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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Synaptogyrin 1

SYNGR1, synaptogyrin 1
This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, OUT, HAD, BRG1, FLI-1
Papers on SYNGR1
Dengue NS3, an RNAi suppressor, modulates the human miRNA pathways through its interacting partner.
Bhatnagar et al., New Delhi, India. In Biochem J, Nov 2015
Further studies on the miRNA-mRNA relationship along with mRNA profiling of samples overexpressing dvNS3 revealed up-regulation of TAZ (tafazzin) and SYNGR1 (synaptogyrin 1), known dengue viral host factors (DVHFs).
Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases.
Wallace et al., Cambridge, United Kingdom. In Hum Mol Genet, Jul 2015
Previously published candidate causal genes were over-represented amongst genes exhibiting colocalisation (odds ratio > 1.5), and we identified evidence for colocalisation (posterior odds > 5) between cis eQTLs in at least one cell type and at least one disease for six genes: ADAM15, RGS1, CARD9, LTBR, CTSH and SYNGR1.
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
Bae et al., Cambridge, United States. In Ann Rheum Dis, Mar 2015
RESULTS: We identified eight new rheumatoid arthritis susceptibility loci (TNFSF4, LBH, EOMES, ETS1-FLI1, COG6, RAD51B, UBASH3A and SYNGR1) that passed a genome-wide significance threshold (p<5×10(-8)), with evidence for three independent risk alleles at 1q25/TNFSF4.
Prediction of recurrence in low and intermediate risk non-muscle invasive bladder cancer by real-time quantitative PCR analysis: cDNA microarray results.
Babjuk et al., Praha, Czech Republic. In Neoplasma, 2012
The significant expression was observed in the group of patients without recurrence by 30 genes of which the highest differences were detected by ANXA1, ARHGEF4, FLJ32252, GNE, NINJ1, PRICKLE1, PSAT1, RNASE1, SPTAN1, SYNGR1, TNFSF15, TSPAN1, and WDR34.
Optimisation of over-expression in E. coli and biophysical characterisation of human membrane protein synaptogyrin 1.
Nordlund et al., Stockholm, Sweden. In Plos One, 2011
SYNGR1 was soluble and stable in a variety of mild detergents and multiple biophysical methods confirmed the folded state of the protein.
Association study and mutational screening of SYNGR1 as a candidate susceptibility gene for schizophrenia.
Barlati et al., Brescia, Italy. In Psychiatr Genet, 2009
The results of association study support a contribution of SYNGR1 to schizophrenia susceptibility.
No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population.
Li et al., Shanghai, China. In Psychiatry Res, 2009
A case-control study with synaptogyrin 1 was conducted in 506 bipolar disorder patients and 507 healthy individuals from the Han Chinese population. No association was found in this study.
Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia.
Chen et al., Taiwan. In J Psychiatr Res, 2007
These mutations were not found in 507 control subjects, suggesting further functional assays are warranted to verify their relevance to the pathogenesis of schizophrenia.
Molecular genetics of bipolar disorder and depression.
Kato, Wako, Japan. In Psychiatry Clin Neurosci, 2007
Several candidate genes for schizophrenia may also be associated with bipolar disorder: G72, DISC1, NRG1, RGS4, NCAM1, DAO, GRM3, GRM4, GRIN2B, MLC1, SYNGR1, and SLC12A6.
SYNGR1 is associated with schizophrenia and bipolar disorder in southern India.
Brahmachari et al., Delhi, India. In J Hum Genet, 2004
Our results support SYNGR1 as a probable susceptibility gene for schizophrenia and bipolar disorder.
Characterization of synaptogyrin 3 as a new synaptic vesicle protein.
Janz et al., Houston, United States. In J Comp Neurol, 2004
Synaptogyrin 1 is a synaptic vesicle protein; cellugyrin, by contrast, is absent from synaptic vesicles.
A nonsense mutation in the synaptogyrin 1 gene in a family with schizophrenia.
Brahmachari et al., Delhi, India. In Biol Psychiatry, 2004
This research found a novel nonsense mutation (Trp27Ter) in exon 2 of the SYNGR1 gene in a family multiply affected with schizophrenia. And expressed in the brain.
Tetraspan vesicle membrane proteins: synthesis, subcellular localization, and functional properties.
Leube et al., Mainz, Germany. In Int Rev Cytol, 2001
In mammals synaptophysin, synaptoporin, pantophysin, and mitsugumin29 constitute the physins, synaptogyrin 1-4 the gyrins, and SCAMP1-5 the SCAMPs.
Characterization of the human synaptogyrin gene family.
Dumanski et al., Stockholm, Sweden. In Hum Genet, 1998
Using an expressed sequence tag-based approach we characterized human (SYNGR1) and mouse (Syngr1) orthologs of the previously cloned rat synaptogyrin gene (RATSYNGR1).
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