SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods.
New York City, United States. In Cell, 2007
This membrane coupling is regulated by the FYVE domain-containing protein, SARA, through its direct interaction with PI3P, rhodopsin, and SNARE protein syntaxin 3. Our model, in contrast to the previously proposed evagination model, suggests that the vesicular delivery of rhodopsin in the OS concentrates rhodopsin into discs, and this process directly participates in disc biogenesis.
Interaction of syntaxins with epithelial ion channels.
Birmingham, United States. In Curr Opin Nephrol Hypertens, 2000
This review examines recent studies of the cystic fibrosis transmembrane conductance regulator and the epithelial sodium channel which define distinct roles of syntaxin 1A and syntaxin 3 in the regulation of surface expression as well as intrinsic properties of these epithelial ion transporters.
Membrane traffic in polarized epithelial cells.
San Francisco, United States. In Curr Opin Cell Biol, 2000
Recent results have shown that targeting to the basolateral surface utilizes the exocyst, whereas traffic to the apical surface uses syntaxin 3. Endocytosis at the apical surface is regulated by ARF6.
Vesicular transport and kidney development.
Helsinki, Finland. In Int J Dev Biol, 1998
We summarize here data on the presence and the functional role of vesicle transport proteins in the kidney, and describe work addressing the developmentally regulated expression and localization of three molecules suggested to be involved in polarized trafficking in kidney epithelia, Rab17, syntaxin 3, and Munc-18-2.