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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Synaptotagmin IV

synaptotagmin IV, Syt4
Top mentioned proteins: SYT-SSX, CAN, ACID, V1a, C2A
Papers on synaptotagmin IV
Ketamine Inhibits ATP-Evoked Exocytotic Release of Brain-Derived Neurotrophic Factor from Vesicles in Cultured Rat Astrocytes.
Zorec et al., Ljubljana, Slovenia. In Mol Neurobiol, Jan 2016
As revealed by double-fluorescent micrographs, BDNF-pHse localized to vesicles positive for the soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) proteins, vesicle-associated membrane protein 2 (VAMP2), VAMP3, and synaptotagmin IV.
Up-regulation of Synaptotagmin IV within amyloid plaque-associated dystrophic neurons in Tg2576 mouse model of Alzheimer's disease.
Glavan et al., Ljubljana, Slovenia. In Croat Med J, 2013
AIM: To investigate the involvement of the vesicular membrane trafficking regulator Synaptotagmin IV (Syt IV) in Alzheimer's disease pathogenesis and to define the cell types containing increased levels of Syt IV in the β-amyloid plaque vicinity.
Regulation of postsynaptic retrograde signaling by presynaptic exosome release.
Budnik et al., Worcester, United States. In Neuron, 2013
Here we show that a retrograde signal mediated by Synaptotagmin 4 (Syt4) is transmitted to the postsynaptic cell through anterograde delivery of Syt4 via exosomes.
Cell therapy modulates expression of Tax1-binding protein 1 and synaptotagmin IV in a model of optic nerve lesion.
Santiago et al., Rio de Janeiro, Brazil. In Invest Ophthalmol Vis Sci, 2012
RESULTS: Among the differentially displayed genes, transcription of the antiapoptotic Tax1-binding protein 1 (Tax1BP1) and Synaptotagmin IV (Syt IV), an immediate early gene, is increased in the treated group.
Exocytosis in the frog amphibian papilla.
Narins et al., Los Angeles, United States. In J Assoc Res Otolaryngol, 2012
While all AP hair cells express both otoferlin and synaptotagmin IV (SytIV), we obtained evidence of a tonotopic distribution of the calcium buffer calretinin which may further increase temporal resolution at the level of the hair cell synapse.
Temporal characteristics of vesicular fusion in astrocytes: examination of synaptobrevin 2-laden vesicles at single vesicle resolution.
Parpura et al., Birmingham, United States. In J Physiol, 2011
Expression of exogenous synaptotagmin 1 (Syt1) in astrocytes endogenously expressing Syt4, led to a greater proportion of transient fusions when astrocytes were stimulated with bradykinin, a stimulus otherwise resulting in more full fusions.
Synaptotagmin IV acts as a multi-functional regulator of Ca2+-dependent exocytosis.
Fukuda et al., Sendai, Japan. In Neurochem Res, 2011
In response to stimuli, secretary cells secrete a variety of signaling molecules packed in vesicles (e.g., neurotransmitters and peptide hormones) into the extracellular space by exocytosis.
Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance.
Cai et al., United States. In Neuron, 2011
Synaptotagmin 4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased synaptotagmin 4 binding to vesicles.
Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice.
Deussing et al., München, Germany. In Plos One, 2010
Additionally, we confirmed brain region-specific differences in the expression of synaptotagmin 4 (Syt4).Our identification of about 90 polymorphisms in Ctsb suggested that this gene might play a critical role in shaping our mouse model's behavioral endophenotypes.
Brain regions and genes affecting postural control.
Strazielle et al., Rouen, France. In Prog Neurobiol, 2007
With the gene deletion technique in mice, specific genes expressed in cerebellum encoding glutamate receptors (Grid2 and Grm1) and other molecules (Prkcc, Cntn6, Klf9, Syt4, and En2) have also been shown to affect postural control.
Multiple molecular and neuropharmacological effects of MDMA (Ecstasy).
Simantov, Israel. In Life Sci, 2004
The effect of MDMA on two of these genes, GABA transporter 1 and synaptotagmin IV was studied in detail.
Insulin secretion by 'kiss-and-run' exocytosis in clonal pancreatic islet beta-cells.
Rutter et al., Bristol, United Kingdom. In Biochem Soc Trans, 2003
However, both the frequency and the kinetics of NPY.Venus release were modulated by stimulus strength or by overexpression of synaptotagmin IV, demonstrating the plasticity of 'kiss-and-run' fusion.
Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain.
Schwarz et al., Cambridge, United Kingdom. In Nature, 2002
Synaptotagmin IV, a related isoform that does not bind Ca(2+) in the C(2)A domain, might be an inhibitor of release.
Biosynthesis and secretion of pituitary hormones: dynamics and regulation.
Machen et al., Berkeley, United States. In Arch Physiol Biochem, 2002
Two SNAREs, VAMP4 and synaptotagmin IV, enter newly formed granules but are removed from the maturing granule membrane by vesicle budding.
Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles.
Jackson et al., Madison, United States. In Science, 2001
Overexpression of synaptotagmin I prolonged the time from fusion pore opening to dilation, whereas synaptotagmin IV shortened this time.
Synaptic function modulated by changes in the ratio of synaptotagmin I and IV.
Chapman et al., Madison, United States. In Nature, 1999
Chronic depolarization or seizure activity results in the upregulation of a distinct and unusual isoform of the synaptotagmin family, synaptotagmin IV.
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