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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Syndecan 1

syndecan-1, CD138, syndecan-2
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, CD20, CD38, CD45
Papers using syndecan-1 antibodies
Vigorous Premalignancy-specific Effector T Cell Response in the Bone Marrow of Patients with Monoclonal Gammopathy
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Geller Matthew D. et al., In The Journal of Experimental Medicine, 2001
... BM mononuclear cells were separated into tumor/preneoplastic (CD138 positive) and nontumor (CD138 negative) fractions using CD138 magnetic beads using the manufacturer's protocol (Miltenyi Biotec) ( ...
BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells
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Noelle Randolph J. et al., In The Journal of Experimental Medicine, 2001
... anti–mouse CD138 (Syndecan-1, clone 281-2; BD Biosciences).
The syndecans, tuners of transmembrane signaling
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Taylor Amanda L. et al., In The Journal of Cell Biology, 1998
... terminus of mouse syndecan-1 was obtained from Santa Cruz Biotechnology, Inc ...
Silencing of B Cell Receptor Signals in Human Naive B Cells
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Müschen Markus et al., In The Journal of Experimental Medicine, 1996
... cells were depleted using an anti-CD20 IgG1 antibody (BD Biosciences) together with anti-IgG1 beads and anti-CD138 beads (Miltenyi Biotec), respectively ( ...
Regulation of anti-HIV-1 activity of RANTES by heparan sulfate proteoglycans
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Uhlin-Hansen Lars et al., In Glycoconjugate Journal, 1996
... FITC-, PE- and PerCP-conjugated anti- CD45, -3, - 4, -8, -19, -56 and anti-CD138 (syndecan-1) antibodies were obtained from Becton Dickinson (San Jose, CA, USA) ...
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Papers on syndecan-1
Proteoglycans in liver cancer.
Review
New
Kovalszky et al., Budapest, Hungary. In World J Gastroenterol, Feb 2016
This article details and discusses the roles of syndecan-1, glypicans, agrin, perlecan, collagen XVIII/endostatin, endocan, serglycin, decorin, biglycan, asporin, fibromodulin, lumican, and versican in liver function.
The atypical IκB protein IκBNS is important for Toll-like receptor-induced IL-10 production in B cells.
New
Touma et al., Niigata, Japan. In Immunology, Feb 2016
In addition, IκBNS -deficient B cells showed reduced expression of Prdm1 and Irf4 and failed to generate IL-10(+) CD138(+) plasmablasts.
Distinctions among Circulating Antibody-Secreting Cell Populations, Including B-1 Cells, in Human Adult Peripheral Blood.
New
Rothstein et al., Havana, Cuba. In J Immunol, Feb 2016
However, cytokine treatment of 20(+)38(hi) B cells induces loss of CD20 and acquisition of CD138, suggesting that 20(+)38(hi) B cells are precursors to PBs or pre-PBs.
Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects.
New
Carlsten et al., Vancouver, Canada. In Part Fibre Toxicol, Dec 2015
Biopsies sections were immunostained for tryptase, eosinophil cationic protein (ECP), neutrophil elastase (NE), CD138, CD4 and interleukin (IL)-4.
Emerging Liver-Kidney Interactions in Nonalcoholic Fatty Liver Disease.
Review
New
Gambino et al., Torino, Italy. In Trends Mol Med, Oct 2015
NAFLD affects renal injury through lipoprotein dysmetabolism and altered secretion of the hepatokines fibroblast growth factor-21, fetuin-A, insulin-like growth factor-1, and syndecan-1.
Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group.
New
Impact
Moreau et al., Torino, Italy. In J Clin Oncol, Oct 2015
We combined the International Staging System (ISS) with chromosomal abnormalities (CA) detected by interphase fluorescent in situ hybridization after CD138 plasma cell purification and serum lactate dehydrogenase (LDH) to evaluate their prognostic value in newly diagnosed MM (NDMM).
Monoclonal antibodies in myeloma.
Review
New
Plesner et al., Gießen, Germany. In Clin Adv Hematol Oncol, Sep 2015
Our review focuses on a small number of promising mAbs directed against molecules on the surface of myeloma cells, including CS1 (elotuzumab), CD38 (daratumumab, SAR650984, MOR03087), CD56 (lorvotuzumab mertansine), and CD138/syndecan-1 (BT062/indatuximab ravtansine).
Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow.
New
Impact
Lee et al., Atlanta, United States. In Immunity, Aug 2015
Here we used CD19, CD38, and CD138 to identify four PC subsets in human bone marrow (BM).
Therapeutic Efficacy of Alpha-RIT Using a (213)Bi-Anti-hCD138 Antibody in a Mouse Model of Ovarian Peritoneal Carcinomatosis.
Chérel et al., Nantes, France. In Front Med (lausanne), 2014
This study aims to first develop alpha-RIT using an anti-CD138 mAb radiolabeled with an alpha-emitter, bismuth-213 ((213)Bi-B-B4) and HIPEC in a nude mouse model and second to compare and combine these techniques.
Prognostic and clinical significance of syndecan-1 in colorectal cancer: a meta-analysis.
Review
Chen et al., Nanning, China. In Bmc Gastroenterol, 2014
BACKGROUND: Syndecan-1 plays a vital role in the suppression, transformation, and migration of several cancer types, including colorectal cancer (CRC).
Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication.
Review
Dobra et al., Stockholm, Sweden. In Dis Markers, 2014
Syndecan-1, a cell surface heparan sulfate proteoglycan, is critically involved in the differentiation and prognosis of various tumors.
Cytogenetic Study and Analysis of Protein Expression in Plasma Cell Myeloma with t(11;14)(q13;q32): Absence of BCL6 and SOX11, and Infrequent Expression of CD20 and PAX5.
Miura et al., In J Clin Exp Hematop, 2014
The expression of CD19, CD56, and CD138 was detected in one (0.7%), nine (60%), and 13 patients (87%), respectively.
Best treatment strategies in high-risk multiple myeloma: navigating a gray area.
Impact
Anderson et al., Boston, United States. In J Clin Oncol, 2014
Bone marrow biopsy showed 60% infiltration with lambda light chain-restricted plasma cells staining positive for CD138 and CD56 and negative for CD45 by flow cytometry (Fig 1).
IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases.
Impact
Fillatreau et al., Berlin, Germany. In Nature, 2014
During Salmonella infection, IL-35- and IL-10-producing B cells corresponded to two largely distinct sets of surface-IgM(+)CD138(hi)TACI(+)CXCR4(+)CD1d(int)Tim1(int) plasma cells expressing the transcription factor Blimp1 (also known as Prdm1).
Progression in smoldering myeloma is independently determined by the chromosomal abnormalities del(17p), t(4;14), gain 1q, hyperdiploidy, and tumor load.
Impact
Hose et al., Heidelberg, Germany. In J Clin Oncol, 2014
were assessed in CD138-purified myeloma cells by interphase fluorescent in situ hybridization (iFISH) alongside clinical parameters in a consecutive series of 248 patients with SMM.
Syndecan 1 plays a novel role in enteral glutamine's gut-protective effects of the postischemic gut.
GeneRIF
Kozar et al., Houston, United States. In Shock, 2012
These results suggest that syndecan 1 plays a novel role in the protective effects of enteral glutamine in the postischemic gut.
Melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression.
GeneRIF
Oh et al., Seoul, South Korea. In J Biol Chem, 2012
MC1R regulates melanoma cell migration via inhibition of syndecan-2 expression.
Extensions of PSD-95/discs large/ZO-1 (PDZ) domains influence lipid binding and membrane targeting of syntenin-1.
GeneRIF
Ivarsson et al., Leuven, Belgium. In Febs Lett, 2012
study adds new components to the multi-dentate membrane targeting mechanism and highlights the role of N- and C-terminal PDZ extensions of PSD-95/ZO-1 in the regulation of syntenin-1 plasma membrane localization
[Construction and identification of mouse wildtype-syndecan-1 and unshedding-syndecan-1 expressing vector].
GeneRIF
Chen et al., Guangzhou, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
Data show that wildtype-syndecan-1(WT-sdc1) and unshedding-syndecan-1(uS-sdc1) are successfully constructed.
Prognostic value of hepatocyte growth factor, syndecan-1, and osteopontin in multiple myeloma and monoclonal gammopathy of undetermined significance.
GeneRIF
Scudla et al., Olomouc, Czech Republic. In Scientificworldjournal, 2011
We conclude that serum levels of HGF, OPN, and SYN correspond to the activity of MM and might become useful in differentiation of MGUS, asymptomatic MM, and overt/symptomatic form of MM.
More papers using syndecan-1 antibodies
Growth factor–induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells
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Lander Arthur D. et al., In The Journal of Cell Biology, 1994
... ); mouse anti–human syndecan-1 mAb (B-B4) was purchased from Serotec; anti–β-tubulin (D-10) was obtained from Santa Cruz Biotechnology, Inc.; and monoclonal anti-myc ...
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