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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Synaptotagmin VI

synaptotagmin VI, synaptotagmin 6, SYT6
The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: Rab3A, NSF, CAN, C2A, ACID
Papers on synaptotagmin VI
Identification of inherited genetic variations influencing prognosis in early-onset breast cancer.
Eccles et al., Southampton, United Kingdom. In Cancer Res, 2013
Four further associations at or close to the PBX1, RORα, NTN1, and SYT6 loci also came close to genome-wide significance levels (P = 10(-6)).
Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients.
Gebicke-Haerter et al., Göttingen, Germany. In Eur Arch Psychiatry Clin Neurosci, 2012
Their gene products belonged to vesicle-associated proteins, that is, synaptotagmin 6 and syntaxin 12, to cytoskeletal proteins, like myosin 6, pleckstrin, or to proteins of the extracellular matrix, such as collagens, or laminin C3.
Methyl-CpG binding column-based identification of nine genes hypermethylated in colorectal cancer.
Siedlecki et al., Warsaw, Poland. In Mol Carcinog, 2011
The frequency of their promoter methylation was assessed in the larger group of patients (n = 77): KCNK12 (methylated in 41% of CRC patients), GPR101 (40%), CDH2 (45%), BARX1 (56%), CNTFR (22%), SYT6 (64%), SMO (21%), EPHA5 (43%), and GSPT2 (21%).
Calcineurin-mediated dephosphorylation of synaptotagmin VI is necessary for acrosomal exocytosis.
GeneRIF
Mayorga et al., Mendoza, Argentina. In J Biol Chem, 2010
synaptotagmin must be dephosphorylated at a specific window of time and phosphorylated synaptotagmin has an active role at early stages of the acrosomal exocytosis.
Molecular analysis of neocortical layer structure in the ferret.
Ragsdale et al., Chicago, United States. In J Comp Neurol, 2010
Our major findings are: 1) Many but not all layer markers tested show similar patterns of layer-specific gene expression between mouse and ferret cortex, supporting the view that layer-specific cell type identity is conserved at a molecular level across mammalian superorders; 2) Our panel of deep layer markers (ER81/ETV1, SULF2, PCP4, FEZF2/ZNF312, CACNA1H, KCNN2/SK2, SYT6, FOXP2, CTGF) provides molecular evidence that the specific stratifications of layers 5 and 6 into 5a, 5b, 6a, and 6b are also conserved between rodents and carnivores; 3) Variations in layer-specific gene expression are more pronounced across areas of ferret cortex than between homologous areas of mouse and ferret cortex; 4) This variation of area gene expression was clearest with the superficial layer markers studied (SERPINE2, MDGA1, CUX1, UNC5D, RORB/NR1F2, EAG2/KCNH5).
PTP1B dephosphorylates N-ethylmaleimide-sensitive factor and elicits SNARE complex disassembly during human sperm exocytosis.
Tomes et al., Mendoza, Argentina. In J Biol Chem, 2009
The acrosome reaction, a specialized type of regulated exocytosis undergone by sperm, is initiated by calcium and carried out by a number of players, including tyrosine kinases and phosphatases, and fusion-related proteins such as Rab3A, alpha-SNAP, N-ethylmaleimide-sensitive factor (NSF), SNAREs, complexin, and synaptotagmin VI.
Identification of novel epigenetic markers for clear cell renal cell carcinoma.
GeneRIF
Liou et al., Boston, United States. In J Urol, 2008
SYT6 is hypermethylated in renal cell carcinoma.
Complexin/synaptotagmin interplay controls acrosomal exocytosis.
Mayorga et al., Mendoza, Argentina. In J Biol Chem, 2007
In this report, we show that the C2B domain of synaptotagmin VI and an anti-complexin antibody blocked the formation of trans SNARE complexes in permeabilized human sperm, and that this effect was reversed by adding complexin.
Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis.
GeneRIF
Mayorga et al., Mendoza, Argentina. In Dev Biol, 2005
Acrosomal exocytosis is regulated through the PKC-mediated phosphorylation of conserved threonines in the polybasic regions of synaptotagmin VI.
Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction.
Ngsee et al., Ottawa, Canada. In J Biol Chem, 2005
Sperm express Syt VI and VIII and Stx2, which are co-localized to the acrosomal compartment where they might mediate exocytosis in response to calcium influx.
alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction.
Mayorga et al., Mendoza, Argentina. In Mol Hum Reprod, 2005
Aided by a streptolysin-O permeabilization protocol developed in our laboratory, we have previously demonstrated requirements for Rab3A, N-ethylmaleimide-sensitive factor (NSF), several soluble NSF-attachment protein receptor (SNARE) proteins, and synaptotagmin VI in the human sperm AR.
SNARE complex assembly is required for human sperm acrosome reaction.
Mayorga et al., Mendoza, Argentina. In Dev Biol, 2002
Aided by a streptolysin-O permeabilization protocol developed in our laboratory, we have previously demonstrated requirements for Rab3A, NSF, and synaptotagmin VI in the human sperm acrosome reaction.
Synaptotagmin VI participates in the acrosome reaction of human spermatozoa.
Mayorga et al., Mendoza, Argentina. In Dev Biol, 2001
The ubiquitous synaptotagmin VI isoform was found in human sperm cells by Western blot analysis.
Alternative splicing of synaptotagmins involving transmembrane exon skipping.
Goedert et al., Cambridge, United Kingdom. In Febs Lett, 1999
Although the expression of most synaptotagmins predominates in neural tissue, we find that by contrast, synaptotagmin 6 is more abundant in thymus.
Role of synaptotagmin, a Ca2+ and inositol polyphosphate binding protein, in neurotransmitter release and neurite outgrowth.
Review
Mizutani et al., Tokyo, Japan. In Chem Phys Lipids, 1999
They are classified from their distribution as neuronal (synaptotagmin I-V, X, and XI) and the ubiquitous type (synaptotagmin VI-IX).
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