Altered α-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains.
Copenhagen, Denmark. In J Neurochem, Jan 2016
Previously, it has been shown that α-synuclein, parkin, and synphilin-1 display disease-specific transcription patterns in frontal cortex in PD, dementia with Lewy bodies, and MSA, and thus may mediate the development of α-synucleinopathies.
Splicing variants of porcine synphilin-1.
Århus, Denmark. In Meta Gene, Sep 2015
The presented work reports the molecular cloning and characterization of the porcine (Sus scrofa) synphilin-1 cDNA (SNCAIP) and three splice variants hereof.
Expression of Neuronal and Signaling Proteins in Penumbra around a Photothrombotic Infarction Core in Rat Cerebral Cortex.
Rostov-na-Donu, Russia. In Biochemistry (mosc), Jun 2015
The observed upregulation of penumbra proteins involved in maintaining neurite integrity and guidance (NAV3, MAP1, CRMP2, PMP22); intercellular interactions (N-cadherin); synaptic transmission (glutamate decarboxylase, tryptophan hydroxylase, Munc-18-1, Munc-18-3, and synphilin-1); mitochondria quality control and mitophagy (PINK1 and Parkin); ubiquitin-mediated proteolysis and tissue clearance (UCHL1, PINK1, Parkin, synphilin-1); and signaling proteins (PKBα and ERK5) could be associated with tissue recovery.