Calcium signaling in membrane repair.
Ann Arbor, United States. In Semin Cell Dev Biol, Sep 2015
Multiple calcium sensors, including synaptotagmin (Syt) VII, dysferlin, and apoptosis-linked gene-2 (ALG-2), are involved in PM resealing, suggesting that Ca(2+) may regulate multiple steps of the repair process.
Exocytosis and synaptic vesicle function.
Galveston, United States. In Compr Physiol, 2014
Synaptotagmin 1 (Syt1), the most studied major isoform among 16 Syt isoforms, mediates Ca(2+)-triggered synaptic vesicle exocytosis by interacting with the target membranes and SNARE/complexin complex.
How does synaptotagmin trigger neurotransmitter release?
Madison, United States. In Annu Rev Biochem, 2007
Here, we summarize findings obtained from genetically modified neurons and neuroendocrine cells, as well as from reconstituted systems, which are beginning to reveal the molecular mechanism by which Ca(2+)-acting on the synaptic vesicle (SV) protein synaptotagmin I (syt)-triggers rapid exocytosis.
Modeling synovial sarcoma: timing is everything.
Bethesda, United States. In Cancer Cell, 2007
They show that expression of the SYT-SSX2 fusion gene yields a highly penetrant and representative model of human synovial sarcoma, but only if expression occurs in a particular biologic context.