al., Beijing, China. In Embo Rep, Jan 2016
Here, we show that synaptotagmin-11 (Syt11), a non-Ca(2+)-binding Syt implicated in schizophrenia and Parkinson's disease, inhibits clathrin-mediated endocytosis (CME) and bulk endocytosis in dorsal root ganglion neurons.
Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis.
Jaiswal et al., Washington, D.C., United States. In Cell Death Differ, Nov 2015
In most cells, lysosomes express the synaptotagmin (Syt) isoform Syt VII; however, this isoform is not present on astrocyte lysosomes and exogenous expression of Syt VII on lysosome inhibits their exocytosis.
Calcium signaling in membrane repair.
Xu et al., Ann Arbor, United States. In Semin Cell Dev Biol, Sep 2015
Multiple calcium sensors, including synaptotagmin (Syt) VII, dysferlin, and apoptosis-linked gene-2 (ALG-2), are involved in PM resealing, suggesting that Ca(2+) may regulate multiple steps of the repair process.
[About a rare tumor of the kidney: Malignant mixed epithelial and stromal tumor].
Kchir et al., Tunisia. In Prog Urol, May 2015
Analysis by reverse transcriptase polymerase chain reaction (RT-PCR) failed to identify the SYT-SSX1 or SYT-SSX2 fusion transcripts characteristic of synovial sarcoma.
Depression-like Behavior Induced by Nesfatin-1 in Rats: Involvement of Increased Immune Activation and Imbalance of Synaptic Vesicle Proteins.
Chen et al., China. In Front Neurosci, 2014
The plasma concentrations of nesfatin-1, interleukin 6 (IL-6), and C-reactive protein (CRP); and the hypothalamic expression levels of nesfatin-1, synapsin I, and synaptotagmin I mRNA were evaluated in nesfatin-1 chronically treated rats.
Exocytosis and synaptic vesicle function.
Shin, Galveston, United States. In Compr Physiol, 2014
Synaptotagmin 1 (Syt1), the most studied major isoform among 16 Syt isoforms, mediates Ca(2+)-triggered synaptic vesicle exocytosis by interacting with the target membranes and SNARE/complexin complex.
Malignant mixed epithelial and stromal tumor of the kidney: the second male case and review of literature.
Xiang et al., Hangzhou, China. In Int J Clin Exp Pathol, 2013
Analysis by reverse transcriptase polymerase chain reaction (RT-PCR) failed to identify the SYT-SSX1 or SYT-SSX2 fusion transcripts characteristic of synovial sarcoma.
A patient with primary pericardial synovial sarcoma who presented with cardiac tamponade: a case report and review of the literature.
Ishizaka et al., Ōsaka, Japan. In Intern Med, 2013
A histological analysis showed CD99 positivity and SYT gene rearrangement, leading to a diagnosis of synovial sarcoma arising from the left lateral pericardial surface.
Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release.
Söllner et al., Heidelberg, Germany. In Embo J, 2012
Together with synaptotagmin 1, complexin synchronizes and stimulates rapid fusion of accumulated docked vesicles in response to physiological Ca(2+) concentrations.
Molecular level interaction of inositol hexaphosphate with the C2B domain of human synaptotagmin I.
Yu et al., Taiwan. In Biochemistry, 2012
The calcium binding site to the C2A domain of SYT1 has been identified; this SYT1 domain activates exocytosis of secretory vesicles during neurotransmitter release.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Human APP gene expression in nerve cells of Drosophila melanogaster causes alteration of synaptoptagmin 1 mRNA level.
Schwarzman et al., Saint Petersburg, Russia. In Dokl Biochem Biophys, 2012
effect of APP gene on synaptotagmin 1 mRNA level
SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes.
Logie et al., Nijmegen, Netherlands. In Plos One, 2011
SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes
Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.
Chapman et al., Madison, United States. In Cell, 2011
Though the Ca(2+) sensor for rapid exocytosis, synaptotagmin I, has been studied in depth, the sensor for asynchronous release remains unknown.
Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair.
Remold et al., Boston, United States. In Nat Immunol, 2009
Plasma membrane repair depended on prostaglandin E(2) (PGE(2)), which regulates synaptotagmin 7 (Syt-7), the calcium sensor involved in the lysosome-mediated repair mechanism.
How does synaptotagmin trigger neurotransmitter release?
Chapman, Madison, United States. In Annu Rev Biochem, 2007
Here, we summarize findings obtained from genetically modified neurons and neuroendocrine cells, as well as from reconstituted systems, which are beginning to reveal the molecular mechanism by which Ca(2+)-acting on the synaptic vesicle (SV) protein synaptotagmin I (syt)-triggers rapid exocytosis.
Modeling synovial sarcoma: timing is everything.
Meltzer et al., Bethesda, United States. In Cancer Cell, 2007
They show that expression of the SYT-SSX2 fusion gene yields a highly penetrant and representative model of human synovial sarcoma, but only if expression occurs in a particular biologic context.
A conditional mouse model of synovial sarcoma: insights into a myogenic origin.
Capecchi et al., Salt Lake City, United States. In Cancer Cell, 2007
Synovial sarcoma is an aggressive soft-tissue malignancy marked by a unique t(X;18) translocation leading to expression of a chimeric SYT-SSX fusion protein.
share on facebooktweetadd +1mail to friends