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Syntaxin 3

syntaxin 3, syntaxin 3A
The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: SNAP-23, ACID, CAN, VAMP2, SNAP-25
Papers on syntaxin 3
The localisation of the apical Par/Cdc42 polarity module is specifically affected in microvillus inclusion disease.
Ruemmele et al., Rennes, France. In Biol Cell, Jan 2016
It is caused by mutations in MYO5B or syntaxin 3 (STX3) affecting apical membrane trafficking.
The zebrafish pinball wizard gene encodes WRB, a tail-anchored-protein receptor essential for inner-ear hair cells and retinal photoreceptors.
Corey et al., Boston, United States. In J Physiol, Dec 2015
The expression of synaptobrevin and syntaxin 3, TA proteins essential for vesicle fusion, was reduced in the synaptic layers of mutant retina, consistent with a role for the pwi/WRB protein in TA-protein processing.
Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin.
Bröer et al., Canberra, Australia. In J Biol Chem, Nov 2015
Syntaxin 1A and syntaxin 3 inhibit the membrane expression of B(0)AT1 by competing with collectrin for access.
Autosomal recessive congenital cataract, intellectual disability phenotype linked to STX3 in a consanguineous Tunisian family.
Chaabouni et al., Tunisia. In Clin Genet, Sep 2015
We identified a new specific lens gene named syntaxin 3 linked to the studied phenotype.
Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes.
Goldenring et al., Nashville, United States. In J Cell Sci, May 2015
Rab11a deficiency in enterocytes altered the apical localization of syntaxin 3.
An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells.
Bréchard et al., Luxembourg, Luxembourg. In J Leukoc Biol, Mar 2015
Secondly, after screening of SNARE genes by microarray experiments, we selected STX3 for further functional studies.
Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4: a potential correlation with autocrine signaling.
Baron et al., Groningen, Netherlands. In Mol Cell Biol, Feb 2015
Thus, downregulation and overexpression of syntaxin 4 but not syntaxin 3 in oligodendrocyte progenitor cells but not immature oligodendrocytes impeded MBP mRNA transcription, thereby preventing MBP protein synthesis.
The major myelin-resident protein PLP is transported to myelin membranes via a transcytotic mechanism: involvement of sulfatide.
Hoekstra et al., Groningen, Netherlands. In Mol Cell Biol, 2015
Upon biosynthesis, PLP traffics to myelin membranes via syntaxin 3-mediated docking at the apical-surface-like cell body plasma membrane, which is followed by subsequent internalization and transport to the basolateral-surface-like myelin sheet.
Mechanisms of Intestinal Serotonin Transporter (SERT) Upregulation by TGF-β1 Induced Non-Smad Pathways.
Gill et al., Chicago, United States. In Plos One, 2014
TGF-β1 increased the association of SERT with the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) syntaxin 3 (STX3) and promoted exocytosis of SERT.
A role for syntaxin 3 in the secretion of IL-6 from dendritic cells following activation of toll-like receptors.
Loscher et al., Dublin, Ireland. In Front Immunol, 2013
Of interest, STX3 mRNA was up-regulated in response to TLR4 and TLR7 activation but not TLR2 activation.
Syntaxins 3 and 4 mediate vesicular trafficking of α5β1 and α3β1 integrins and cancer cell migration.
Hu et al., Louisville, United States. In Int J Oncol, 2011
siRNA knockdown (KD) of syntaxins 3 and 4 in HeLa cells reduced cell surface expression of alpha5beta1 and alpha3beta1 integrins
SNAP-23 and syntaxin-3 are required for chemokine release by mature human mast cells.
Lorentz et al., Stuttgart, Germany. In Mol Immunol, 2011
STX-3 and SNAP-23 are crucial for the release of all chemokines in mature human mast cells
A role for the SNARE protein syntaxin 3 in human cytomegalovirus morphogenesis.
Fraile-Ramos et al., Madrid, Spain. In Cell Microbiol, 2011
These results demonstrate a function for STX3 in human cytomegalovirus morphogenesis, and unravel a new role for this SNARE protein in late endosomes/lysosomes compartments.
Syntaxin 3 is necessary for cAMP- and cGMP-regulated exocytosis of CFTR: implications for enterotoxigenic diarrhea.
Ameen et al., Pittsburgh, United States. In Am J Physiol Cell Physiol, 2010
syntaxin 3 interacts with CFTR in vivo.
Munc18b regulates core SNARE complex assembly and constitutive exocytosis by interacting with the N-peptide and the closed-conformation C-terminus of syntaxin 3.
Fussenegger et al., Basel, Switzerland. In Biochem J, 2010
Munc18b is functionally coupled to the assembly of exocytic SNARE complexes and increases exocytosis by interacting with the N-peptide and closed-conformation C-terminus of Stx3, thereby neutralizing the secretion-inhibitory effect of this SNARE.
SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods.
Sung et al., New York City, United States. In Cell, 2007
This membrane coupling is regulated by the FYVE domain-containing protein, SARA, through its direct interaction with PI3P, rhodopsin, and SNARE protein syntaxin 3. Our model, in contrast to the previously proposed evagination model, suggests that the vesicular delivery of rhodopsin in the OS concentrates rhodopsin into discs, and this process directly participates in disc biogenesis.
Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3.
Davletov et al., Cambridge, United Kingdom. In Nature, 2006
Here we show that syntaxin 3 (STX3), a plasma membrane protein, has an important role in the growth of neurites, and also serves as a direct target for omega-6 arachidonic acid.
Interaction of syntaxins with epithelial ion channels.
Warnock et al., Birmingham, United States. In Curr Opin Nephrol Hypertens, 2000
This review examines recent studies of the cystic fibrosis transmembrane conductance regulator and the epithelial sodium channel which define distinct roles of syntaxin 1A and syntaxin 3 in the regulation of surface expression as well as intrinsic properties of these epithelial ion transporters.
Membrane traffic in polarized epithelial cells.
Altschuler et al., San Francisco, United States. In Curr Opin Cell Biol, 2000
Recent results have shown that targeting to the basolateral surface utilizes the exocyst, whereas traffic to the apical surface uses syntaxin 3. Endocytosis at the apical surface is regulated by ARF6.
Vesicular transport and kidney development.
Olkkonen et al., Helsinki, Finland. In Int J Dev Biol, 1998
We summarize here data on the presence and the functional role of vesicle transport proteins in the kidney, and describe work addressing the developmentally regulated expression and localization of three molecules suggested to be involved in polarized trafficking in kidney epithelia, Rab17, syntaxin 3, and Munc-18-2.
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